aaca4
aminoglycoside acetyltransferase
Overview
- Mechanism
- acetylation of aminoglycosides
- Validation Method
- decreased susceptibility to aminoglycosides
- Drug Classes
- aminoglycosides, gentamicin, kanamycin, tobramycin, amikacin, netilmicin
- Organisms
- Escherichia coli, Staphylococcus aureus, Pseudomonas fluorescens, Salmonella enterica serovar Typhimurium DT104, Acinetobacter baumannii
- Geographic Location
- Argentina, France, Italy, Japan
- Alleles
- 2
- Papers
- 5
- Databases
- Reslit
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| aacA4 | Reslit | 4 | aminoglycosides, gentamicin +3 | Escherichia coli +3 | Japan, Italy, Argentina | 1999, 2001, 2003, 2004 | AJ223604 | - |
| aacA-aphD | Reslit | 1 | gentamicin, kanamycin | Staphylococcus aureus | France | 2000 | - | - |
Structure of In31, a blaIMP-containing Pseudomonas aeruginosa integron phyletically related to In5, which carries an unusual array of gene cassettes.
The study characterizes the blaIMP gene, which encodes the IMP-1 metallo-beta-lactamase, and identifies several other resistance genes including aacA4, catB6, and qacG, all of which were experimentally validated for their roles in antimicrobial resistance.
Gene Information
- Gene Name
- aaca4
- Allele
- aacA4
- Encodes
- aminoglycoside acetyltransferase
- Source Database
- Reslit
- Confers Resistance To
- aminoglycosides
- Organisms Tested In
- • Escherichia coli
- Geographic Location
- Japan
- Validation Method
- decreased susceptibility to aminoglycosides
- Sequence Accession
- AJ223604
Phenotypic and molecular typing of nosocomial methicillin-resistant Staphylococcus aureus strains susceptible to gentamicin isolated in france from 1995 to 1997.
The study identifies the aacA-aphD gene as a key factor in gentamicin resistance in methicillin-resistant Staphylococcus aureus (MRSA) strains, distinguishing resistant (Gm r) from susceptible (Gm s) strains.
Gene Information
- Gene Name
- aaca4
- Allele
- aacA-aphD
- Encodes
- bifunctional enzyme, AAC6′-APH2"
- Source Database
- Reslit
- Confers Resistance To
- gentamicinkanamycin
- Organisms Tested In
- • Staphylococcus aureus
- Geographic Location
- France
- Validation Method
- hybridization with aacA-aphD probe
In70 of plasmid pAX22, a bla(VIM-1)-containing integron carrying a new aminoglycoside phosphotransferase gene cassette.
CuratedThe study identifies a new integron, In70, carrying the bla(VIM-1) gene, which confers resistance to beta-lactams, including carbapenems, and three aminoglycoside resistance genes: aacA4, aphA15, and aadA1.
Gene Information
- Gene Name
- aaca4
- Allele
- aacA4
- Encodes
- aminoglycoside acetyltransferase
- Source Database
- Reslit
- Mechanism
- acetylation of aminoglycosides
- Confers Resistance To
- gentamicintobramycin
- Organisms Tested In
- • Pseudomonas fluorescens• Escherichia coli
- Geographic Location
- Italy
- Validation Method
- sequence analysis and comparison
- Sequence Accession
- AJ278514|AJ278515
Molecular epidemiology of orf513-bearing class 1 integrons in multiresistant clinical isolates from Argentinean hospitals.
The study identifies the dfrA3b gene, bla CTX-M-2, aacA4, bla OXA-2, and orf513 as significant AMR genes in multidrug-resistant clinical isolates from Argentinean hospitals.
Gene Information
- Gene Name
- aaca4
- Allele
- aacA4
- Encodes
- aminoglycoside acetyltransferase
- Source Database
- Reslit
- Confers Resistance To
- gentamicin
- Organisms Tested In
- • Escherichia coli• Salmonella enterica serovar Typhimurium DT104
- Geographic Location
- Argentina
- Validation Method
- PCR and sequencing
- Sequence Accession
- AY162283
Molecular epidemiology of sequential outbreaks of Acinetobacter baumannii in an intensive care unit shows the emergence of carbapenem resistance.
The study identifies several AMR genes, including aacC1, aadA1a, aacA4, blaOXA-20, and blaIMP, which confer resistance to various antibiotics in carbapenem-resistant Acinetobacter baumannii strains.
Gene Information
- Gene Name
- aaca4
- Allele
- aacA4
- Encodes
- AAC(6')-Ib aminoglycoside acetyltransferase
- Source Database
- Reslit
- Mechanism
- acetylation
- Confers Resistance To
- amikacinnetilmicintobramycin
- Organisms Tested In
- • Acinetobacter baumannii
- Geographic Location
- Italy
- Validation Method
- gene characterization
- Sequence Accession
- AY307113|AY307114
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