Rv1877

probable conserved integral membrane protein

Validation StatusConfirmed2+ DBs

Overview

Mechanism: efflux
Validation Method: RT-qPCR and MIC testing
Drug Classes: Para-aminosalicylic acid
Organisms: Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Geographic Location: Belarus|South Africa|South Korea|India
Papers: 2
Databases: Card DatabaseReslit

Papers2

Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux.

PMID 21512166 · 2011

Rifampicin-resistant Mycobacterium tuberculosis strains exhibit reduced susceptibility to ofloxacin through the activation of efflux pumps. Specific efflux-related genes such as Rv3239c, Rv1258c, Rv2333c, Rv1877, Rv2994, Rv1634, Rv1747, whiB7, and Rv1002c were upregulated upon rifampicin exposure, contributing to ofloxacin resistance.

Gene Information

Gene Name: Rv1877
Allele: Rv1877
Encodes: probable conserved integral membrane protein
Source Database: Reslit
Mechanism: efflux
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: RT-qPCR and MIC testing

Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.

PMID 30333483 · 2018

The study identifies 33 known AMR genes and 24 new genetic signatures of AMR in Mycobacterium tuberculosis using machine learning and structural analysis. It also reveals 97 epistatic interactions across 10 resistance classes and provides mechanistic insights into the selection of these genes.

Gene Information

Gene Name: Rv1877
Allele: Rv1877
Encodes: hypothetical protein
Source Database: Reslit
Mechanism: mutation in the gene leads to resistance to para-aminosalicylic acid
Confers Resistance To: Para-aminosalicylic acid
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Belarus|South Africa|South Korea|India
Validation Method: machine learning and structural analysis

PMID N/A

Gene Information

Gene Name: Rv1877
Allele: Rv1877
Encodes: major facilitator superfamily (MFS) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • Mycobacterium tuberculosis H37Rv
Sequence Accession: NC_000962.3
Protein Accession: NP_216393.1
Notes: ARO:3007662

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Rv1877

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