Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
adenyltransferase
Overview
Rapid Screening Technique for Class 1 Integrons in Enterobacteriaceae and Nonfermenting Gram-Negative Bacteria and Its Use in Molecular Epidemiology.
The study identifies aadA and dhfr gene cassettes within class 1 integrons as major contributors to antimicrobial resistance in Enterobacteriaceae and nonfermenting gram-negative bacteria.
Identification and characterization of integron-mediated antibiotic resistance among Shiga toxin-producing Escherichia coli isolates.
The study identifies class 1 integrons in Shiga toxin-producing Escherichia coli (STEC) isolates, including the aadA, aadA1, aadA2, and dfrXII genes, which confer resistance to streptomycin, spectinomycin, and trimethoprim.
Chromosomal gene inactivation in the green sulfur bacterium Chlorobium tepidum by natural transformation.
The study describes the successful inactivation of the nifD gene in Chlorobium tepidum using natural transformation and homologous recombination, utilizing antibiotic resistance markers including aacC1, aadA, and ermC-cat.
aadA Confers Streptomycin Resistance in Borrelia burgdorferi.
The aadA gene, which encodes an aminoglycoside-3''-adenylyltransferase, confers resistance to spectinomycin and streptomycin in Borrelia burgdorferi and Escherichia coli.
Integrons and gene cassettes in clinical isolates of co-trimoxazole-resistant Gram-negative bacteria.
The study identified a new dfr gene, dfrA22, in a class 1 integron, which contributes to trimethoprim resistance in co-trimoxazole-resistant Gram-negative bacteria.
Impact of feed supplementation with antimicrobial agents on growth performance of broiler chickens, Clostridium perfringens and enterococcus counts, and antibiotic resistance phenotypes and distribution of antimicrobial resistance determinants in Escherichia coli isolates.
The study identified several AMR genes in E. coli isolates from broiler chickens, including blaTEM, blaSHV, aadA, tet(A), tet(B), sulI, sulII, and floR, which conferred resistance to various antibiotics such as amoxicillin, tetracycline, sulfonamides, and chloramphenicol.
Diagnostic accuracy of class 1 integron PCR method in detection of antibiotic resistance in Salmonella isolates from swine production systems.
The study identified aadA, aadB, and bla genes in class 1 integrons of Salmonella isolates, which conferred resistance to streptomycin, spectinomycin, gentamicin, kanamycin, and ampicillin.
Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5
The study identifies multiple AMR genes and mutations in the multidrug-resistant E. coli isolate SMS-3-5, including beta-lactamase blaT, aminoglycoside resistance genes aadA and aph, sulfonamide resistance gene sul2, trimethoprim resistance gene dhfrV, chloramphenicol resistance gene cmlA, tetracycline resistance gene tetRA, and quinolone resistance mutations in gyrA and parC.
Antimicrobial resistances do not affect colonization parameters of intestinal E. coli in a small piglet group.
The study identified various AMR genes in commensal E. coli from pigs, including blaTEM, catA1, aph(3')-Ia, aadA, strA/strB, tet(A), tet(B), sul1, sul2, and sul3. These genes conferred resistance to antibiotics such as ampicillin, chloramphenicol, kanamycin, neomycin, streptomycin, spectinomycin, tetracycline, and sulfamethoxazole. However, the presence of these resistance genes did not provide a significant colonization advantage or disadvantage in the pig intestine.
Transformation of Anaplasma marginale.
The study successfully transformed Anaplasma marginale with a plasmid carrying the TurboGFP gene and the aadA gene, which confers resistance to spectinomycin and streptomycin.
Antimicrobial resistance, virulence-associated genes, and pulsed-field gel electrophoresis profiles of Salmonella enterica subsp. enterica serovar Typhimurium isolated from piglets with diarrhea in Korea.
The study identified multiple antimicrobial resistance genes in Salmonella enterica subsp. enterica serovar Typhimurium isolates from piglets with diarrhea in Korea, including bla PSE, bla TEM, cat1, cat2, floR, strA, strB, aadA, sulI, sulII, tetA, tetC, and tetG.
