ResLit

aac(6')

aminoglycoside phosphotransferase

NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to aac(6')
AMR Rules
Browse AMR rules for aac(6')
Curation StatusNot Validated

Overview

Drug Classes
gentamicin, tobramycin, amikacin, AMINOGLYCOSIDE, netilmicin, TOBRAMYCIN, AMIKACIN, SISOMICIN, DIBEKACIN, NETILMICIN, kanamycin, sisomicin, KANAMYCIN
Organisms
Staphylococcus aureus, Salmonella enterica subsp. enterica serovar Enteritidis, Escherichia coli +40 more
Alleles
18
Papers
17
Allele Variants18
AllelePapersDrug ClassesOrganismsCountriesYearsStatus
aac6'-aph2"1gentamicin, tobramycin +1Staphylococcus aureusFrance|French West Indies1999Not Validated
AAC(6')-Iy4AMINOGLYCOSIDESalmonella enterica subsp. enterica serovar Enteritidis-1999Not Validated
aac(6')-aph(2'')2gentamicin, tobramycin +2Staphylococcus aureusJapan, Pennsylvania2001, 2004Not Validated
AAC(6')-Ic7gentamicin, tobramycin +7Escherichia coli +1-1992Not Validated
AAC(6')-I306TOBRAMYCIN, AMINOGLYCOSIDE +4Salmonella enterica subsp. enterica serovar Agona-2004Not Validated
AAC(6')-Isa6TOBRAMYCIN, AMIKACIN +1Streptomyces noursei-2004Not Validated
AAC(6')-Iae7TOBRAMYCIN, AMINOGLYCOSIDE +9Pseudomonas aeruginosa +2Japan2005Not Validated
AAC(6')-326TOBRAMYCIN, AMINOGLYCOSIDEPseudomonas aeruginosa-2007Not Validated
AAC(6')-Iaf4AMINOGLYCOSIDEPseudomonas aeruginosa-2009Not Validated
AAC(6')-336TOBRAMYCIN, AMIKACIN +1Pseudomonas aeruginosa-2009Not Validated
AAC(6')-Iaj6TOBRAMYCIN, AMINOGLYCOSIDE +4Pseudomonas aeruginosa-2013Not Validated
AacA472AMINOGLYCOSIDEChamaesiphon minutus PCC 6605-2013Not Validated
aac(6')98AMINOGLYCOSIDESerratia sp. FS14 +33-2015, 2016Not Validated
AacA562TOBRAMYCIN, KANAMYCIN +1Pseudomonas aeruginosa-2023Not Validated
AacA162AMINOGLYCOSIDEAcinetobacter baumannii 1656-2--Not Validated
AAC(6')-Ial2AMINOGLYCOSIDESerratia marcescens--Not Validated
AAC(6')-Iai6TOBRAMYCIN, AMINOGLYCOSIDE +4Pseudomonas aeruginosa--Not Validated
AAC(6')-Iaa6TOBRAMYCIN, AMIKACIN +1Salmonella enterica subsp. enterica serovar Typhimurium str. LT2--Not Validated
Papers17
1

Emergence and spread in French hospitals of methicillin-resistant Staphylococcus aureus with increasing susceptibility to gentamicin and other antibiotics.

PMID 10523533 · 1999

The study identifies the aac6'-aph2" gene as a key determinant of gentamicin resistance in methicillin-resistant Staphylococcus aureus (MRSA) and shows that its absence leads to increased susceptibility to gentamicin and other aminoglycosides.

Gene Information

Gene Name
aac(6')
Allele
aac6'-aph2"
Encodes
aminoglycoside phosphotransferase
Validation Method
hybridization studies

Confers Resistance To

gentamicintobramycinamikacin

Organisms Tested In

• Staphylococcus aureus

Isolation Details

Country
France|French West Indies
2

Activation of the cryptic aac(6')-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion.

PMID 10542165 · 1999

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iy
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iy

Mechanism

antibiotic inactivation

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Enteritidis
3

Activation of the cryptic aac(6')-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion.

PMID 10542165 · 1999

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iy
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iy, AAC(6')

Mechanism

antibiotic inactivation

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Enteritidis
4

Activation of the cryptic aac(6')-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion.

PMID 10542165 · 1999

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iy
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iy, AAC(6')

Mechanism

antibiotic inactivation

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Enteritidis
5

Activation of the cryptic aac(6')-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion.

PMID 10542165 · 1999

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iy
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iy

Mechanism

antibiotic inactivation

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Enteritidis
6

Identification of Aminoglycoside-Modifying Enzymes by Susceptibility Testing: Epidemiology of Methicillin-Resistant Staphylococcus aureus in Japan.

