aac(6')-Ie/aph(2'')
bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to aac(6')-Ie/aph(2'')
AMR Rules
Browse AMR rules for aac(6')-Ie/aph(2'')
Validation StatusConfirmed2+ DBs
Overview
- Mechanism
- Enzymatic modification
- Drug Classes
- TOBRAMYCIN, KANAMYCIN, AMIKACIN, GENTAMICIN, ISEPAMICIN, STREPTOMYCIN, DIBEKACIN, NETILMICIN, FORTIMICIN
- Organisms
- Staphylococcus warneri, Macrococcoides caseolyticum JCSC5402, Staphylococcus aureus, Campylobacter jejuni, Clostridioides difficile
- Alleles
- 3
- Papers
- 3
- Databases
- Card DatabaseReference Gene CatalogResFinder Database
Allele Variants3
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| aac(6')-Ie/aph(2'')-Ia | Card DatabaseReference Gene CatalogResFinder Database | 14 | TOBRAMYCIN, KANAMYCIN +7 | Staphylococcus warneri +2 | - | 1987, 2003, 2009 | AJ536195.1 | CAD60196.1 |
| aac(6')-Ie/aph(2'')-If2 | Reference Gene Catalog | 2 | TOBRAMYCIN, KANAMYCIN +2 | Campylobacter jejuni | - | - | KF652095.1 | AGV79342.1 |
| aac(6')-Ie/aph(2'') | Reference Gene Catalog | 2 | TOBRAMYCIN, KANAMYCIN +2 | Clostridioides difficile | - | - | MF547665.1 | AUV57982.1 |
Papers3
1
Molecular analysis of the plasmid-borne aacA/aphD resistance gene region of coagulase-negative staphylococci from chickens.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- Reference Gene Catalog
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Staphylococcus warneri
- Sequence Accession
- AJ536195.1
- Protein Accession
- CAD60196.1
- Notes
- Bifunctional aac(6')-Ie-aph(2'')-Ia
2
Molecular analysis of the plasmid-borne aacA/aphD resistance gene region of coagulase-negative staphylococci from chickens.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- Reference Gene Catalog
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Staphylococcus warneri
- Sequence Accession
- AJ536195.1
- Protein Accession
- CAD60196.1
- Notes
- Bifunctional aac(6')-Ie-aph(2'')-Ia
3
Molecular analysis of the plasmid-borne aacA/aphD resistance gene region of coagulase-negative staphylococci from chickens.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- ResFinder Database
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Staphylococcus warneri
- Sequence Accession
- AJ536195.1
- Protein Accession
- CAD60196.1
- Notes
- Bifunctional aac(6')-Ie-aph(2'')-Ia
4
Molecular analysis of the plasmid-borne aacA/aphD resistance gene region of coagulase-negative staphylococci from chickens.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- ResFinder Database
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Staphylococcus warneri
- Sequence Accession
- AJ536195.1
- Protein Accession
- CAD60196.1
- Notes
- Bifunctional aac(6')-Ie-aph(2'')-Ia
5
Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, [corrected] reflecting the ancestral genome of the human-pathogenic staphylococci.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- ResFinder Database
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Macrococcoides caseolyticum JCSC5402
- Sequence Accession
- AP009486.1
- Protein Accession
- BAH18719.1
- Notes
- Bifunctional aac(6')-Ie-aph(2'')-Ia
6
Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, [corrected] reflecting the ancestral genome of the human-pathogenic staphylococci.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- ResFinder Database
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Macrococcoides caseolyticum JCSC5402
- Sequence Accession
- AP009486.1
- Protein Accession
- BAH18719.1
- Notes
- Bifunctional aac(6')-Ie-aph(2'')-Ia
7
Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, [corrected] reflecting the ancestral genome of the human-pathogenic staphylococci.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- Reference Gene Catalog
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Macrococcoides caseolyticum JCSC5402
- Sequence Accession
- AP009486.1
- Protein Accession
- BAH18719.1
- Notes
- Bifunctional aac(6')-Ie-aph(2'')-Ia
8
Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, [corrected] reflecting the ancestral genome of the human-pathogenic staphylococci.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- Reference Gene Catalog
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Macrococcoides caseolyticum JCSC5402
- Sequence Accession
- AP009486.1
- Protein Accession
- BAH18719.1
- Notes
- Bifunctional aac(6')-Ie-aph(2'')-Ia
9
The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: expression and nucleotide sequence analysis.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- Reference Gene Catalog
