Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside N-acetyltransferase AAC(3)-IIIa
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| aac(3)-IIIa | ResFinder Database | 1 | SISOMICIN, DIBEKACIN +2 | Pseudomonas aeruginosa | - | 1991 | X55652 | - |
| AAC(3)-IIIa | Card Database |
| 6 |
| SISOMICIN, DIBEKACIN +5 |
| Pseudomonas aeruginosa +3 |
| - |
| 1991, 2010, 2022, 2025 |
| X55652.1 |
| CAA39184.1 |
| aac(3)-III | Reslit | 3 | Gentamicin, Tobramycin +3 | Klebsiella pneumoniae +2 | Kenya, Portugal | 2017, 2023 | NCBI Accession no. KX377894|KX377894 | - |
| aac(3)IIIa | Reslit | 1 | Aminoglycoside | Pseudomonas aeruginosa | China | 2023 | - | - |
Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli.
Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli.
Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli.
Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli.
Aminoglycoside modifying enzymes.
The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and β-lactam resistance genes in the gut microbiota.
The study identified numerous aminoglycoside and β-lactam resistance gene homologues in the gut microbiota of healthy adults, indicating that the human gut microbiota serves as a reservoir for antibiotic resistance genes even in the absence of recent antibiotic exposure.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Resistance genomics and molecular epidemiology of high-risk clones of ESBL-producing Pseudomonas aeruginosa in young children.
The study identifies multiple AMR genes in ESBL-producing P. aeruginosa isolates from pediatric patients, including blaCTX-M-15, blaSHV-11, blaNDM-1, blaNDM-5, aac(3)IIIa, and tet(A). These genes contribute to resistance against cephalosporins, carbapenems, aminoglycosides, and glycylcyclines.
Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens.
The study identifies numerous novel aminoglycoside resistance genes (AMEs) in human pathogens through extensive computational screening of bacterial genomes. Twenty-four out of twenty-eight experimentally tested AMEs conferred resistance to aminoglycosides in E. coli, with seventeen exceeding clinical breakpoints.
Determination of Antimicrobial Resistance and the Impact of Imipenem + Cilastatin Synergy with Tetracycline in Pseudomonas aeruginosa Isolates from Sepsis.
The study identified several AMR genes in P. aeruginosa isolates, including aac(3)-II, aac(3)-III, blaOXA-48, blaSPM, blaIMP, blaNDM, blaPER, blaVIM, and oprD, which confer resistance to various antibiotics. These genes were detected using PCR and are associated with resistance mechanisms such as enzymatic modification and reduced antibiotic uptake.
Enzyme-mediated aminoglycoside resistance without target mimicry.
The study identifies AAC(3)-Ia and AAC(3)-XIa as aminoglycoside-modifying enzymes that do not use target mimicry, binding aminoglycosides in a non-canonical boat conformation. These enzymes confer resistance to several aminoglycosides, including gentamicin, sisomicin, and others.
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