PMID 11526138 · 2001

The study identified aac(6')-aph(2"), ant(4')-I, and aph(3')-III genes as the primary aminoglycoside-modifying enzymes in methicillin-resistant Staphylococcus aureus (MRSA) isolates in Japan, with varying prevalence rates.

Gene Information

Gene Name
aac(6')
Allele
aac(6')-aph(2'')
Encodes
aminoglycoside acetyltransferase/2"-phosphoryltransferase
Validation Method
PCR and MIC testing

Mechanism

modifies aminoglycosides

Confers Resistance To

gentamicintobramycin

Organisms Tested In

• Staphylococcus aureus

Isolation Details

Country
Japan
7

Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens.

PMID 1354954 · 1992

The study characterizes the chromosomal aac(6')-Ic gene from Serratia marcescens, which encodes a 6'-N-acetyltransferase responsible for resistance to gentamicin, tobramycin, and netilmicin.

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Ic
Encodes
6'-N-acetyltransferase
Validation Method
high-pressure liquid chromatographic analysis of extracts from E. coli carrying the gene on a plasmid

Confers Resistance To

gentamicintobramycinnetilmicin

Organisms Tested In

• Escherichia coli
• Serratia marcescens
8

Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens.

PMID 1354954 · 1992

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Ic
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ic

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Serratia marcescens
9

Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens.

PMID 1354954 · 1992

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Ic
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ic, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Serratia marcescens
10

Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens.

PMID 1354954 · 1992

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Ic
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ic

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Serratia marcescens
11

Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens.

PMID 1354954 · 1992

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Ic
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ic

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Serratia marcescens
12

Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens.

PMID 1354954 · 1992

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Ic
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ic

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Serratia marcescens
13

Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens.

PMID 1354954 · 1992

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Ic
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ic, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Serratia marcescens
14

Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania.

PMID 14693550 · 2004

The study reports the second VRSA isolate in the United States, which contains the vanA gene responsible for vancomycin resistance and other resistance genes such as mecA, erm(A), and aac(6')-aph(2").

Gene Information

Gene Name
aac(6')
Allele
aac(6')-aph(2'')
Encodes
aminoglycoside resistance determinant
Validation Method
PCR and DNA sequence analysis

Confers Resistance To

kanamycingentamicintobramycinamikacin

Organisms Tested In

• Staphylococcus aureus

Isolation Details

Country
Pennsylvania
15

Characterization of a Salmonella enterica serovar Agona strain harbouring a class 1 integron containing novel OXA-type beta-lactamase (blaOXA-53) and 6'-N-aminoglycoside acetyltransferase genes [aac(6')-I30].

PMID 15231768 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-I30
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-I30, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Agona
16

Characterization of a Salmonella enterica serovar Agona strain harbouring a class 1 integron containing novel OXA-type beta-lactamase (blaOXA-53) and 6'-N-aminoglycoside acetyltransferase genes [aac(6')-I30].

PMID 15231768 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-I30
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-I30

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Agona
17

Characterization of a Salmonella enterica serovar Agona strain harbouring a class 1 integron containing novel OXA-type beta-lactamase (blaOXA-53) and 6'-N-aminoglycoside acetyltransferase genes [aac(6')-I30].

PMID 15231768 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-I30
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-I30

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Agona
18

Characterization of a Salmonella enterica serovar Agona strain harbouring a class 1 integron containing novel OXA-type beta-lactamase (blaOXA-53) and 6'-N-aminoglycoside acetyltransferase genes [aac(6')-I30].

PMID 15231768 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-I30
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-I30

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Agona
19

Characterization of a Salmonella enterica serovar Agona strain harbouring a class 1 integron containing novel OXA-type beta-lactamase (blaOXA-53) and 6'-N-aminoglycoside acetyltransferase genes [aac(6')-I30].

PMID 15231768 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-I30
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-I30, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Agona
20

Characterization of a Salmonella enterica serovar Agona strain harbouring a class 1 integron containing novel OXA-type beta-lactamase (blaOXA-53) and 6'-N-aminoglycoside acetyltransferase genes [aac(6')-I30].

PMID 15231768 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-I30
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-I30

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Agona
21

Overexpression and characterization of an aminoglycoside 6'-N-acetyltransferase with broad specificity from an epsilon-poly-L-lysine producer, Streptomyces albulus IFO14147.

