aac(6')-Iad

aminoglycoside acetyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to aac(6')-Iad

Browse AMR rules for aac(6')-Iad

Validation StatusConfirmed2+ DBs

Overview

Mechanism: acetylation of aminoglycosides
Validation Method: cloning in E. coli + MIC testing
Drug Classes: amikacin, kanamycin, tobramycin, sisomicin, TOBRAMYCIN, AMIKACIN, SISOMICIN, DIBEKACIN, NETILMICIN
Organisms: Escherichia coli, Acinetobacter genospecies 3, Acinetobacter baumannii, Acinetobacter pittii
Geographic Location: France, Japan
Alleles: 2
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
aacA29a	Reslit	1	amikacin, kanamycin +1	Escherichia coli	France	2001	AF263519\|AF263520	-
AAC(6')-Iad	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	7	amikacin, tobramycin +6	Acinetobacter genospecies 3 +2	Japan	2004	AB119105	BAD12078.1

Papers2

1

Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes.

PMID 11158753 · 2001

The study identifies two novel aminoglycoside resistance gene cassettes, aacA29a and aacA29b, which confer resistance to several aminoglycosides. Additionally, the bla(VIM-2) gene, which encodes a carbapenem-hydrolyzing beta-lactamase, was characterized in Pseudomonas aeruginosa isolates.

Gene Information

Gene Name: aac(6')-Iad
Allele: aacA29a
Encodes: aminoglycoside acetyltransferase
Source Database: Reslit
Confers Resistance To: amikacinkanamycintobramycin
Organisms Tested In: • Escherichia coli
Geographic Location: France
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AF263519|AF263520

2

Spread of novel aminoglycoside resistance gene aac(6′)-Iad among Acinetobacter clinical isolates in Japan.

PMID 15155202 · 2004

The study identifies a novel aminoglycoside resistance gene, aac(6')-Iad, which confers resistance to amikacin, tobramycin, sisomicin, and isepamicin in Acinetobacter clinical isolates in Japan.

Gene Information

Gene Name: aac(6')-Iad
Allele: AAC(6')-Iad
Encodes: aminoglycoside 6'-N-acetyltransferase
Source Database: Reslit
Mechanism: acetylation of aminoglycosides
Confers Resistance To: amikacintobramycinsisomicin
Organisms Tested In: • Acinetobacter genospecies 3
• Acinetobacter baumannii
Geographic Location: Japan
Validation Method: high-pressure liquid chromatography assays and MIC testing
Sequence Accession: AB119105

3

Spread of novel aminoglycoside resistance gene aac(6')-Iad among Acinetobacter clinical isolates in Japan.

PMID 15155202 · 2004

Gene Information

Gene Name: aac(6')-Iad
Allele: AAC(6')-Iad
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iad
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICIN
Organisms Tested In: • Acinetobacter pittii
Sequence Accession: AB119105.1
Protein Accession: BAD12078.1
Notes: ARO:3002572

4

Spread of novel aminoglycoside resistance gene aac(6')-Iad among Acinetobacter clinical isolates in Japan.

PMID 15155202 · 2004

Gene Information

Gene Name: aac(6')-Iad
Allele: AAC(6')-Iad
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iad
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICIN
Organisms Tested In: • Acinetobacter pittii
Sequence Accession: AB119105.1
Protein Accession: BAD12078.1
Notes: ARO:3002572

5

Spread of novel aminoglycoside resistance gene aac(6')-Iad among Acinetobacter clinical isolates in Japan.

PMID 15155202 · 2004

Gene Information

Gene Name: aac(6')-Iad
Allele: AAC(6')-Iad
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iad, AAC(6')
Source Database: Card Database
Mechanism: Enzymatic modification, antibiotic inactivation
Confers Resistance To: TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICIN
Organisms Tested In: • Acinetobacter pittii
Sequence Accession: AB119105.1
Protein Accession: BAD12078.1
Notes: ARO:3002572

6

Spread of novel aminoglycoside resistance gene aac(6')-Iad among Acinetobacter clinical isolates in Japan.

PMID 15155202 · 2004

Gene Information

Gene Name: aac(6')-Iad
Allele: AAC(6')-Iad
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iad
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICIN
Organisms Tested In: • Acinetobacter pittii
Sequence Accession: AB119105.1
Protein Accession: BAD12078.1
Notes: ARO:3002572

7

Spread of novel aminoglycoside resistance gene aac(6')-Iad among Acinetobacter clinical isolates in Japan.

PMID 15155202 · 2004

Gene Information

Gene Name: aac(6')-Iad
Allele: AAC(6')-Iad
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iad
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICIN
Organisms Tested In: • Acinetobacter pittii
Sequence Accession: AB119105.1
Protein Accession: BAD12078.1
Notes: ARO:3002572

8

Spread of novel aminoglycoside resistance gene aac(6')-Iad among Acinetobacter clinical isolates in Japan.

PMID 15155202 · 2004

Gene Information

Gene Name: aac(6')-Iad
Allele: AAC(6')-Iad
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iad, AAC(6')
Source Database: Card Database
Mechanism: Enzymatic modification, antibiotic inactivation
Confers Resistance To: TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICIN
Organisms Tested In: • Acinetobacter pittii
Sequence Accession: AB119105.1
Protein Accession: BAD12078.1
Notes: ARO:3002572

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