Rv2994

probable conserved integral membrane protein

Validation StatusCandidate

Overview

Mechanism: efflux
Validation Method: RT-qPCR and MIC testing
Drug Classes: Ofloxacin
Organisms: Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux.

PMID 21512166 · 2011

Rifampicin-resistant Mycobacterium tuberculosis strains exhibit reduced susceptibility to ofloxacin through the activation of efflux pumps. Specific efflux-related genes such as Rv3239c, Rv1258c, Rv2333c, Rv1877, Rv2994, Rv1634, Rv1747, whiB7, and Rv1002c were upregulated upon rifampicin exposure, contributing to ofloxacin resistance.

Gene Information

Gene Name: Rv2994
Allele: Rv2994
Encodes: probable conserved integral membrane protein
Source Database: Reslit
Mechanism: efflux
Confers Resistance To: Ofloxacin
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: RT-qPCR and MIC testing

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Rv2994

Gene Information