PMID 15625322 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Isa
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Isa, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Streptomyces noursei
22

Overexpression and characterization of an aminoglycoside 6'-N-acetyltransferase with broad specificity from an epsilon-poly-L-lysine producer, Streptomyces albulus IFO14147.

PMID 15625322 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Isa
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Isa

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Streptomyces noursei
23

Overexpression and characterization of an aminoglycoside 6'-N-acetyltransferase with broad specificity from an epsilon-poly-L-lysine producer, Streptomyces albulus IFO14147.

PMID 15625322 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Isa
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Isa

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Streptomyces noursei
24

Overexpression and characterization of an aminoglycoside 6'-N-acetyltransferase with broad specificity from an epsilon-poly-L-lysine producer, Streptomyces albulus IFO14147.

PMID 15625322 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Isa
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Isa

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Streptomyces noursei
25

Overexpression and characterization of an aminoglycoside 6'-N-acetyltransferase with broad specificity from an epsilon-poly-L-lysine producer, Streptomyces albulus IFO14147.

PMID 15625322 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Isa
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Isa

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Streptomyces noursei
26

Overexpression and characterization of an aminoglycoside 6'-N-acetyltransferase with broad specificity from an epsilon-poly-L-lysine producer, Streptomyces albulus IFO14147.

PMID 15625322 · 2004

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Isa
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Isa, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Streptomyces noursei
27

Multidrug-resistant Pseudomonas aeruginosa strain that caused an outbreak in a neurosurgery ward and its aac(6')-Iae gene cassette encoding a novel aminoglycoside acetyltransferase.

PMID 16127047 · 2005

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iae
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iae

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
28

Multidrug-resistant Pseudomonas aeruginosa strain that caused an outbreak in a neurosurgery ward and its aac(6')-Iae gene cassette encoding a novel aminoglycoside acetyltransferase.

PMID 16127047 · 2005

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iae
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iae, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
29

Multidrug-resistant Pseudomonas aeruginosa strain that caused an outbreak in a neurosurgery ward and its aac(6')-Iae gene cassette encoding a novel aminoglycoside acetyltransferase.

PMID 16127047 · 2005

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iae
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iae

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
30

Multidrug-resistant Pseudomonas aeruginosa strain that caused an outbreak in a neurosurgery ward and its aac(6')-Iae gene cassette encoding a novel aminoglycoside acetyltransferase.

PMID 16127047 · 2005

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iae
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iae

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
31

Multidrug-resistant Pseudomonas aeruginosa strain that caused an outbreak in a neurosurgery ward and its aac(6')-Iae gene cassette encoding a novel aminoglycoside acetyltransferase.

PMID 16127047 · 2005

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iae
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iae

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
32

Multidrug-resistant Pseudomonas aeruginosa strain that caused an outbreak in a neurosurgery ward and its aac(6')-Iae gene cassette encoding a novel aminoglycoside acetyltransferase.

PMID 16127047 · 2005

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iae
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iae, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
33

Multidrug-resistant Pseudomonas aeruginosa strain that caused an outbreak in a neurosurgery ward and its aac(6′)-Iae gene cassette encoding a novel aminoglycoside acetyltransferase.

PMID 16127047 · 2005

The study identifies a novel aminoglycoside acetyltransferase gene, aac(6′)-Iae, which confers resistance to multiple aminoglycosides in a multidrug-resistant Pseudomonas aeruginosa strain.

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iae
Encodes
aminoglycoside acetyltransferase
Validation Method
cloning in E. coli + disk diffusion

Mechanism

acetylation of aminoglycosides

Confers Resistance To

amikacinkanamycinnetilmicinsisomicintobramycin

Organisms Tested In

• Pseudomonas aeruginosa IMCJ2.S1
• Escherichia coli

Isolation Details

Country
Japan
34

Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals.

PMID 17938181 · 2007

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-32
Encodes
aminoglycoside N-acetyltransferase AAC(6')-32, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
35

Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals.

PMID 17938181 · 2007

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-32
Encodes
aminoglycoside N-acetyltransferase AAC(6')-32

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
36

Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals.

PMID 17938181 · 2007

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-32
Encodes
aminoglycoside N-acetyltransferase AAC(6')-32, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
37

Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals.

PMID 17938181 · 2007

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-32
Encodes
aminoglycoside N-acetyltransferase AAC(6')-32

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
38

Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals.

PMID 17938181 · 2007

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-32
Encodes
aminoglycoside N-acetyltransferase AAC(6')-32

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
39

Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals.

PMID 17938181 · 2007

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-32
Encodes
aminoglycoside N-acetyltransferase AAC(6')-32

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
40

AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates.

