Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
aminoglycoside resistance
Overview
Identification and characterization of bacterial pathogens causing bloodstream infections by DNA microarray.
The study identifies and characterizes bacterial pathogens causing bloodstream infections using a DNA microarray. It highlights the presence of resistance genes such as mecA, blaZ, ermA, aacA-aphD, blaTEM-106, and aacC2, which confer resistance to various antibiotics.
Complete nucleotide sequence of pK245, a 98-kilobase plasmid conferring quinolone resistance and extended-spectrum-beta-lactamase activity in a clinical Klebsiella pneumoniae isolate.
The study identifies the plasmid pK245 carrying the qnrS quinolone resistance gene and the blaSHV-2 extended-spectrum beta-lactamase gene, along with other resistance genes such as aacC2, strA, strB, catA2, sul2, tetD, and dfrA14, which confer resistance to multiple antimicrobial classes in Klebsiella pneumoniae.
Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center.
The study identified multiple antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates, including bla ADC, bla OXA-69-like, bla OXA-23-like, bla OXA-58-like, bla TEM, bla PER, aacC1, aacC2, aadA1, aadB, and aphA6, which confer resistance to various antibiotics such as ceftazidime, cefepime, imipenem, meropenem, ampicillin, ampicillin-sulbactam, gentamicin, tobramycin, streptomycin, spectinomycin, amikacin, kanamycin, and neomycin.
Complete nucleotide sequence of the pCTX-M3 plasmid and its involvement in spread of the extended-spectrum beta-lactamase gene blaCTX-M-3.
The study characterizes the pCTX-M3 plasmid, which carries the blaCTX-M-3 gene, a extended-spectrum beta-lactamase, along with other resistance genes such as blaTEM-1, aadA2, aacC2, armA, dfrA12, and sul1, contributing to resistance against beta-lactams, aminoglycosides, and sulfonamides.
Genetic identity of aminoglycoside-resistance genes in Escherichia coli isolates from human and animal sources.
The study identified the aacC2 gene as a major contributor to gentamicin resistance in Escherichia coli isolates from both human and animal sources.
Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong.
The study reports the complete sequencing of the plasmid pNDM-HK, which encodes the NDM-1 carbapenemase. The plasmid contains multiple resistance genes, including blaNDM-1, aacC2, armA, and blaTEM-1, contributing to resistance against carbapenems, aminoglycosides, and beta-lactams.
Acinetobacter baumannii isolates from pets and horses in Switzerland: molecular characterization and clinical data.
The study identified several AMR genes and mutations in Acinetobacter baumannii isolates from pets and horses in Switzerland, including blaOXA-66, blaADC-25, blaTEM-1, aacC2, aadA1, aacC1, IS1133, ISAb1, and mutations in gyrA and parC genes associated with resistance to carbapenems, cephalosporins, piperacillin/tazobactam, gentamicin, and ciprofloxacin.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.
Characterization of an IncFII plasmid encoding NDM-1 from Escherichia coli ST131.
The study characterizes an IncFII plasmid carrying the blaNDM-1 gene, along with other resistance genes such as aacA4, aadA2, aacC2, and blaOXA-1, which contribute to multidrug resistance in E. coli ST131.
Characterization of multi-antibiotic-resistant Escherichia coli Isolated from beef cattle in Japan.
The study identified multiple AMR genes in E. coli isolates from beef cattle in Japan, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Infections caused by fluoroquinolone-resistant Escherichia coli following transrectal ultrasound-guided biopsy of the prostate.
The study identified fluoroquinolone-resistant Escherichia coli isolates with mutations in gyrA and parC genes, as well as aac(6')-Ib-cr, aacC1, aadA1, aadB, and aacC2 genes associated with gentamicin resistance.
Nucleotide sequence of the aacC2 gene, a gentamicin resistance determinant involved in a hospital epidemic of multiply resistant members of the family Enterobacteriaceae.
The aacC2 gene was identified as a gentamicin resistance determinant in Enterobacter cloacae, encoding an aminoglycoside-(3)-N-acetyltransferase that confers resistance to gentamicin.
Resistance phenotypes and genotypes among multiple-antimicrobial-resistant Salmonella enterica subspecies enterica serovar Choleraesuis strains isolated between 2008 and 2012 from slaughter pigs in Okinawa Prefecture, Japan.
The study identified multiple antimicrobial resistance genes in Salmonella enterica subspecies enterica serovar Choleraesuis strains, including blaTEM, strA, strB, aadA1, aadA2, aphA1, aacC2, tetB, sul1, sul2, dhfrXII, and dhfrXIII. Additionally, mutations in the QRDRs of gyrA and parC were associated with quinolone resistance.
Antimicrobial resistance of Escherichia coli isolates from canine urinary tract infections.
The study identified bla TEM-1, tet(B), tet(A), cmlA, floR, and aacC2 as key antimicrobial resistance genes in E. coli isolates from canine urinary tract infections, along with mutations in gyrA and parC conferring fluoroquinolone resistance.
