Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R322M | - | decreased use of D-serine, broadened specificity for utilization of other D-amino acids | Enterococcus casseliflavus, Escherichia coli | Vancomycin | Reslit | Candidate |
| F250Y | - | decreased use of D-serine, broadened specificity for utilization of other D-amino acids | Escherichia coli, Enterococcus casseliflavus | Vancomycin | Reslit | Candidate |
| L282R | - | switch towards D-alanyl-D-serine formation | Enterococcus casseliflavus, Escherichia coli |
Vancomycin |
Reslit |
| Candidate |
Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases.
Mutations in VanC2 alter the specificity of the ligase, affecting vancomycin resistance.
© 2026 ResLit. Data sourced from PubMed literature analysis.
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