Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
N-acetyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| AAC(3)-VIIa | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | aminoglycosides, AMINOGLYCOSIDE +7 | Enterobacteriaceae +1 | Republic of the Congo|United States | 1989, 2010, 2020 | M22999.1 | AAA88552.1 |
| aac(3)-VII | Reslit | 1 | kanamycin, gentamicin +2 | Escherichia coli | - | 2023 | - | - |
Aminoglycoside modifying enzymes.
Review
The paper discusses various aminoglycoside modifying enzymes, particularly focusing on AAC(6')-Ib, AAC(6')-Ib-cr, and AAC(6')-Ib 11, which confer resistance to aminoglycosides like amikacin and gentamicin, and in some cases, quinolones.
Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase gene from Streptomyces rimosus forma paromomycinus.
Research Article
Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase gene from Streptomyces rimosus forma paromomycinus.
Research Article
Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase gene from Streptomyces rimosus forma paromomycinus.
Research Article
Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase gene from Streptomyces rimosus forma paromomycinus.
Research Article
The microbiome and resistome of chimpanzees, gorillas, and humans across host lifestyle and geography.
Research Article
The study identifies novel antibiotic resistance genes, including a gene conferring resistance to colistin, an antibiotic of last resort, in the microbiomes of chimpanzees, gorillas, and humans. It highlights the impact of host lifestyle on the resistome, showing that captive apes have higher abundance and richness of antibiotic resistance genes compared to wild apes.
Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens.
Research Article
The study identifies numerous novel aminoglycoside resistance genes (AMEs) in human pathogens through extensive computational screening of bacterial genomes. Twenty-four out of twenty-eight experimentally tested AMEs conferred resistance to aminoglycosides in E. coli, with seventeen exceeding clinical breakpoints.
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