Novel Aminoglycoside Resistance Transposons and Transposon-Derived Circular Forms Detected in Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates.
The study identified various aminoglycoside resistance genes and novel transposons, including Tn6279, ΔTn6279, and Tn1548-like structures, contributing to the resistance of carbapenem-resistant Acinetobacter baumannii isolates.
Frequency, Antimicrobial Resistance and Genetic Diversity of Klebsiella pneumoniae in Food Samples.
The study identified various AMR genes and mutations in K. pneumoniae isolates from food samples, including beta-lactamases (blaSHV, blaCTX-M-1, blaCTX-M-10), folate pathway inhibitor gene (dhfr), quinolone resistance genes (qnrB, qnrA, qnrS, aac(6')-Ib-cr), aminoglycoside resistance genes (aacA4, aacC2, aadA1), and mutations in gyrA and parC genes associated with fluoroquinolone resistance.
Genomic characterization of novel IncFII-type multidrug resistant plasmids p0716-KPC and p12181-KPC from Klebsiella pneumoniae.
The study characterizes two novel IncFII-type multidrug-resistant plasmids, p0716-KPC and p12181-KPC, from Klebsiella pneumoniae. These plasmids carry multiple resistance genes, including blaKPC-2, mph(A), strAB, aacC2, qacEΔ1, sul1, sul2, dfrA25, aphA1a, and blaTEM-1, contributing to resistance against various antibiotics.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
First Report of Coexistence of Three Different MDR Plasmids, and That of Occurrence of IMP-Encoding Plasmid in Leclercia adecarboxylata.
The study reports the first identification of three different multidrug-resistant (MDR) plasmids in a single clinical isolate of Leclercia adecarboxylata, including the blaIMP-8 gene encoded on an IMP-encoding plasmid. These plasmids harbor various AMR genes such as blaIMP-8, aacC2, aadA2, mph(A), sul1, qacED1, mer, chrA, dfrA12, tmrB, catA1, catB8, tet(C), blaCTX-M-9, and blaTEM-1.
Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors.
The study identified several antimicrobial resistance genes (ARGs) in the gut of young children in urban Maputo, Mozambique, including aadA1, SHV, ermA, ermB, mefA, tetA, tetB, and others, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, macrolides, tetracyclines, and fluoroquinolones.
Phenotypic and molecular characterization of antimicrobial resistant Escherichia coli from urinary tract infections in Port-Harcourt, Nigeria.
The study identified multiple antimicrobial resistance genes in E. coli isolates from urinary tract infections in Port-Harcourt, Nigeria, including blaTEM, blaCTX-M-15, blaSHV, blaOXA-1, blaCMY-2, qnrD, qnrS, aac(6')-Ib, and aacC2. These genes were associated with resistance to various antibiotics, highlighting the complexity of multidrug resistance in these isolates.
Structural Genomics of repA, repB 1-Carrying IncFIB Family pA1705-qnrS, P911021-tetA, and P1642-tetA, Multidrug-Resistant Plasmids from Klebsiella pneumoniae.
The study characterizes multidrug-resistant plasmids pA1705-qnrS, p911021-tetA, and p1642-tetA from Klebsiella pneumoniae, identifying several AMR genes including beta-lactamases (bla CTX-M-14, bla TEM-1, bla OXA-1, bla SHV-12, bla CTX-M-15, bla CTX-M-65), quinolone resistance gene qnrS1, tetracycline resistance genes tetA (A) and tetA (D), aminoglycoside resistance genes aacA4cr and aacC2, streptomycin resistance genes strA and strB, dihydrofolate reductase genes dfrA1 and dfrA14, sulfonamide resistance gene sul2, macrolide resistance gene mph (A), efflux pump gene oqxAB, chloramphenicol acetyltransferase gene catB3, and tunicamycin resistance gene tmrB.
Role of aminoglycoside-modifying enzymes and 16S rRNA methylase (ArmA) in resistance of Acinetobacter baumannii clinical isolates against aminoglycosides.
The study identified several aminoglycoside resistance genes, including aphA6, aadB, aadA1, aacA4, aacC2, and ArmA, which contribute to high levels of resistance against various aminoglycosides in Acinetobacter baumannii clinical isolates.
Limited and Strain-Specific Transcriptional and Growth Responses to Acquisition of a Multidrug Resistance Plasmid in Genetically Diverse Escherichia coli Lineages.
The study identified the ESBL plasmid pLL35 carrying blaCTX-M-15, TEM-112, and OXA-9, which conferred varying levels of cefotaxime resistance across different E. coli strains. The transcriptional response to plasmid acquisition was limited and strain-specific, with minimal global changes in gene expression.
Public health implications of plasmid-mediated quinolone and aminoglycoside resistance genes in Escherichia coli inhabiting a major anthropogenic river of India.