Characterization of multidrug-resistant Escherichia coli isolates from animals presenting at a university veterinary hospital.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from animals, including bla TEM, bla CTX-M-2, bla CMY-2, strA-strB, aadA, aphA1, aadB, cat, floR, sul1, sul2, tet(A), and tet(B). These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Molecular characterization of multidrug-resistant Escherichia coli isolates from Irish cattle farms.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from Irish cattle farms, including strA-strB, aphA1, aadA, aadB, blaTEM, sul2, tet(A), and tet(B). These genes were associated with resistance to streptomycin, neomycin, kanamycin, spectinomycin, ampicillin, amoxicillin-clavulanic acid, sulfonamides, and tetracycline.
Partial Genome Assembly for a Candidate Division OP11 Single Cell from an Anoxic Spring (Zodletone Spring, Oklahoma).
The study identifies a beta-lactamase (blaA) and an aminoglycoside adenyltransferase (aadA) in the OP11 single cell genome, indicating resistance to beta-lactam and aminoglycoside antibiotics.
Transcriptome mapping of pAR060302, a blaCMY-2-positive broad-host-range IncA/C plasmid.
The study characterizes the transcriptome of pAR060302, a blaCMY-2-positive IncA/C plasmid, highlighting the transcription of resistance genes such as blaCMY-2, aadA, aacA, and floR, which confer resistance to extended-spectrum cephalosporins, aminoglycosides, and phenicols, respectively.
Enhanced antibiotic multi-resistance in nasal and faecal bacteria after agricultural use of streptomycin.
The study found that agricultural use of streptomycin leads to increased multidrug resistance in nasal and faecal bacteria, including streptomycin resistance genes strA, strB, aadA, and class 1 integron intI1.
DNA sequence analysis of plasmids from multidrug resistant Salmonella enterica serotype Heidelberg isolates.
The study identified multiple antimicrobial resistance genes in plasmids from multidrug-resistant Salmonella enterica serotype Heidelberg isolates, including bla CMY, aadA, aadB, aphA, strA, strB, sul1, sul2, tetA, floR, cmlA, dfrA1, dfrA12, and aacC.
Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis.
The study identified tetracycline resistance genes tet(M) and tet(O), the erythromycin resistance gene erm(B), and the streptomycin resistance gene aadA in Streptococcus canis isolates, highlighting the presence of antimicrobial resistance mechanisms in this species.
Characterization of class 1 integrons and antibiotic resistance genes in multidrug-resistant Salmonella enterica isolates from foodstuff and related sources.
The study identified several AMR genes, including aadA, sul1, sul2, tetA, blaTEM-1, and qacEAI, associated with resistance to streptomycin, sulfamethoxazole-trimethoprim, tetracycline, ampicillin, and quaternary ammonium compounds, respectively. A mutation in the gyrA gene (Ser83Phe) was linked to resistance to nalidixic acid and enrofloxacin.
Characterization of microbiota composition and presence of selected antibiotic resistance genes in carriage water of ornamental fish.
The study identified several antibiotic resistance genes including sul1, tet(A), strA, aadA, cat, tet(G), and sul2 in the microbiota of ornamental fish carriage water. These genes were found to be prevalent and associated with various bacterial families.
Prevalence and antibiogram profiling of Escherichia coli pathotypes isolated from the Kat River and the Fort Beaufort abstraction water.
The study identified the presence of antibiotic resistance genes aadA, tetA, and bla in E. coli isolates from the Kat River and Fort Beaufort abstraction water, indicating resistance to streptomycin, tetracycline, and beta-lactam antibiotics.
Chloroplast-expressed MSI-99 in tobacco improves disease resistance and displays inhibitory effect against rice blast fungus.
The study demonstrates that chloroplast-expressed MSI-99 enhances disease resistance in tobacco and shows inhibitory effects against rice blast fungus. The aadA gene, which confers resistance to spectinomycin, was validated in the study.
Insight into the mobilome of Aeromonas strains.
The study characterizes various antibiotic resistance genes (ARG) in Aeromonas strains, highlighting the presence of beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others. These genes are often located on plasmids and contribute to multidrug resistance.
Abundance of Antibiotic Resistance Genes in Bacteriophage following Soil Fertilization with Dairy Manure or Municipal Biosolids, and Evidence for Potential Transduction.
