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aac(3)-Ic

aminoglycoside N-acetyltransferase AAC(3)-Ic

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to aac(3)-Ic

Browse AMR rules for aac(3)-Ic

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic modification
Validation Method: cloning in E. coli + susceptibility testing
Drug Classes: ASTROMICIN, FORTIMICIN, GENTAMICIN, Gentamicin, Sisomicin, Aminoglycoside
Organisms: Pseudomonas aeruginosa, Pseudomonas aeruginosa VA-182/00, Escherichia coli DH5alpha, Acinetobacter baumannii
Geographic Location: Iran, Italy, Saudi Arabia|Arctium fruticosum rhizosphere
Alleles: 2
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
AAC(3)-Ic	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	6	ASTROMICIN, FORTIMICIN +4	Pseudomonas aeruginosa +3

Papers3

1

Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron.

PMID 12709352 · 2003

Gene Information

Gene Name: aac(3)-Ic
Allele: AAC(3)-Ic
Encodes: aminoglycoside N-acetyltransferase AAC(3)-Ic
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: ASTROMICINFORTIMICINGENTAMICIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AJ511268.1
Protein Accession: CAD53575.1
Notes: ARO:3002531

2

Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron.

PMID 12709352 · 2003

Gene Information

Gene Name: aac(3)-Ic
Allele: AAC(3)-Ic
Encodes: aminoglycoside N-acetyltransferase AAC(3)-Ic, AAC(3)
Source Database: Card Database
Mechanism: Enzymatic modification, antibiotic inactivation
Confers Resistance To: ASTROMICINFORTIMICINGENTAMICIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AJ511268.1
Protein Accession: CAD53575.1
Notes: ARO:3002531

3

Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron.

PMID 12709352 · 2003

Gene Information

Gene Name: aac(3)-Ic
Allele: aac(3)-Ic
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: ASTROMICINFORTIMICINGENTAMICIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AJ511268

4

Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron.

PMID 12709352 · 2003

The study identifies a novel aac(3)-Ic gene from a Pseudomonas aeruginosa integron, which confers resistance to gentamicin and sisomicin.

Gene Information

Gene Name: aac(3)-Ic
Allele: AAC(3)-Ic
Encodes: 3-N-aminoglycoside acetyltransferase
Source Database: Reslit
Mechanism: acetylation of aminoglycosides
Confers Resistance To: GentamicinSisomicin
Organisms Tested In: • Pseudomonas aeruginosa VA-182/00
• Escherichia coli DH5alpha
Geographic Location: Italy
Validation Method: cloning in E. coli + susceptibility testing
Sequence Accession: AJ511268

5

Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron.

PMID 12709352 · 2003

Gene Information

Gene Name: aac(3)-Ic
Allele: AAC(3)-Ic
Encodes: aminoglycoside N-acetyltransferase AAC(3)-Ic
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: ASTROMICINFORTIMICINGENTAMICIN
Organisms Tested In: • Pseudomonas aeruginosa
Sequence Accession: AJ511268.1
Protein Accession: CAD53575.1
Notes: ARO:3002531

6

Molecular study of metallo-β-lactamases and integrons in Acinetobacter baumannii isolates from burn patients.

PMID 34372787 · 2021

High prevalence of MBLs genes, especially blaVIM, was identified in MDR A. baumannii isolates. Most of the strains carried class 1 integrons, and gene cassettes arrays including cmlA5 and cmlA7 were detected for the first time in A. baumannii strains in Iran.

Gene Information

Gene Name: aac(3)-Ic
Allele: AAC(3)-Ic
Encodes: aminoglycoside N-acetyltransferase
Source Database: Reslit
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Iran
Validation Method: PCR and sequencing

7

Functional analysis of bacterial genes accidentally packaged in rhizospheric phageome of the wild plant species Abutilon fruticosum.

PMID 37680975 · 2023

The study identified several antibiotic resistance genes (ARGs) accidentally packaged in the phageome of Abutilon fruticosum, including soxR, parY mutant, arr-1, iri, AAC(3)-Ic, and oleC, which confer resistance to various antibiotics such as tetracycline, rifampin, and gentamicin.

Gene Information

Gene Name: aac(3)-Ic
Allele: AAC(3)-Ic
Encodes: aminoglycoside acetyltransferase
Source Database: Reslit
Mechanism: antibiotic inactivation
Confers Resistance To: GentamicinSisomicin
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Saudi Arabia|Arctium fruticosum rhizosphere
Validation Method: phageome analysis