aacc4

aminoglycoside acetyltransferase

Validation StatusCandidate

Overview

Mechanism: acetylation
Validation Method: cloning and overexpression, kinetic studies
Drug Classes: aminoglycosides
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

The kinetic mechanism of AAC(3)-IV aminoglycoside acetyltransferase from Escherichia coli.

PMID 16331988 · 2005

The study characterizes the aminoglycoside acetyltransferase AAC(3)-IV from Escherichia coli, which confers resistance to a broad range of aminoglycosides, including apramycin.

Gene Information

Gene Name: aacc4
Allele: aacC4
Encodes: aminoglycoside acetyltransferase
Source Database: Reslit
Mechanism: acetylation
Confers Resistance To: aminoglycosides
Organisms Tested In: • Escherichia coli
Validation Method: cloning and overexpression, kinetic studies
Sequence Accession: DQ241380

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aacc4

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