ResLit

aac(6')-Ib-cr

fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr6

NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to aac(6')-Ib-cr
AMR Rules
Browse AMR rules for aac(6')-Ib-cr
Curation StatusNot Validated

Overview

Drug Classes
QUINOLONE, KANAMYCIN, AMIKACIN, TOBRAMYCIN
Organisms
Escherichia coli, Pseudomonas aeruginosa, Aeromonas media +5 more
Alleles
10
Papers
3
Allele Variants10
AllelePapersDrug ClassesOrganismsCountriesYearsStatus
AAC(6')-Ib-cr62QUINOLONE, KANAMYCIN +2Escherichia coli-2009Not Validated
AAC(6')-Ib-cr54QUINOLONE, KANAMYCIN +2Pseudomonas aeruginosa-2008Not Validated
AAC(6')-Ib-cr32QUINOLONE, KANAMYCIN +2Aeromonas media-2012Not Validated
AAC(6')-Ib-cr94QUINOLONE, KANAMYCIN +2Serratia marcescens--Not Validated
AAC(6')-Ib-cr2QUINOLONE, KANAMYCIN +2Stenotrophomonas maltophilia--Not Validated
AAC(6')-Ib-cr112QUINOLONE, KANAMYCIN +2Proteus mirabilis--Not Validated
AAC(6')-Ib-cr42QUINOLONE, KANAMYCIN +2Enterobacter hormaechei subsp. steigerwaltii--Not Validated
AAC(6')-Ib-cr72QUINOLONE, KANAMYCIN +2Escherichia coli--Not Validated
AAC(6')-Ib-cr84QUINOLONE, KANAMYCIN +2Salmonella enterica subsp. enterica serovar Derby--Not Validated
AAC(6')-Ib-cr102QUINOLONE, KANAMYCIN +2Escherichia coli--Not Validated
Papers3
1

dfrA27, a new integron-associated trimethoprim resistance gene from Escherichia coli.

PMID 19008256 · 2009

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr6
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr6

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Escherichia coli
2

dfrA27, a new integron-associated trimethoprim resistance gene from Escherichia coli.

PMID 19008256 · 2009

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr6
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr6

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Escherichia coli
3

Identification of PER-1 extended-spectrum beta-lactamase producing Pseudomonas aeruginosa clinical isolates of the international clonal complex CC11 from Hungary and Serbia.

PMID 19049645 · 2008

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr5
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr5, AAC(6');AAC(6')-Ib-cr

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Pseudomonas aeruginosa
4

Identification of PER-1 extended-spectrum beta-lactamase producing Pseudomonas aeruginosa clinical isolates of the international clonal complex CC11 from Hungary and Serbia.

PMID 19049645 · 2008

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr5
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr5, AAC(6');AAC(6')-Ib-cr

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Pseudomonas aeruginosa
5

Identification of PER-1 extended-spectrum beta-lactamase producing Pseudomonas aeruginosa clinical isolates of the international clonal complex CC11 from Hungary and Serbia.

PMID 19049645 · 2008

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr5
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr5

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Pseudomonas aeruginosa
6

Identification of PER-1 extended-spectrum beta-lactamase producing Pseudomonas aeruginosa clinical isolates of the international clonal complex CC11 from Hungary and Serbia.

PMID 19049645 · 2008

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr5
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr5

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Pseudomonas aeruginosa
7

Novel gene cassettes and integrons in antibiotic-resistant bacteria isolated from urban wastewaters.

PMID 22127350 · 2012

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr3
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr3

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Aeromonas media
8

Novel gene cassettes and integrons in antibiotic-resistant bacteria isolated from urban wastewaters.

PMID 22127350 · 2012

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr3
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr3

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Aeromonas media
9
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr9
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr9, AAC(6');AAC(6')-Ib-cr

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Serratia marcescens
10
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Stenotrophomonas maltophilia
11
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Stenotrophomonas maltophilia
12
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr11
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr11

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Proteus mirabilis
13
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr4
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr4

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Enterobacter hormaechei subsp. steigerwaltii
14
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr7
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr7

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Escherichia coli
15
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr8
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr8

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Derby
16
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr8
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr8, AAC(6');AAC(6')-Ib-cr

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Derby
17
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr9
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr9

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Serratia marcescens
18
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr9
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr9, AAC(6');AAC(6')-Ib-cr

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Serratia marcescens
19
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr10
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr10

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Escherichia coli
20
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr10
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr10

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Escherichia coli
21
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr11
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr11

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Proteus mirabilis
22
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr4
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr4

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Enterobacter hormaechei subsp. steigerwaltii
23
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr7
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr7

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Escherichia coli
24
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr8
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr8

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Derby
25
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr8
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr8, AAC(6');AAC(6')-Ib-cr

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Salmonella enterica subsp. enterica serovar Derby
26
PMID N/A

Gene Information

Gene Name
aac(6')-Ib-cr
Allele
AAC(6')-Ib-cr9
Encodes
fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr9

Mechanism

antibiotic inactivation

Confers Resistance To

QUINOLONEKANAMYCINAMIKACINTOBRAMYCIN

Organisms Tested In

• Serratia marcescens
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