Rv1453

transcription factor

Validation StatusCandidate

Overview

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	C-17T	-	Mycobacterium tuberculosis	Clofazimine	Reslit	Candidate

Papers1

Rv1453 is associated with clofazimine resistance in Mycobacterium tuberculosis.

The study identifies a mutation in the intergenic region of the Rv1453 gene associated with clofazimine resistance in Mycobacterium tuberculosis.

Gene Name: Rv1453
Allele: Rv1453
Encodes: transcription factor
Source Database: Reslit
Mechanism: regulates the expression of the qor gene
Confers Resistance To: Clofazimine
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: China
Validation Method: Rv1453 knockout resulted in increased MIC of CFZ
Sequence Accession: SRR22873596|SRR22873595|SRR22873594|SRR22873609|SRR22873608|SRR22873607|SRR22873606|SRR22873605|SRR22873604|SRR22873603|SRR22873602