Rv0191

major facilitator superfamily

Validation StatusCandidate

Overview

Validation Method: differential gene expression analysis
Drug Classes: Fluoroquinolone, Rifampin, Pyrazinamide
Organisms: Mycobacterium tuberculosis
Geographic Location: China
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V179A	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	Card Database	Established
A213T	-	single resistance variant	Mycobacterium tuberculosis	Pyrazinamide	Card Database	Established

Papers3

Mycobacterium tuberculosis Gene Expression Associated With Fluoroquinolone Resistance and Efflux Pump Inhibition.

PMID 37079382 · 2023

The study identified Rv0191 as a gene with increased expression associated with fluoroquinolone resistance in Mycobacterium tuberculosis, suggesting its potential role in efflux-mediated resistance.

Gene Information

Gene Name: Rv0191
Allele: Rv0191
Encodes: major facilitator superfamily
Source Database: Reslit
Confers Resistance To: Fluoroquinolone
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: differential gene expression analysis

Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis.

PMID 40887591 · 2025

Rv0677c and Rv0191 efflux pump genes were identified as the primary contributors to rifampin resistance in rpoB mutant Mycobacterium tuberculosis strains, with their overexpression significantly affecting MIC values and resistance levels.

Gene Information

Gene Name: Rv0191
Allele: Rv0191
Encodes: efflux pump
Source Database: Reslit
Confers Resistance To: Rifampin
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: China
Validation Method: qPCR and MIC measurement
Sequence Accession: PRJNA1146932

Browse AMR Genes

Rv0191

Mutations

Gene Information

Gene Information