The study identified antibiotic resistance genes (ARGs) in bacteriophage and bacterial fractions of agricultural soil, demonstrating that soilborne bacteriophage represents a reservoir of antibiotic resistance and that bacteriophage could play a significant role in the horizontal transfer of resistance genes in agricultural soil microbiomes.
Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase.
The study characterizes the structure and function of AadA, an aminoglycoside (3'')(9) adenyltransferase from Salmonella enterica, which confers resistance to streptomycin and spectinomycin through enzymatic modification.
Identification and antimicrobial resistance prevalence of pathogenic Escherichia coli strains from treated wastewater effluents in Eastern Cape, South Africa.
The study identified several AMR genes in E. coli isolates from wastewater effluents, including strA, aadA, catI, cmlA1, blaTEM, and various tetracycline resistance genes (tetA, tetB, tetC, tetD, tetK, tetM). These genes conferred resistance to multiple antibiotics such as streptomycin, gentamicin, chloramphenicol, ampicillin, and tetracycline.
Antibiotic Resistance, Core-Genome and Protein Expression in IncHI1 Plasmids in Salmonella Typhimurium.
The study identified multiple antibiotic resistance genes in IncHI1 plasmids of Salmonella Typhimurium, including tet(B), tet(A), blaTEM, strA, strB, sul2, aadA, dfrA, catA1, aphA1a, and aad(3)IId, which confer resistance to various antibiotics such as tetracycline, beta-lactam, streptomycin, sulfonamide, aminoglycoside, chloramphenicol, and trimethoprim.
Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION(TM) sequencing.
The study presents a real-time analysis framework for MinION sequencing data, demonstrating the ability to identify pathogens and antibiotic resistance genes within a few hours of sequencing. Key resistance genes identified include blaSHV, mphA, strA, strB, blaTEM, sul2, blaOXA, aac3, aac6, blaCMY, blaCFE, blaLAT, blaBIL, QnrB, aadA, oqxA, tetA, oqxB, rmtC, sul1, sul3, fosA, blaNDM, oqxA, blaSHV, oqxB, aadB, sul1, sul3, blaOXA, blaOKP, fosA, blaSHV, blaOKP, blaLEN, oqxA, and oqxB.
Versatile nourseothricin and streptomycin/spectinomycin resistance gene cassettes and their use in chromosome integration vectors.
The study describes the development of versatile cassettes containing nourseothricin, streptomycin/spectinomycin, and spectinomycin resistance genes (nat, aadA, aad9) for genetic manipulation of bacteria. These cassettes enable the creation of single-copy insertion vectors and are effective in selecting for genetic elements in AmrAB-OprA efflux pump mutants of Burkholderia species.
Determination of antibiotic resistance genes in relation to phylogenetic background in Escherichia coli isolates from fecal samples of healthy pet cats in Kerman city.
The study identified several antibiotic resistance genes in E. coli isolates from healthy pet cats, including tetB, tetA, aadA, sulI, qnrS, and dhfrV, with varying prevalence rates. These genes were associated with resistance to tetracycline, aminoglycosides, sulfonamides, fluoroquinolones, and trimethoprim.
Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland.
The study identifies several AMR genes and mutations associated with multidrug-resistant Klebsiella pneumoniae in the UK and Ireland, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and mutations in gyrB contributing to fluoroquinolone resistance.
Whole-Genome Sequencing of Drug-Resistant Salmonella enterica Isolates from Dairy Cattle and Humans in New York and Washington States Reveals Source and Geographic Associations.
The study identified several AMR genes and mutations in Salmonella enterica isolates from dairy cattle and humans in New York and Washington States, highlighting the role of geographic and source-specific factors in AMR dissemination.
A genetic system for targeted mutations to disrupt and restore genes in the obligate bacterium, Ehrlichia chaffeensis.
The study describes a genetic system for targeted mutations in Ehrlichia chaffeensis, demonstrating the disruption and restoration of two genes, Ech_0230 and Ech_0379, using homologous recombination. The aadA gene was utilized to confer resistance to spectinomycin and streptomycin.
