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aac(3)-IXa

aminoglycoside N-acetyltransferase AAC(3)-IXa

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to aac(3)-IXa

AMR Rules

Browse AMR rules for aac(3)-IXa

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic modification
Validation Method: genetic analysis
Drug Classes: AMINOGLYCOSIDE, AMIKACIN, DIBEKACIN, PAROMOMYCIN, NEOMYCIN, KANAMYCIN, ARBEKACIN, GENTAMICIN, Aminoglycoside, Kanamycin, Gentamicin, Netilmicin, Tobramycin
Organisms: Micromonospora chalcea, Enterobacteriaceae, Escherichia coli
Alleles: 3
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
AAC(3)-IXa	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	4	AMINOGLYCOSIDE, AMIKACIN +7	Micromonospora chalcea +1	-

Papers3

Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae.

PMID 2060791 · 1991

Gene Information

Gene Name: aac(3)-IXa
Allele: AAC(3)-IXa
Encodes: aminoglycoside N-acetyltransferase AAC(3)-IXa
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: AMINOGLYCOSIDEAMIKACINDIBEKACINPAROMOMYCINNEOMYCINKANAMYCINARBEKACINGENTAMICIN
Organisms Tested In: • Micromonospora chalcea
Sequence Accession: M55427.1
Protein Accession: AAA25334.1
Notes: ARO:3002543

Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae.

PMID 2060791 · 1991

Gene Information

Gene Name: aac(3)-IXa
Allele: AAC(3)-IXa
Encodes: aminoglycoside N-acetyltransferase AAC(3)-IXa
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: AMINOGLYCOSIDEAMIKACINDIBEKACINPAROMOMYCINNEOMYCINKANAMYCINARBEKACINGENTAMICIN
Organisms Tested In: • Micromonospora chalcea
Sequence Accession: M55427.1
Protein Accession: AAA25334.1
Notes: ARO:3002543

Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae.

PMID 2060791 · 1991

Gene Information

Gene Name: aac(3)-IXa
Allele: AAC(3)-IXa
Encodes: aminoglycoside N-acetyltransferase AAC(3)-IXa, AAC(3)
Source Database: Card Database
Mechanism: Enzymatic modification, antibiotic inactivation
Confers Resistance To: AMINOGLYCOSIDEAMIKACINDIBEKACINPAROMOMYCINNEOMYCINKANAMYCINARBEKACINGENTAMICIN
Organisms Tested In: • Micromonospora chalcea
Sequence Accession: M55427.1
Protein Accession: AAA25334.1
Notes: ARO:3002543

Characterisation of aminoglycoside acetyltransferase-encoding genes of neomycin-producing Micromonospora chalcea and Streptomyces fradiae.

PMID 2060791 · 1991

Gene Information

Gene Name: aac(3)-IXa
Allele: aac(3)-IXa
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: AMIKACINPAROMOMYCINDIBEKACINNEOMYCINKANAMYCINARBEKACINGENTAMICIN
Organisms Tested In: • Micromonospora chalcea
Sequence Accession: M55427

Aminoglycoside modifying enzymes.

PMID 20833577 · 2010

The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.

Gene Information

Gene Name: aac(3)-IXa
Allele: AAC(3)-IXa
Encodes: N-acetyltransferase
Source Database: Reslit
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Enterobacteriaceae
Validation Method: genetic analysis

Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens.

PMID 37537271 · 2023

The study identifies numerous novel aminoglycoside resistance genes (AMEs) in human pathogens through extensive computational screening of bacterial genomes. Twenty-four out of twenty-eight experimentally tested AMEs conferred resistance to aminoglycosides in E. coli, with seventeen exceeding clinical breakpoints.

Gene Information

Gene Name: aac(3)-IXa
Allele: aac(3)-IX
Encodes: aminoglycoside acetyltransferase
Source Database: Reslit
Confers Resistance To: KanamycinGentamicinNetilmicinTobramycin
Organisms Tested In: • Escherichia coli
Validation Method: expression in E. coli and disk diffusion test