The study identified plasmid-mediated quinolone resistance gene qnrS1 and aminoglycoside resistance genes strA-strB, aphA1, and aacC2 in E. coli isolates from a major Indian river. These genes were found to be located on conjugative plasmids, highlighting their potential for horizontal gene transfer.
Analysis of Salmonella enterica Isolated from a Mixed-Use Watershed in Georgia, USA: Antimicrobial Resistance, Serotype Diversity, and Genetic Relatedness to Human Isolates.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from a mixed-use watershed in Georgia, USA, including bla CMY-2, aadA2, strA, strB, sul1, sul2, tetA, tetC, floR, and dfrA12, which conferred resistance to various antibiotics such as ceftiofur, ceftriaxone, streptomycin, sulfisoxazole, tetracycline, chloramphenicol, and trimethoprim.
Antibiotic resistance genes of public health importance in livestock and humans in an informal urban community in Nepal.
The study identified several antibiotic resistance genes, including bla SHV-1, QnrS, ermC, tetA, tetB, aacC2, and aadA1, in various sources such as humans, animals, and water in an urban informal settlement in Nepal.
Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes.
The study identifies various AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Chile, including blaTEM, aacC2, aphA6, sul1, sul2, catA1, tetA(A), aadA1, dfrA1, strAB, cmlB1, floR, oxa58, and oxa23, highlighting the diversity of resistance mechanisms and the role of mobile genetic elements in their dissemination.
Antimicrobial Resistance, Virulence Profiles, and Public Health Significance of Enterococcus faecalis Isolated from Clinical Mastitis of Cattle in Bangladesh.
The study identified tetracycline resistance genes tetK, tetL, and tetM, as well as aminoglycoside resistance genes aacC2, aacC4, and aph(3'')-IIIa, and the vancomycin resistance gene vanB in Enterococcus faecalis isolates from bovine clinical mastitis in Bangladesh.
Incidence of antibiotic resistance genotypes of Vibrio species recovered from selected freshwaters in Southwest Nigeria.
The study identified multiple antibiotic resistance genes in Vibrio species from freshwater samples in Southwest Nigeria, including sulI, sulII, ampC, blaOXA, blaPSE, tetA, tetE, strA, aacC2, and aphA1, highlighting the environmental spread of resistance genes.
Analysis of pCl107 a large plasmid carried by an ST25 Acinetobacter baumannii strain reveals a complex evolutionary history and links to multiple antibiotic resistance and metabolic pathways.
The study identifies several antibiotic resistance genes in the plasmid pCl107 of an ST25 Acinetobacter baumannii strain, including aacA1, aacC2, strAB, sul2, and tetA(B), which confer resistance to aminoglycosides, sulfamethoxazole, and tetracycline.
ARGs Detection in Listeria Monocytogenes Strains Isolated from the Atlantic Salmon (Salmo salar) Food Industry: A Retrospective Study.
The study identified various AMR genes in L. monocytogenes strains from Atlantic salmon, including tetracycline resistance genes (tetC, tetD, tetK, tetL, tetS), aminoglycoside resistance genes (aadA, strA, aacC2, aphA1, aphA2), macrolide resistance genes (cmlA1, catI, catII), and oxazolidinone resistance genes (cfr, optrA, poxtA).
Polymorphism and mutational diversity of virulence (vcgCPI/vcgCPE) and resistance determinants (aac(3)-IIa, (aacC2, strA, Sul 1, and 11) among human pathogenic Vibrio species recovered from surface waters in South-Western districts of Uganda.
The study identified various nucleotide variations in virulence determinants of V. vulnificus (vcgCPI) and resistance genes (strA, aadA, aac(3)-IIa, aacC2, sul1, and sul11) among Vibrio isolates.
Comparative genomics of Tn6411 transposons carrying the blaIMP-1 gene in Pseudomonas aeruginosa.
The study identifies the presence of the blaIMP-1 gene within the Tn6411 transposon in Pseudomonas aeruginosa strains, along with aacC2 and catB7, contributing to resistance against carbapenems, aminoglycosides, and chloramphenicol.
IncC plasmid genome rearrangements influence the vertical and horizontal transmission tradeoff in Escherichia coli.
The study identifies blaCTX-M-14 and blaCTX-M-15 as beta-lactamase genes, aacC2, aph, and sul2 as aminoglycoside and sulfonamide resistance genes, and shows that plasmid rearrangements enhance conjugation efficiency without affecting vertical transmission.
Antibiotic resistance in white stork cloaca and environmental samples
The study identified various antibiotic resistance genes in bacterial isolates from white stork cloaca and environmental samples, highlighting the presence of resistance mechanisms against beta-lactams, aminoglycosides, quinolones, and polymyxins.
Prevalence and Genetic Characterization of Antimicrobial-resistant Escherichia coli from Wild Boar Meat in Japan.
The study identified antimicrobial-resistant Escherichia coli in wild boar meat in Japan, with resistance genes including blaTEM, strA, strB, aacC2, aphA1, tetA, and tetB.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
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