aac(3)-Xa
aminoglycoside 3-N-acetyltransferase
Overview
- Mechanism
- enhanced transcription due to a point mutation
- Validation Method
- RNA analysis and cloning experiments
- Drug Classes
- kanamycin, AMINOGLYCOSIDE
- Organisms
- Streptomyces griseus SS-1198, Streptomyces lividans TK21, Streptomyces griseus
- Papers
- 1
- Databases
- Card DatabaseReference Gene CatalogReslit
- Mutations
- 1
Mutations
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| - | - | Streptomyces griseus, Streptomyces lividans | - | Reslit | Candidate |
Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.
The study identifies a point mutation in the promoter region of the aac(3)-Xa gene in Streptomyces griseus SS-1198, which increases the transcription level of the gene and leads to kanamycin resistance.
Gene Information
- Gene Name
- aac(3)-Xa
- Allele
- AAC(3)-Xa
- Encodes
- aminoglycoside 3-N-acetyltransferase
- Source Database
- Reslit
- Mechanism
- enhanced transcription due to a point mutation
- Confers Resistance To
- kanamycin
- Organisms Tested In
- • Streptomyces griseus SS-1198• Streptomyces lividans TK21
- Validation Method
- RNA analysis and cloning experiments
Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.
Gene Information
- Gene Name
- aac(3)-Xa
- Allele
- AAC(3)-Xa
- Encodes
- aminoglycoside N-acetyltransferase AAC(3)-Xa, AAC(3)
- Source Database
- Card Database
- Mechanism
- antibiotic inactivation
- Confers Resistance To
- AMINOGLYCOSIDE
- Organisms Tested In
- • Streptomyces griseus
- Sequence Accession
- AB028210.1
- Protein Accession
- BAA78619.1
- Notes
- ARO:3002544
Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.
Gene Information
- Gene Name
- aac(3)-Xa
- Allele
- AAC(3)-Xa
- Encodes
- aminoglycoside N-acetyltransferase AAC(3)-Xa
- Source Database
- Reference Gene Catalog
- Mechanism
- antibiotic inactivation
- Confers Resistance To
- AMINOGLYCOSIDE
- Organisms Tested In
- • Streptomyces griseus
- Sequence Accession
- AB028210.1
- Protein Accession
- BAA78619.1
- Notes
- ARO:3002544
Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.
Gene Information
- Gene Name
- aac(3)-Xa
- Allele
- AAC(3)-Xa
- Encodes
- aminoglycoside N-acetyltransferase AAC(3)-Xa, AAC(3)
- Source Database
- Card Database
- Mechanism
- antibiotic inactivation
- Confers Resistance To
- AMINOGLYCOSIDE
- Organisms Tested In
- • Streptomyces griseus
- Sequence Accession
- AB028210.1
- Protein Accession
- BAA78619.1
- Notes
- ARO:3002544
Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.
Gene Information
- Gene Name
- aac(3)-Xa
- Allele
- AAC(3)-Xa
- Encodes
- aminoglycoside N-acetyltransferase AAC(3)-Xa
- Source Database
- Reference Gene Catalog
- Mechanism
- antibiotic inactivation
- Confers Resistance To
- AMINOGLYCOSIDE
- Organisms Tested In
- • Streptomyces griseus
- Sequence Accession
- AB028210.1
- Protein Accession
- BAA78619.1
- Notes
- ARO:3002544
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