aacA1

aminoglycoside 6'-acetyltransferase

Validation StatusSupported

Overview

Validation Method: cloning in E. coli DH5αMCR and antimicrobial susceptibility assays
Drug Classes: Kanamycin, Amikacin, Netilmicin, Sisomicin, Tobramycin, Gentamicin
Organisms: Corynebacterium resistens DSM 45100, Corynebacterium glutamicum ATCC 13032, Acinetobacter baumannii, Wohlfahrtiimonas chitiniclastica
Geographic Location: China, Lebanon
Papers: 3
Databases: Reslit

Papers3

Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient.

PMID 22524407 · 2012

The study identifies the tet(W) gene on plasmid pJA144188 as a novel tetracycline resistance determinant in Corynebacterium resistens DSM 45100, which confers resistance to tetracycline, doxycycline, and minocycline when expressed in Corynebacterium glutamicum.

Gene Information

Gene Name: aacA1
Allele: aacA1
Encodes: aminoglycoside 6'-acetyltransferase
Source Database: Reslit
Confers Resistance To: KanamycinAmikacinNetilmicinSisomicinTobramycin
Organisms Tested In: • Corynebacterium resistens DSM 45100
• Corynebacterium glutamicum ATCC 13032
Validation Method: cloning in E. coli DH5αMCR and antimicrobial susceptibility assays
Sequence Accession: NC_013723|NC_013724|CP018345|CP002857|FN825254

Analysis of pCl107 a large plasmid carried by an ST25 Acinetobacter baumannii strain reveals a complex evolutionary history and links to multiple antibiotic resistance and metabolic pathways.

PMID 37332503 · 2022

The study identifies several antibiotic resistance genes in the plasmid pCl107 of an ST25 Acinetobacter baumannii strain, including aacA1, aacC2, strAB, sul2, and tetA(B), which confer resistance to aminoglycosides, sulfamethoxazole, and tetracycline.

Gene Information

Gene Name: aacA1
Allele: aacA1
Encodes: aminoglycoside adenylyltransferase
Source Database: Reslit
Confers Resistance To: GentamicinAmikacinTobramycin
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Lebanon
Validation Method: gene characterization in pllamid pCl107
Sequence Accession: CP098522

A Wohlfahrtiimonas chitiniclastica with a novel type of bla(VEB-1)-carrying plasmid isolated from a zebra in China.

PMID 38029080 · 2023

The study reports the first genetic characterization of a novel blaVEB-1-carrying plasmid in Wohlfahrtiimonas chitiniclastica, which contains resistance genes blaVEB-1, aadB, aacA1, and tetA(H).

Gene Information

Gene Name: aacA1
Allele: aacA1
Encodes: aminoglycoside acetyltransferase
Source Database: Reslit
Confers Resistance To: Gentamicin
Organisms Tested In: • Wohlfahrtiimonas chitiniclastica
Geographic Location: China
Validation Method: genomic sequencing and resistance gene identification
Sequence Accession: CP115969|CP115970

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aacA1

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