aac(3)-Ii
aminoglycoside N3'-acetyltransferase
Overview
- Mechanism
- modification of aminoglycoside antibiotics
- Validation Method
- plasmid sequencing and confirmation of aminoglycoside resistance
- Drug Classes
- gentamicin, ASTROMICIN, FORTIMICIN, GENTAMICIN
- Organisms
- Escherichia coli, Sphingopyxis alaskensis RB2256
- Geographic Location
- Toronto, Canada|Vancouver, Canada|India
- Papers
- 2
- Databases
- Reference Gene CatalogResFinder DatabaseReslit
Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada.
The study reports the complete nucleotide sequence of a 92-kilobase plasmid, pC15-1a, which harbors the CTX-M-15 extended-spectrum beta-lactamase, along with other resistance genes such as blaOXA-1, blaTEM-1, aac(6')-Ib, aac(3)-II, and tetA. These genes contribute to multidrug resistance in Escherichia coli strains associated with an outbreak in long-term-care facilities in Toronto, Canada.
Gene Information
- Gene Name
- aac(3)-Ii
- Allele
- AAC(3)-Ii
- Encodes
- aminoglycoside N3'-acetyltransferase
- Source Database
- Reslit
- Mechanism
- modification of aminoglycoside antibiotics
- Confers Resistance To
- gentamicin
- Organisms Tested In
- • Escherichia coli
- Geographic Location
- Toronto, Canada|Vancouver, Canada|India
- Validation Method
- plasmid sequencing and confirmation of aminoglycoside resistance
- Sequence Accession
- AY458016
Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.
Gene Information
- Gene Name
- aac(3)-Ii
- Allele
- AAC(3)-Ii
- Encodes
- aminoglycoside acetyltransferase
- Source Database
- Reslit
- Confers Resistance To
- gentamicin
- Organisms Tested In
- • Escherichia coli
- Validation Method
- PCR and sequencing
Gene Information
- Gene Name
- aac(3)-Ii
- Allele
- AAC(3)-Ii
- Encodes
- aminoglycoside N-acetyltransferase AAC(3)-Ii
- Source Database
- Reference Gene Catalog
- Mechanism
- Enzymatic modification
- Confers Resistance To
- ASTROMICINFORTIMICINGENTAMICIN
- Organisms Tested In
- • Sphingopyxis alaskensis RB2256
- Sequence Accession
- CP000356.1
- Protein Accession
- ABF52347.1
Gene Information
- Gene Name
- aac(3)-Ii
- Allele
- AAC(3)-Ii
- Encodes
- aminoglycoside N-acetyltransferase AAC(3)-Ii
- Source Database
- ResFinder Database
- Mechanism
- Enzymatic modification
- Confers Resistance To
- ASTROMICINFORTIMICINGENTAMICIN
- Organisms Tested In
- • Sphingopyxis alaskensis RB2256
- Sequence Accession
- CP000356.1
- Protein Accession
- ABF52347.1
Gene Information
- Gene Name
- aac(3)-Ii
- Allele
- AAC(3)-Ii
- Encodes
- aminoglycoside N-acetyltransferase AAC(3)-Ii
- Source Database
- Reference Gene Catalog
- Mechanism
- Enzymatic modification
- Confers Resistance To
- ASTROMICINFORTIMICINGENTAMICIN
- Organisms Tested In
- • Sphingopyxis alaskensis RB2256
- Sequence Accession
- CP000356.1
- Protein Accession
- ABF52347.1
Gene Information
- Gene Name
- aac(3)-Ii
- Allele
- AAC(3)-Ii
- Encodes
- aminoglycoside N-acetyltransferase AAC(3)-Ii
- Source Database
- ResFinder Database
- Mechanism
- Enzymatic modification
- Confers Resistance To
- ASTROMICINFORTIMICINGENTAMICIN
- Organisms Tested In
- • Sphingopyxis alaskensis RB2256
- Sequence Accession
- CP000356.1
- Protein Accession
- ABF52347.1
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