aac(3)-I
AAC(3)-I family aminoglycoside 3-N-acetyltransferase
Overview
- Validation Method
- cloning and functional analysis
- Drug Classes
- GENTAMICIN, gentamicin
- Organisms
- Pseudomonas aeruginosa, Escherichia coli, Salmonella enterica serovar Typhimurium, uncultured bacterium
- Geographic Location
- Japan
- Alleles
- 2
- Papers
- 3
- Databases
- Reference Gene CatalogReslit
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| aac(3)-I | Reference Gene CatalogReslit | 7 | GENTAMICIN, gentamicin | Pseudomonas aeruginosa +2 | - | 2005, 2011 | AJ877225.1 | CAI46944.1 |
| aac3 | Reslit | 1 | gentamicin | Salmonella enterica serovar Typhimurium | Japan | 2005 | AY224185|AF550415|AF326777 | - |
The IncP-6 plasmid Rms149 consists of a small mobilizable backbone with multiple large insertions.
Gene Information
- Gene Name
- aac(3)-I
- Allele
- aac(3)-I
- Encodes
- AAC(3)-I family aminoglycoside 3-N-acetyltransferase
- Source Database
- Reference Gene Catalog
- Confers Resistance To
- GENTAMICIN
- Organisms Tested In
- • Pseudomonas aeruginosa
- Sequence Accession
- AJ877225.1
- Protein Accession
- CAI46944.1
The IncP-6 plasmid Rms149 consists of a small mobilizable backbone with multiple large insertions.
Gene Information
- Gene Name
- aac(3)-I
- Allele
- aac(3)-I
- Encodes
- AAC(3)-I family aminoglycoside 3-N-acetyltransferase
- Source Database
- Reference Gene Catalog
- Confers Resistance To
- GENTAMICIN
- Organisms Tested In
- • Pseudomonas aeruginosa
- Sequence Accession
- AJ877225.1
- Protein Accession
- CAI46944.1
The IncP-6 plasmid Rms149 consists of a small mobilizable backbone with multiple large insertions.
The study characterizes the IncP-6 plasmid Rms149, identifying several AMR genes including aac(3)-I, aadA5, intI1, qacEΔ1, and sul1, which confer resistance to gentamicin, streptomycin, spectinomycin, quaternary ammonium compounds, and sulfonamide, respectively.
Gene Information
- Gene Name
- aac(3)-I
- Allele
- aac(3)-I
- Encodes
- aminoglycoside acetyltransferase
- Source Database
- Reslit
- Confers Resistance To
- gentamicin
- Organisms Tested In
- • Pseudomonas aeruginosa• Escherichia coli
- Validation Method
- cloning and functional analysis
- Sequence Accession
- AJ877225
Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.
The study identifies high-level fluoroquinolone-resistant Salmonella enterica serovar Typhimurium isolates with mutations in gyrA (S83F, D87N/G) and parC (S80R), along with resistance genes blaOXA-30, aadA1, dhfr12, aadA2, aac3, catA, and tetRA.
Gene Information
- Gene Name
- aac(3)-I
- Allele
- aac3
- Encodes
- aminoglycoside acetyltransferase
- Source Database
- Reslit
- Confers Resistance To
- gentamicin
- Organisms Tested In
- • Salmonella enterica serovar Typhimurium
- Geographic Location
- Japan
- Validation Method
- PCR and sequencing
- Sequence Accession
- AY224185|AF550415|AF326777
Characterization of novel antibiotic resistance genes identified by functional metagenomics on soil samples.
Gene Information
- Gene Name
- aac(3)-I
- Allele
- aac(3)-I
- Encodes
- AAC(3)-I family aminoglycoside 3-N-acetyltransferase
- Source Database
- Reference Gene Catalog
- Confers Resistance To
- GENTAMICIN
- Organisms Tested In
- • uncultured bacterium
- Sequence Accession
- FN640465.1
- Protein Accession
- CBI71176.1
Characterization of novel antibiotic resistance genes identified by functional metagenomics on soil samples.
Gene Information
- Gene Name
- aac(3)-I
- Allele
- aac(3)-I
- Encodes
- AAC(3)-I family aminoglycoside 3-N-acetyltransferase
- Source Database
- Reference Gene Catalog
- Confers Resistance To
- GENTAMICIN
- Organisms Tested In
- • uncultured bacterium
- Sequence Accession
- FN640465.1
- Protein Accession
- CBI71176.1
Gene Information
- Gene Name
- aac(3)-I
- Allele
- aac(3)-I
- Encodes
- AAC(3)-I family aminoglycoside 3-N-acetyltransferase
- Source Database
- Reference Gene Catalog
- Confers Resistance To
- GENTAMICIN
- Organisms Tested In
- • Pseudomonas aeruginosa
- Sequence Accession
- AF318077.1
- Protein Accession
- AAK12088.1
Gene Information
- Gene Name
- aac(3)-I
- Allele
- aac(3)-I
- Encodes
- AAC(3)-I family aminoglycoside 3-N-acetyltransferase
- Source Database
- Reference Gene Catalog
- Confers Resistance To
- GENTAMICIN
- Organisms Tested In
- • Pseudomonas aeruginosa
- Sequence Accession
- AF318077.1
- Protein Accession
- AAK12088.1
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