Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
bifunctional aminoglycoside N-acetyltransferase AAC(3)-Ib/aminoglycoside N-acetyltransferase AAC(6')-Ib''
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| aac(3)-Ib/aac(6')-Ib'' | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | TOBRAMYCIN, STREPTOMYCIN +4 | Pseudomonas aeruginosa +1 | China | 2002, 2025 | AF355189.1 | AAL82588.1 |
| AAC(3)-Ib | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | GENTAMICIN, aminoglycosides +5 | uncultured bacterium +5 | Italy, Europe, China | 1995, 2011, 2020, 2022, 2024, 2025 | CP002151.1 | ADU86600.1 |
| aac(3')-Ib-cr | Reslit | 1 | spectinomycin, streptomycin | Proteus mirabilis CC15031 | China | 2020 | CP031532|CP048787|PRJNA596082 | - |
Molecular characterization of a novel class 1 integron containing bla(GES-1) and a fused product of aac3-Ib/aac6'-Ib' gene cassettes in Pseudomonas aeruginosa.
Research Article
Molecular characterization of a novel class 1 integron containing bla(GES-1) and a fused product of aac3-Ib/aac6'-Ib' gene cassettes in Pseudomonas aeruginosa.
Research Article
Molecular characterization of a novel class 1 integron containing bla(GES-1) and a fused product of aac3-Ib/aac6'-Ib' gene cassettes in Pseudomonas aeruginosa.
Research Article
Sequencing and comparative analysis of IncP-1α antibiotic resistance plasmids reveal a highly conserved backbone and differences within accessory regions.
Research Article
First detection of autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 from a patient with bloodstream infection in Italy, October 2019.
Research Article
The study reports the first autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 strain in Italy, highlighting the presence of multiple beta-lactamase genes, aminoglycoside modifying enzymes, and multidrug efflux pumps contributing to its extensive drug resistance.
Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam.
Research Article
The study identifies multiple AMR genes in a KPC-3-producing K. pneumoniae isolate, including blaKPC-3, aac(3)-Ib, aac(6')-Ib-cr, aph(3')-Ia, blaOXA-1, blaSHV-214, mphA, qacH, catB3, arr-3, sul1, and dfrA14, which confer resistance to various antibiotics.
Biological Characteristics and Genetic Analysis of a Highly Pathogenic Proteus Mirabilis Strain Isolated From Dogs in China.
Research Article
The study identified 18 antibiotic resistance genes in the multidrug-resistant Proteus mirabilis strain CC15031, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and others.
River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics.
Research Article
The study identified various antibiotic resistance genes (ARGs) in river biofilms upstream and downstream of a wastewater treatment plant (WWTP), including qnrA, qnrS, mfsA, ermC, ermX, macB, mefA_10, cat, catB3, aadB, aph(3')-III, AAC(3)-Ib, bacA_1, blaPer-1, blaIMP, blaTEM, blaKPC, blaDHA, cblA, ermC, ermY, ermX, mdtL, cusF, copD, qacA, mecA, dfrF, arnA, sul1, sulA, vat(A), IS6100, ISS1N, Intl1, blaCTX-M, blaIMP, mefA_10, tolC, mdfF, acrA, dfrA27, aac(6')-IIa, vanA, intl3, and TTV. These genes were associated with resistance to various antibiotics such as fluoroquinolones, macrolides, chloramphenicol, aminoglycosides, beta-lactams, polymyxins, sulfonamides, and others. The study also found that the resistome composition varied between upstream and downstream sites, indicating the impact of WWTP effluents on the distribution of ARGs in river biofilms.
Characterization of a Salmonella enterica serovar Typhimurium lineage with rough colony morphology and multidrug resistance.
Research Article
The study identifies a multidrug-resistant Salmonella enterica serovar Typhimurium lineage with a rough colony morphology, carrying multiple AMR genes including aminoglycoside, beta-lactam, chloramphenicol, sulfonamide, tetracycline, and quinolone resistance genes. A specific mutation (-44G > T) in the csgD promoter was found to upregulate biofilm-related genes.
High-throughput clinical antimicrobial susceptibility testing and drug-resistant subpopulation detection in Gram-negative bacteria.
Research Article
The study introduces the EZMTT method for enhanced detection of drug-resistant subpopulations in Gram-negative bacteria, showing superior sensitivity compared to conventional methods like BMD and VITEK. It identifies specific resistance genes such as bla in clinical isolates.
A computational study exploring echinoderm-derived compounds for inhibition of aminoglycoside acetyltransferases.
Research Article
This study identified echinoderm-derived metabolites that show strong binding affinity and inhibitory potential against aminoglycoside acetyltransferases (AACs), including AAC(3)-Ib, AAC(6′)-Im, AAC(3)-Iva, and Aminoglycoside 2′-N-acetyltransferase. These compounds demonstrate promising activity in disrupting the function of these enzymes, which are critical for bacterial resistance to aminoglycoside antibiotics.
A computational study exploring echinoderm-derived compounds for inhibition of aminoglycoside acetyltransferases.
Research Article
This study identified echinoderm-derived metabolites that show strong binding affinity and inhibitory potential against aminoglycoside acetyltransferases (AACs), including AAC(3)-Ib, AAC(6′)-Im, AAC(3)-Iva, and Aminoglycoside 2′-N-acetyltransferase. These compounds demonstrate promising activity in disrupting the function of these enzymes, which are critical for bacterial resistance to aminoglycoside antibiotics.
Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa.
Research Article
The study identified and characterized the aac(3)-Ib gene, which encodes a 3-N-aminoglycoside acetyltransferase that confers resistance to gentamicin, astromicin, and sisomicin in Pseudomonas aeruginosa.
Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa.
Research Article
Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa.
Research Article
Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa.
Research Article
Cloning and characterization of a 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ib, from Pseudomonas aeruginosa.
Research Article
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