PMID 19349516 · 2009

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaf
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaf, AAC(6')

Mechanism

antibiotic inactivation

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
41

AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates.

PMID 19349516 · 2009

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaf
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaf

Mechanism

antibiotic inactivation

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
42

AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates.

PMID 19349516 · 2009

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaf
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaf, AAC(6')

Mechanism

antibiotic inactivation

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
43

AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates.

PMID 19349516 · 2009

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaf
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaf

Mechanism

antibiotic inactivation

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
44

Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain.

PMID 19738007 · 2009

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-33
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-33

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
45

Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain.

PMID 19738007 · 2009

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-33
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-33

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
46

Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain.

PMID 19738007 · 2009

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-33
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-33

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
47

Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain.

PMID 19738007 · 2009

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-33
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-33

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
48

Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain.

PMID 19738007 · 2009

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-33
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-33

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
49

Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain.

PMID 19738007 · 2009

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-33
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-33

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Pseudomonas aeruginosa
50

novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.

PMID 23070167 · 2013

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaj
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaj, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
51

novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.

PMID 23070167 · 2013

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaj
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaj

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
52

novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.

PMID 23070167 · 2013

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaj
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaj

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
53

novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.

PMID 23070167 · 2013

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaj
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaj, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
54

novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.

PMID 23070167 · 2013

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaj
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaj

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
55

novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.

PMID 23070167 · 2013

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaj
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaj

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
56

Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.

PMID 23277585 · 2013

Gene Information

Gene Name
aac(6')
Allele
AacA47
Encodes
aminoglycoside 6'-N-acetyltransferase AacA47

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Chamaesiphon minutus PCC 6605
57

Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.

PMID 23277585 · 2013

Gene Information

Gene Name
aac(6')
Allele
AacA47
Encodes
aminoglycoside 6'-N-acetyltransferase AacA47

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Chamaesiphon minutus PCC 6605
58

Comparative genome analyses of Serratia marcescens FS14 reveals its high antagonistic potential.

PMID 25856195 · 2015

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia sp. FS14
59

Comparative genome analyses of Serratia marcescens FS14 reveals its high antagonistic potential.

PMID 25856195 · 2015

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia sp. FS14
60

Complete Genome Sequence of Serratia marcescens SmUNAM836, a Nonpigmented Multidrug-Resistant Strain Isolated from a Mexican Patient with Obstructive Pulmonary Disease.

PMID 26798087 · 2016

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
61

Complete Genome Sequence of Serratia marcescens SmUNAM836, a Nonpigmented Multidrug-Resistant Strain Isolated from a Mexican Patient with Obstructive Pulmonary Disease.

PMID 26798087 · 2016

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
62

Genome Sequence of Stenotrophomonas maltophilia Strain SmAs1, Isolated From the Asian Malaria Mosquito Anopheles stephensi.

PMID 26966198 · 2016

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Stenotrophomonas maltophilia
63

Genome Sequence of Stenotrophomonas maltophilia Strain SmAs1, Isolated From the Asian Malaria Mosquito Anopheles stephensi.

PMID 26966198 · 2016

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Stenotrophomonas maltophilia
64

Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens.

PMID 37537271 · 2023

Gene Information

Gene Name
aac(6')
Allele
AacA56
Encodes
AAC(6')-Ia family aminoglycoside 6'-N-acetyltransferase AacA56

Confers Resistance To

TOBRAMYCINKANAMYCINAMIKACIN

Organisms Tested In

• Pseudomonas aeruginosa
65

Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens.

PMID 37537271 · 2023

Gene Information

Gene Name
aac(6')
Allele
AacA56
Encodes
AAC(6')-Ia family aminoglycoside 6'-N-acetyltransferase AacA56

Confers Resistance To

TOBRAMYCINKANAMYCINAMIKACIN

Organisms Tested In

• Pseudomonas aeruginosa
66
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• uncultured bacterium
67
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia sp. SCBI
68
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens WW4
69
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. 769
70
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces lydicus
71
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces lydicus
72
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
73
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
74
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
75
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. GBA 94-10 4N24
76
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Yersinia mollaretii
77
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Yersinia mollaretii
78
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Yersinia enterocolitica
79
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Yersinia mollaretii
80
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces albidoflavus
81
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. SPB78
82
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens subsp. marcescens Db11
83
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens BIDMC 50
84
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens BIDMC 44
85
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens BIDMC 81
86
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens subsp. marcescens ATCC 13880
87
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
88
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia nematodiphila DZ0503SBS1
89
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia ureilytica
90
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
91
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
92
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. MBRL 601
93
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Kitasatospora griseola
94
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• uncultured bacterium
95
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• uncultured bacterium
96
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Stenotrophomonas maltophilia
97
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. KE1
98
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
99
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia sp. TEL
100
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Stenotrophomonas maltophilia
101
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
102
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
103
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. NRRL F-4711
104
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. NRRL F-4707
105
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Burkholderia vietnamiensis
106
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AacA16
Encodes
AAC(6')-Ia family aminoglycoside 6'-N-acetyltransferase AacA16

