aac(6')-Iz

aminoglycoside N-acetyltransferase AAC(6')-Iz

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: mutant analysis and complementation
Drug Classes: TOBRAMYCIN, AMIKACIN, aminoglycosides
Organisms: Stenotrophomonas maltophilia EPM1, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia K279a, Stenotrophomonas maltophilia K279a
Geographic Location: Taiwan|North America|South America|Europe|Asia|Australia
Papers: 6
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers6

PMID N/A

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia EPM1
Sequence Accession: AMXM01000008.1
Protein Accession: EMF61681.1

PMID N/A

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: CP008838.1
Protein Accession: AIL09067.1

PMID N/A

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: HQ424462.1
Protein Accession: ADQ43423.1

PMID N/A

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: JVWJ01000294.1

Characterization of the chromosomal aac(6')-Iz gene of Stenotrophomonas maltophilia.

Research Article

PMID 10508008 · 1999

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: AF140221.1
Protein Accession: AAD52985.1
Notes: ARO:3002570

Characterization of the chromosomal aac(6')-Iz gene of Stenotrophomonas maltophilia.

Research Article

PMID 10508008 · 1999

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz, AAC(6')
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: AF140221.1
Protein Accession: AAD52985.1
Notes: ARO:3002570

Characterization of the chromosomal aac(6')-Iz gene of Stenotrophomonas maltophilia., The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants.

Research Article

PMID 10508008, 18419807 · 1999

Gene Information

Gene Name: aac(6')-Iz
Allele: aac(6')-Iz
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: TOBRAMYCINAMIKACIN
Organisms Tested In: • Stenotrophomonas maltophilia, Stenotrophomonas maltophilia K279a
Sequence Accession: AF140221, AB971834
Notes: Chromosomal in Stenotrophomonas maltophilia, Chromosomal in Stenotrophomonas maltophilia, Alternative name aac(6')-Iak

The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants.

Research Article

PMID 18419807 · 2008

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia K279a
Sequence Accession: AB971834.1
Protein Accession: BAP12403.1

Antimicrobial Resistance in Stenotrophomonas maltophilia: Mechanisms, Clinical Implications, and Potential Therapeutic Strategies

Review

PMID 22232370 · 2023

The paper discusses the multidrug-resistant nature of Stenotrophomonas maltophilia, highlighting its resistance to various antibiotics including β-lactams, fluoroquinolones, aminoglycosides, and polymyxins. It emphasizes the challenges in treating infections caused by this pathogen due to its intrinsic resistance mechanisms and the need for alternative therapeutic approaches.

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: acetyltransferase
Source Database: Reslit
Confers Resistance To: aminoglycosides
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: Taiwan|North America|South America|Europe|Asia|Australia
Validation Method: mutant analysis and complementation

Acquired resistance of Stenotrophomonas maltophilia to antimicrobials induced by herbicide paraquat dichloride.

Research Article

PMID 39196988 · 2024

Exposure of Stenotrophomonas maltophilia to paraquat induces multidrug resistance through genetic mutations affecting efflux pumps, ribosomal proteins, and metabolic enzymes.

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: Aminoglycoside 6'-N-acetyltransferase
Source Database: Reslit
Confers Resistance To: aminoglycosides
Organisms Tested In: • Stenotrophomonas maltophilia
Validation Method: real-time RT-PCR

Genomic analysis of contaminant Stenotrophomonas maltophilia, from placental swab culture, carrying antibiotic resistance: a potential hospital laboratory contaminant.

Research Article

PMID 40594762 · 2025

The study identified six antibiotic resistance genes in Stenotrophomonas maltophilia RAOG732, including aac(6')-Iz, aac(6')-Ib7, aph(3')-IIc, oqxB, sul1, and blaL1, which conferred resistance to aminoglycosides, fluoroquinolones, folate synthesis inhibitors, and beta-lactams.

