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ResLit

aac(6)ie-aph(2)ia

aminoglycoside modifying enzyme

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to aac(6)ie-aph(2)ia

AMR Rules

Browse AMR rules for aac(6)ie-aph(2)ia

Validation StatusSupported

Overview

Validation Method: multiplex PCR and phenotypic testing
Drug Classes: Gentamicin, Aminoglycoside, Tobramycin
Organisms: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Staphylococcus pseudintermedius
Geographic Location: Germany, Iran, Northwest Iran, Poland
Alleles: 2
Papers: 4
Databases: Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
aac(6')Ie-aph(2'')Ia	Reslit	2	Gentamicin	Enterococcus faecalis +1	Northwest Iran, Iran	2012, 2013	-	-
aac(6')Ie-aph(2")Ia	Reslit	2

Papers4

Molecular screening of virulence genes in high-level gentamicin-resistant Enterococcus faecalis and Enterococcus faecium isolated from clinical specimens in Northwest Iran.

PMID 22664433 · 2012

The study identified aac(6')Ie-aph(2'')Ia as the primary gene responsible for high-level gentamicin resistance in Enterococcus faecalis and Enterococcus faecium isolates.

Gene Information

Gene Name: aac(6)ie-aph(2)ia
Allele: aac(6')Ie-aph(2'')Ia
Encodes: aminoglycoside modifying enzyme
Source Database: Reslit
Confers Resistance To: Gentamicin
Organisms Tested In: • Enterococcus faecalis
• Enterococcus faecium
Geographic Location: Northwest Iran
Validation Method: multiplex PCR and phenotypic testing

High level of gentamicin resistance (HLGR) among enterococcus strains isolated from clinical specimens.

PMID 23668465 · 2013

The study identifies the aac(6')Ie-aph(2'')Ia gene as a significant factor in high-level gentamicin resistance (HLGR) among enterococcal isolates.

Gene Information

Gene Name: aac(6)ie-aph(2)ia
Allele: aac(6')Ie-aph(2'')Ia
Encodes: aminoglycoside-modifying enzyme
Source Database: Reslit
Confers Resistance To: Gentamicin
Organisms Tested In: • Enterococcus faecalis
• Enterococcus faecium
Geographic Location: Iran
Validation Method: PCR and sequencing

Antimicrobial resistance and virulence factors in livestock-associated MRSA from German dairy farms

PMID 33488532 · 2021

The study identified various antimicrobial resistance genes in livestock-associated MRSA from German dairy farms, including mecA, fexA, tet(K), tet(M), vga(A), vga(E), dfrG, dfrK, aac(6')Ie-aph(2")Ia, str, spc, lsa(E), and erm(A). These genes conferred resistance to beta-lactams, chloramphenicol, tetracyclines, pleuromutilins, trimethoprim, aminoglycosides, streptomycin, spectinomycin, macrolides, lincosamides, and streptogramin B.

Gene Information

Gene Name: aac(6)ie-aph(2)ia
Allele: aac(6')Ie-aph(2")Ia
Encodes: aminoglycoside modifying enzyme
Source Database: Reslit
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Germany
Validation Method: experimental validation via PCR and phenotypic resistance testing
Sequence Accession: PRJNA634452

Epidemiology of Staphylococcus pseudintermedius in cats in Poland.

PMID 34556720 · 2021

The study characterized the antibiotic resistance profiles of Staphylococcus pseudintermedius isolates from cats in Poland, identifying several resistance genes including blaZ, mecA, aac(6')Ie-aph(2")Ia, ermB, tet(L), and tet(M).

Gene Information

Gene Name: aac(6)ie-aph(2)ia
Allele: aac(6')Ie-aph(2")Ia
Encodes: aminoglycoside modifying enzyme
Source Database: Reslit
Confers Resistance To: GentamicinTobramycin
Organisms Tested In: • Staphylococcus pseudintermedius
Geographic Location: Poland
Validation Method: PCR and MIC testing
Sequence Accession: MK681217.1|MK681218.1|MK681219.1|MK681220.1|MK681221.1|MK681222.1|MK681223.1|MK447569.1|MK447570.1|MK447571.1|MK447572.1|MK447573.1|MK447574.1|MK447575.1|MK447576.1|MK447577.1|MK447578.1|MK447579.1|MK447580.1|MK447581.1|MK447582.1|MK447583.1|MK447584.1|MK447585.1|MK447586.1|MK447587.1|MK447588.1|MK447589.1|MK447590.1|MK447591.1|MK447592.1|MK447593.1|MK447594.1