Rv1634

possible drug efflux membrane protein

Validation StatusCandidate

Overview

Mechanism: efflux
Validation Method: RT-qPCR and MIC testing
Drug Classes: Ofloxacin, Fluoroquinolone
Organisms: Mycobacterium tuberculosis
Geographic Location: Russia
Papers: 2
Databases: Reslit

Papers2

Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux.

PMID 21512166 · 2011

Rifampicin-resistant Mycobacterium tuberculosis strains exhibit reduced susceptibility to ofloxacin through the activation of efflux pumps. Specific efflux-related genes such as Rv3239c, Rv1258c, Rv2333c, Rv1877, Rv2994, Rv1634, Rv1747, whiB7, and Rv1002c were upregulated upon rifampicin exposure, contributing to ofloxacin resistance.

Gene Information

Gene Name: Rv1634
Allele: Rv1634
Encodes: possible drug efflux membrane protein
Source Database: Reslit
Mechanism: efflux
Confers Resistance To: Ofloxacin
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: RT-qPCR and MIC testing

Comparative genomic analysis of Mycobacterium tuberculosis drug resistant strains from Russia.

PMID 23437175 · 2013

The study identified several genetic mutations associated with drug resistance in Mycobacterium tuberculosis strains from Russia, including mutations in rpoB, katG, embB, pncA, rrs, rpsL, ethA, ndhA, Rv0194, Rv1634, and Rv2688c, which confer resistance to rifampicin, isoniazid, ethambutol, pyrazinamide, kanamycin, amikacin, streptomycin, ethionamide, and fluoroquinolone.

Gene Information

Gene Name: Rv1634
Allele: Rv1634
Encodes: drug efflux membrane protein
Source Database: Reslit
Confers Resistance To: Fluoroquinolone
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Russia
Validation Method: SNP analysis
Sequence Accession: CP002992|SRA051492|AIIE01000000

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Rv1634

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