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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
MFS transporter
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| rv1410c | Reslit | 1 | Rifampicin | Mycobacterium tuberculosis | - | 2012 | - | - |
| Rv1410c | Reslit | 2 | Isoniazid, Rifampin |
| Iran, China |
| 2021, 2025 |
| MW916092|MW916093|MW913094|MH734237 |
| - |
The role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance.
The paper discusses the role of transport mechanisms, particularly efflux pumps, in Mycobacterium tuberculosis drug resistance and tolerance, highlighting the importance of efflux pump activity in reducing drug susceptibility.
Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates.
The study identified overexpression of Rv3065, Rv1410c, Rv1258c, Rv2459, and Rv2942 efflux pump genes in multidrug-resistant Mycobacterium tuberculosis isolates, contributing to resistance against isoniazid and rifampin. Additionally, mutations in rpoB, katG, and inhA genes were found to be associated with drug resistance.
Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis.
Rv0677c and Rv0191 efflux pump genes were identified as the primary contributors to rifampin resistance in rpoB mutant Mycobacterium tuberculosis strains, with their overexpression significantly affecting MIC values and resistance levels.
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