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: Aminoglycoside-6'-acetyltransferase
Source Database: Reslit
Mechanism: Drug modification
Confers Resistance To: aminoglycosides
Organisms Tested In: • Stenotrophomonas maltophilia
Validation Method: Genome sequencing and susceptibility testing
Sequence Accession: CP079201

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aac(6')-Iz

aminoglycoside N-acetyltransferase AAC(6')-Iz

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to aac(6')-Iz

AMR Rules

Browse AMR rules for aac(6')-Iz

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: mutant analysis and complementation
Drug Classes: TOBRAMYCIN, AMIKACIN, aminoglycosides
Organisms: Stenotrophomonas maltophilia EPM1, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia K279a, Stenotrophomonas maltophilia K279a
Geographic Location: Taiwan|North America|South America|Europe|Asia|Australia
Papers: 6
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers6

PMID N/A

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia EPM1
Sequence Accession: AMXM01000008.1
Protein Accession: EMF61681.1

PMID N/A

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: CP008838.1
Protein Accession: AIL09067.1

PMID N/A

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: HQ424462.1
Protein Accession: ADQ43423.1

PMID N/A

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: JVWJ01000294.1

Characterization of the chromosomal aac(6')-Iz gene of Stenotrophomonas maltophilia.

Research Article

PMID 10508008 · 1999

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: AF140221.1
Protein Accession: AAD52985.1
Notes: ARO:3002570

Characterization of the chromosomal aac(6')-Iz gene of Stenotrophomonas maltophilia.

Research Article

PMID 10508008 · 1999

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz, AAC(6')
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia
Sequence Accession: AF140221.1
Protein Accession: AAD52985.1
Notes: ARO:3002570

Research Article

PMID 10508008, 18419807 · 1999

Gene Information

Gene Name: aac(6')-Iz
Allele: aac(6')-Iz
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: TOBRAMYCINAMIKACIN
Organisms Tested In: • Stenotrophomonas maltophilia, Stenotrophomonas maltophilia K279a
Sequence Accession: AF140221, AB971834
Notes: Chromosomal in Stenotrophomonas maltophilia, Chromosomal in Stenotrophomonas maltophilia, Alternative name aac(6')-Iak

The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants.

Research Article

PMID 18419807 · 2008

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: aminoglycoside N-acetyltransferase AAC(6')-Iz
Source Database: Reference Gene Catalog
Confers Resistance To: TOBRAMYCIN
Organisms Tested In: • Stenotrophomonas maltophilia K279a
Sequence Accession: AB971834.1
Protein Accession: BAP12403.1

Antimicrobial Resistance in Stenotrophomonas maltophilia: Mechanisms, Clinical Implications, and Potential Therapeutic Strategies

Review

PMID 22232370 · 2023

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: acetyltransferase
Source Database: Reslit
Confers Resistance To: aminoglycosides
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: Taiwan|North America|South America|Europe|Asia|Australia
Validation Method: mutant analysis and complementation

Acquired resistance of Stenotrophomonas maltophilia to antimicrobials induced by herbicide paraquat dichloride.

Research Article

PMID 39196988 · 2024

Exposure of Stenotrophomonas maltophilia to paraquat induces multidrug resistance through genetic mutations affecting efflux pumps, ribosomal proteins, and metabolic enzymes.

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: Aminoglycoside 6'-N-acetyltransferase
Source Database: Reslit
Confers Resistance To: aminoglycosides
Organisms Tested In: • Stenotrophomonas maltophilia
Validation Method: real-time RT-PCR

Genomic analysis of contaminant Stenotrophomonas maltophilia, from placental swab culture, carrying antibiotic resistance: a potential hospital laboratory contaminant.

Research Article

PMID 40594762 · 2025

Gene Information

Gene Name: aac(6')-Iz
Allele: AAC(6')-Iz
Encodes: Aminoglycoside-6'-acetyltransferase
Source Database: Reslit
Mechanism: Drug modification
Confers Resistance To: aminoglycosides
Organisms Tested In: • Stenotrophomonas maltophilia
Validation Method: Genome sequencing and susceptibility testing
Sequence Accession: CP079201

Comments (0)

No comments yet. Be the first to comment!

aac(6')-Iz

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aac(6')-Iz

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