Rv2459

efflux pump

Validation StatusCandidate

Overview

Validation Method: quantitative real-time PCR
Drug Classes: Isoniazid, Rifampin
Organisms: Mycobacterium tuberculosis
Geographic Location: China, Iran
Papers: 2
Databases: Reslit

Papers2

Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates.

PMID 34337183 · 2021

The study identified overexpression of Rv3065, Rv1410c, Rv1258c, Rv2459, and Rv2942 efflux pump genes in multidrug-resistant Mycobacterium tuberculosis isolates, contributing to resistance against isoniazid and rifampin. Additionally, mutations in rpoB, katG, and inhA genes were found to be associated with drug resistance.

Gene Information

Gene Name: Rv2459
Allele: Rv2459
Encodes: efflux pump
Source Database: Reslit
Confers Resistance To: IsoniazidRifampin
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Iran
Validation Method: quantitative real-time PCR
Sequence Accession: MW916092|MW916093|MW913094|MH734237

Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis.

PMID 40887591 · 2025

Rv0677c and Rv0191 efflux pump genes were identified as the primary contributors to rifampin resistance in rpoB mutant Mycobacterium tuberculosis strains, with their overexpression significantly affecting MIC values and resistance levels.

Gene Information

Gene Name: Rv2459
Allele: Rv2459
Encodes: efflux pump
Source Database: Reslit
Confers Resistance To: Rifampin
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: China
Validation Method: qPCR analysis of efflux pump gene expression
Sequence Accession: PRJNA1146932

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Rv2459

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