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aac(6')-Ian

aminoglycoside acetyltransferase

NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to aac(6')-Ian
AMR Rules
Browse AMR rules for aac(6')-Ian
Validation StatusConfirmed2+ DBs

Overview

Mechanism
Enzymatic modification
Validation Method
cloning in E. coli + MIC testing
Drug Classes
amikacin, kanamycin, tobramycin, kanamycin a, sisomicin, TOBRAMYCIN, AMIKACIN, SISOMICIN, DIBEKACIN, NETILMICIN, KANAMYCIN
Organisms
Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens, Pseudochrobactrum sp. AO18b
Geographic Location
France
Alleles
2
Papers
4
Databases
Card DatabaseReference Gene CatalogResFinder DatabaseReslit
Allele Variants2
AlleleDatabasePapersDrug ClassesOrganismsCountriesYearsSequence AccessionProtein Accession
aacA29b
Reslit
2amikacin, kanamycin +3Escherichia coli +1France2001, 2003AF263519|AF263520-
AAC(6')-Ian
Card DatabaseReference Gene CatalogResFinder Database
8TOBRAMYCIN, AMIKACIN +4Serratia marcescens +1-1997, 2015AP014611.1BAQ22025.1
Papers4
1

Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes.

PMID 11158753 · 2001

The study identifies two novel aminoglycoside resistance gene cassettes, aacA29a and aacA29b, which confer resistance to several aminoglycosides. Additionally, the bla(VIM-2) gene, which encodes a carbapenem-hydrolyzing beta-lactamase, was characterized in Pseudomonas aeruginosa isolates.

Gene Information

Gene Name
aac(6')-Ian
Allele
aacA29b
Encodes
aminoglycoside acetyltransferase
Source Database
Reslit
Confers Resistance To
amikacinkanamycintobramycin
Organisms Tested In
• Escherichia coli
Geographic Location
France
Validation Method
cloning in E. coli + MIC testing
Sequence Accession
AF263519|AF263520
2

Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase.

PMID 12709325 · 2003

The study identifies the aacA29b gene, which confers aminoglycoside resistance by tightly binding the drugs rather than through enzymatic acetylation.

Gene Information

Gene Name
aac(6')-Ian
Allele
aacA29b
Encodes
aminoglycoside acetyltransferase
Source Database
Reslit
Confers Resistance To
tobramycinkanamycin asisomicinamikacin
Organisms Tested In
• Escherichia coli
• Pseudomonas aeruginosa
Validation Method
cloning in E. coli + MIC testing
3

New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.

PMID 25576529 · 2015

Gene Information

Gene Name
aac(6')-Ian
Allele
AAC(6')-Ian
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ian
Source Database
ResFinder Database
Mechanism
Enzymatic modification
Confers Resistance To
TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICINKANAMYCIN
Organisms Tested In
• Serratia marcescens
Sequence Accession
AP014611.1
Protein Accession
BAQ22025.1
Notes
ARO:3003200
4

New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.

PMID 25576529 · 2015

Gene Information

Gene Name
aac(6')-Ian
Allele
AAC(6')-Ian
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ian, AAC(6')
Source Database
Card Database
Mechanism
Enzymatic modification, antibiotic inactivation
Confers Resistance To
TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICINKANAMYCIN
Organisms Tested In
• Serratia marcescens
Sequence Accession
AP014611.1
Protein Accession
BAQ22025.1
Notes
ARO:3003200
5

New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.

PMID 25576529 · 2015

Gene Information

Gene Name
aac(6')-Ian
Allele
AAC(6')-Ian
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ian, AAC(6')
Source Database
Card Database
Mechanism
Enzymatic modification, antibiotic inactivation
Confers Resistance To
TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICINKANAMYCIN
Organisms Tested In
• Serratia marcescens
Sequence Accession
AP014611.1
Protein Accession
BAQ22025.1
Notes
ARO:3003200
6

New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.

PMID 25576529 · 2015

Gene Information

Gene Name
aac(6')-Ian
Allele
AAC(6')-Ian
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ian
Source Database
Reference Gene Catalog
Mechanism
Enzymatic modification
Confers Resistance To
TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICINKANAMYCIN
Organisms Tested In
• Serratia marcescens
Sequence Accession
AP014611.1
Protein Accession
BAQ22025.1
Notes
ARO:3003200
7

New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.

PMID 25576529 · 2015

Gene Information

Gene Name
aac(6')-Ian
Allele
AAC(6')-Ian
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ian
Source Database
Reference Gene Catalog
Mechanism
Enzymatic modification
Confers Resistance To
TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICINKANAMYCIN
Organisms Tested In
• Serratia marcescens
Sequence Accession
AP014611.1
Protein Accession
BAQ22025.1
Notes
ARO:3003200
8

New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.

PMID 25576529 · 2015

Gene Information

Gene Name
aac(6')-Ian
Allele
AAC(6')-Ian
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ian
Source Database
ResFinder Database
Mechanism
Enzymatic modification
Confers Resistance To
TOBRAMYCINAMIKACINSISOMICINDIBEKACINNETILMICINKANAMYCIN
Organisms Tested In
• Serratia marcescens
Sequence Accession
AP014611.1
Protein Accession
BAQ22025.1
Notes
ARO:3003200
9

Cloning and characterization of an aminoglycoside 6'-N-acetyltransferase gene from Citrobacter freundii which confers an altered resistance profile.

PMID 9371347 · 1997

Gene Information

Gene Name
aac(6')-Ian
Allele
AAC(6')-Ian
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ian
Source Database
Reference Gene Catalog
Confers Resistance To
TOBRAMYCINKANAMYCINAMIKACIN
Organisms Tested In
• Pseudochrobactrum sp. AO18b
Sequence Accession
ANNO01000478.1
10

Cloning and characterization of an aminoglycoside 6'-N-acetyltransferase gene from Citrobacter freundii which confers an altered resistance profile.

PMID 9371347 · 1997

Gene Information

Gene Name
aac(6')-Ian
Allele
AAC(6')-Ian
Encodes
aminoglycoside N-acetyltransferase AAC(6')-Ian
Source Database
Reference Gene Catalog
Confers Resistance To
TOBRAMYCINKANAMYCINAMIKACIN
Organisms Tested In
• Pseudochrobactrum sp. AO18b
Sequence Accession
ANNO01000478.1
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