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Acinetobacter baumannii 1656-2
107
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Ial
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ial

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
108
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iai
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iai, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
109
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iai
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iai

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
110
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iai
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iai

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
111
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaa
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaa, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
112
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaa
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaa

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
113
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaa
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaa

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
114
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaa
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaa

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
115
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaa
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaa

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
116
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iaa
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaa, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMIKACINAMINOGLYCOSIDE

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
117
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia ureilytica
118
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Escherichia coli
119
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Yersinia mollaretii ATCC 43969
120
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Yersinia mollaretii
121
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. GBA 94-10 4N24
122
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iai
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iai

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
123
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iai
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iai

Mechanism

Enzymatic modification

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
124
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Iai
Encodes
aminoglycoside 6'-N-acetyltransferase AAC(6')-Iai, AAC(6')

Mechanism

Enzymatic modification, antibiotic inactivation

Confers Resistance To

TOBRAMYCINAMINOGLYCOSIDEAMIKACINSISOMICINDIBEKACINNETILMICIN

Organisms Tested In

• Pseudomonas aeruginosa
125
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Yersinia enterocolitica
126
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Yersinia mollaretii
127
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
128
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AAC(6')-Ial
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ial

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
129
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Stenotrophomonas maltophilia
130
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia nematodiphila DZ0503SBS1
131
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
132
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens subsp. marcescens ATCC 13880
133
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens BIDMC 81
134
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens BIDMC 44
135
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens BIDMC 50
136
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens subsp. marcescens Db11
137
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. SPB78
138
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
AacA16
Encodes
AAC(6')-Ia family aminoglycoside 6'-N-acetyltransferase AacA16

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Acinetobacter baumannii 1656-2
139
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia sp. SCBI
140
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens WW4
141
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. 769
142
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
143
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Stenotrophomonas maltophilia
144
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
145
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. NRRL F-4711
146
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. NRRL F-4707
147
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ia family aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces xiaopingdaonensis, Serratia marcescens W2.3, Streptomyces sp. CNS606, Saccharospirillum impatiens DSM 12546, Streptomyces lydicus, Streptomyces sp. NRRL S-1831, Streptomyces albidoflavus, Pseudomonas aeruginosa, Serratia marcescens, Streptomyces sp. CNY228, Streptomyces sulphureus DSM 40104, Variovorax atrisoli 110B, Serratia marcescens MC620, Streptomyces sp. M10, Streptomyces odonnellii
148
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens VGH107
149
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomycetaceae bacterium MP113-05
150
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Burkholderia vietnamiensis
151
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces lydicus
152
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces lydicus
153
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
154
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens EGD-HP20
155
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. MBRL 601
156
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Kitasatospora griseola
157
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
158
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
159
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
160
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces albidoflavus
161
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens SM39
162
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Yersinia mollaretii
163
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens
164
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces sp. KE1
165
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Yersinia mollaretii ATCC 43969
166
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Escherichia coli
167
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ia family aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomyces xiaopingdaonensis, Serratia marcescens W2.3, Streptomyces sp. CNS606, Saccharospirillum impatiens DSM 12546, Streptomyces lydicus, Streptomyces sp. NRRL S-1831, Streptomyces albidoflavus, Pseudomonas aeruginosa, Serratia marcescens, Streptomyces sp. CNY228, Streptomyces sulphureus DSM 40104, Variovorax atrisoli 110B, Serratia marcescens MC620, Streptomyces sp. M10, Streptomyces odonnellii
168
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens VGH107
169
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens SM39
170
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia marcescens EGD-HP20
171
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Streptomycetaceae bacterium MP113-05
172
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• Serratia sp. TEL
173
PMID N/A

Gene Information

Gene Name
aac(6')
Allele
aac(6')
Encodes
aminoglycoside 6'-N-acetyltransferase

Confers Resistance To

AMINOGLYCOSIDE

Organisms Tested In

• uncultured bacterium
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