TolC
outer membrane factor
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to TolC
AMR Rules
Browse AMR rules for TolC
Validation StatusCandidate
Overview
- Validation Method
- agar dilution MIC test
- Drug Classes
- ampicillin, chloramphenicol, florfenicol, cloxacillin, puromycin, erythromycin, methotrexate, novobiocin, ciprofloxacin, norfloxacin, nalidixic acid, rifampin, fusidic acid, streptomycin, sulfacetamide, tetracycline, deoxycholate, sodium cholate, sodium taurodeoxycholate, sodium oxalate, proflavin, crystal violet, acriflavin, ethidium bromide, tetraphenylphosphonium, rhodamine 6g, tetraphenylarsonium chloride, dequalinium chloride, benzalkonium chloride, daunomycin, plumbagin, methyl viologen
- Organisms
- Escherichia coli W3110
- Papers
- 1
- Databases
- Reslit
Papers1
1
Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.
The study identified that the deletion of tolC and acrAB significantly increased susceptibility to various antibiotics, antiseptics, detergents, and dyes in Escherichia coli. Additionally, mdfA and emrE were found to contribute to resistance against specific compounds.
Gene Information
- Gene Name
- TolC
- Allele
- TolC
- Encodes
- outer membrane factor
- Source Database
- Reslit
- Confers Resistance To
- ampicillinchloramphenicolflorfenicolcloxacillinpuromycinerythromycinmethotrexatenovobiocinciprofloxacinnorfloxacinnalidixic acidrifampinfusidic acidstreptomycinsulfacetamidetetracyclinedeoxycholatesodium cholatesodium taurodeoxycholatesodium oxalateproflavincrystal violetacriflavinethidium bromidetetraphenylphosphoniumrhodamine 6gtetraphenylarsonium chloridedequalinium chloridebenzalkonium chloridedaunomycinplumbaginmethyl viologen
- Organisms Tested In
- • Escherichia coli W3110
- Validation Method
- agar dilution MIC test
Comments (0)
No comments yet. Be the first to comment!