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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
probable conserved integral membrane transport (efflux) protein
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| V219A | - | - | Mycobacterium tuberculosis | Pyrazinamide|Isoniazid|Streptomycin | Reslit | Candidate |
Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux.
Rifampicin-resistant Mycobacterium tuberculosis strains exhibit reduced susceptibility to ofloxacin through the activation of efflux pumps. Specific efflux-related genes such as Rv3239c, Rv1258c, Rv2333c, Rv1877, Rv2994, Rv1634, Rv1747, whiB7, and Rv1002c were upregulated upon rifampicin exposure, contributing to ofloxacin resistance.
Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates.
The study identified overexpression of Rv3065, Rv1410c, Rv1258c, Rv2459, and Rv2942 efflux pump genes in multidrug-resistant Mycobacterium tuberculosis isolates, contributing to resistance against isoniazid and rifampin. Additionally, mutations in rpoB, katG, and inhA genes were found to be associated with drug resistance.
Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis.
Rv0677c and Rv0191 efflux pump genes were identified as the primary contributors to rifampin resistance in rpoB mutant Mycobacterium tuberculosis strains, with their overexpression significantly affecting MIC values and resistance levels.
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