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINISEPAMICINSTREPTOMYCINAMIKACINDIBEKACINNETILMICINFORTIMICINKANAMYCINGENTAMICIN
- Organisms Tested In
- • Staphylococcus aureus
- Sequence Accession
- GU565967.1
- Protein Accession
- AAA88548.1
- Notes
- Alternative name aac(6')-bifunctional, aac(6')-Ie, aacA-aphD, aac(6')-Ie-aph(2'')-Ia
10
The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: expression and nucleotide sequence analysis.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- ResFinder Database
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINISEPAMICINSTREPTOMYCINAMIKACINDIBEKACINNETILMICINFORTIMICINKANAMYCINGENTAMICIN
- Organisms Tested In
- • Staphylococcus aureus
- Sequence Accession
- GU565967.1
- Protein Accession
- AAA88548.1
- Notes
- Alternative name aac(6')-bifunctional, aac(6')-Ie, aacA-aphD, aac(6')-Ie-aph(2'')-Ia
11
The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: expression and nucleotide sequence analysis.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- Card Database
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINISEPAMICINSTREPTOMYCINAMIKACINDIBEKACINNETILMICINFORTIMICINKANAMYCINGENTAMICIN
- Organisms Tested In
- • Staphylococcus aureus
- Sequence Accession
- GU565967.1
- Protein Accession
- AAA88548.1
- Notes
- Alternative name aac(6')-bifunctional, aac(6')-Ie, aacA-aphD, aac(6')-Ie-aph(2'')-Ia
12
The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: expression and nucleotide sequence analysis.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- Reference Gene Catalog
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINISEPAMICINSTREPTOMYCINAMIKACINDIBEKACINNETILMICINFORTIMICINKANAMYCINGENTAMICIN
- Organisms Tested In
- • Staphylococcus aureus
- Sequence Accession
- GU565967.1
- Protein Accession
- AAA88548.1
- Notes
- Alternative name aac(6')-bifunctional, aac(6')-Ie, aacA-aphD, aac(6')-Ie-aph(2'')-Ia
13
The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: expression and nucleotide sequence analysis.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- ResFinder Database
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINISEPAMICINSTREPTOMYCINAMIKACINDIBEKACINNETILMICINFORTIMICINKANAMYCINGENTAMICIN
- Organisms Tested In
- • Staphylococcus aureus
- Sequence Accession
- GU565967.1
- Protein Accession
- AAA88548.1
- Notes
- Alternative name aac(6')-bifunctional, aac(6')-Ie, aacA-aphD, aac(6')-Ie-aph(2'')-Ia
14
The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: expression and nucleotide sequence analysis.
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-Ia
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie/aminoglycoside O-phosphotransferase APH(2'')-Ia
- Source Database
- Card Database
- Mechanism
- Enzymatic modification
- Confers Resistance To
- TOBRAMYCINISEPAMICINSTREPTOMYCINAMIKACINDIBEKACINNETILMICINFORTIMICINKANAMYCINGENTAMICIN
- Organisms Tested In
- • Staphylococcus aureus
- Sequence Accession
- GU565967.1
- Protein Accession
- AAA88548.1
- Notes
- Alternative name aac(6')-bifunctional, aac(6')-Ie, aacA-aphD, aac(6')-Ie-aph(2'')-Ia
15
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-If2
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie2/aminoglycoside O-phosphotransferase APH(2'')-If2
- Source Database
- Reference Gene Catalog
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Campylobacter jejuni
- Sequence Accession
- KF652095.1
- Protein Accession
- AGV79342.1
16
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')
- Encodes
- bifunctional AAC(6')-Ie family aminoglycoside N-acetyltransferase/APH(2'') family aminoglycoside O-phosphotransferase
- Source Database
- Reference Gene Catalog
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Clostridioides difficile
- Sequence Accession
- MF547665.1
- Protein Accession
- AUV57982.1
17
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')
- Encodes
- bifunctional AAC(6')-Ie family aminoglycoside N-acetyltransferase/APH(2'') family aminoglycoside O-phosphotransferase
- Source Database
- Reference Gene Catalog
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Clostridioides difficile
- Sequence Accession
- MF547665.1
- Protein Accession
- AUV57982.1
18
Gene Information
- Gene Name
- aac(6')-Ie/aph(2'')
- Allele
- aac(6')-Ie/aph(2'')-If2
- Encodes
- bifunctional aminoglycoside N-acetyltransferase AAC(6')-Ie2/aminoglycoside O-phosphotransferase APH(2'')-If2
- Source Database
- Reference Gene Catalog
- Confers Resistance To
- TOBRAMYCINKANAMYCINAMIKACINGENTAMICIN
- Organisms Tested In
- • Campylobacter jejuni
- Sequence Accession
- KF652095.1
- Protein Accession
- AGV79342.1
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