Rv2477c

macrolide-transport ATP-binding protein

Validation StatusCandidate

Overview

Validation Method: protein abundance and ATP-binding analysis
Drug Classes: Fluoroquinolone, Kanamycin, Amikacin, Kanamycin|Amikacin
Organisms: Mycobacterium tuberculosis
Papers: 3
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
W135G	-	-	-	Kanamycin\|Amikacin	Reslit	Candidate

Papers3

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis.

PMID 23462205 · 2013

The study identifies 122 ATP-binding proteins in Mycobacterium tuberculosis under normoxic and hypoxic conditions, highlighting proteins involved in energy metabolism and lipid biosynthesis that may serve as therapeutic targets.

Gene Information

Gene Name: Rv2477c
Allele: Rv2477c
Encodes: macrolide-transport ATP-binding protein
Source Database: Reslit
Confers Resistance To: Fluoroquinolone
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: protein abundance and ATP-binding analysis
Sequence Accession: PXD000141

The ATP-Binding Cassette (ABC) Transport Systems in Mycobacterium tuberculosis: Structure, Function, and Possible Targets for Therapeutics.

PMID 33291531 · 2020

This review discusses the structure, function, and potential therapeutic targeting of ABC transporters in Mycobacterium tuberculosis, emphasizing their roles in nutrient import, drug efflux, and virulence.

Gene Information

Gene Name: Rv2477c
Allele: Rv2477c
Encodes: efflux pump
Source Database: Reslit
Confers Resistance To: KanamycinAmikacin
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: gene expression analysis

Browse AMR Genes

Rv2477c

Mutations

Gene Information

Gene Information