ARIBA: Rapid identification of antimicrobial resistance genes and variants from whole-genome sequencing data
The paper presents ARIBA, a tool for identifying antimicrobial resistance genes and mutations from sequencing data. It evaluates the performance of ARIBA on three datasets, demonstrating its accuracy and efficiency in detecting resistance genes and mutations in Enterococcus faecium, Shigella sonnei, and Neisseria gonorrhoeae.
Molecular analysis of multidrug resistance in clinical isolates of Shigella spp. from 2001-2010 in Kolkata, India: role of integrons, plasmids, and topoisomerase mutations.
The study identified several AMR genes including dfrV, dfrA1, aadA, blaOXA, sat, InsE, and InsO, as well as mutations in gyrA and parC contributing to quinolone resistance in Shigella isolates.
Evolution of high-level resistance during low-level antibiotic exposure.
High-level streptomycin resistance in Salmonella enterica evolved through combinations of five mutations: gidB, trkH, nuoG, cyoB, and znuA, along with the aadA gene. These mutations collectively enhance resistance through altered ribosomal targets, reduced drug uptake, and enzymatic modification.
Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica.
AadA from Salmonella enterica is a dual-specificity aminoglycoside adenylyltransferase that confers resistance to streptomycin and spectinomycin. Mutations in the catalytic residue Glu-87 significantly reduce its activity.
A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains.
The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.
Antimicrobial Resistance in Escherichia coli.
The paper discusses the characterization of various antimicrobial resistance genes in Escherichia coli, including extended-spectrum beta-lactamases (ESBLs), AmpC cephalosporinases, carbapenemases, plasmid-mediated quinolone resistance (PMQR) genes, aminoglycoside-modifying enzymes, fosfomycin resistance genes, and tetracycline resistance genes. These genes confer resistance to multiple classes of antibiotics, highlighting the complex nature of antimicrobial resistance in E. coli.
Spread and Persistence of Virulence and Antibiotic Resistance Genes: A Ride on the F Plasmid Conjugation Module.
The paper reviews the role of F-like plasmids in the spread and persistence of antibiotic resistance and virulence genes, highlighting the importance of these plasmids in the dissemination of resistance genes such as blaTEM-1, sul1, aadA, and catA1, as well as virulence factors like ompP and colicin genes.
Safety and Growth Optimization of Lactic Acid Bacteria Isolated From Feedlot Cattle for Probiotic Formula Design.
The study identified several AMR genes in feedlot lactobacilli, including ermB, tet(S), aadA, ant(6), bla, and aph(3''-III), which confer resistance to erythromycin, tetracycline, streptomycin, kanamycin, and ampicillin. These genes were detected through PCR analysis and correlate with phenotypic resistance in some strains.
Genotypic and phenotypic characterization of Salmonella enterica subsp. enterica serovar Typhimurium monophasic variants isolated in Thailand and Japan.
The study identified several antimicrobial resistance genes in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variants, including blaTEM, aadA, strA, strB, tet(A), tet(B), tet(G), sul1, sul2, sul3, and floR, which confer resistance to ampicillin, streptomycin, oxytetracycline, sulfisoxazole, and chloramphenicol.
Analysis of bacteriological pollution and the detection of antibiotic resistance genes of prevailing bacteria emanating from pig farm seepage.
The study identified several antibiotic resistance genes in bacteria isolated from pig farm seepage, including aadA, aa(6')-le-aph(2")-la, aph(2")-lb, aph(2")-lc, aph(2")-ld, aph(3")-llla, ant(4')-la, VanA, VanB, VanC2/C3, InuA, InuB, InuC, InuF, blaTEM, blaSHV, blaOXA, OtrA, OtrB, Sul1, and Sul2. These genes conferred resistance to various antibiotics such as penicillins, sulfamethoxazole, tetracyclines, and glycopeptides.
Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz, Bolivia.
The study identified multidrug-resistant Enterobacteriaceae in the Choqueyapu River, including E. coli and Enterobacter cloacae carrying bla CTX-M, bla KPC, bla NDM, bla VIM, and bla OXA-48 genes, highlighting the environmental spread of antibiotic resistance.
Manure and Doxycycline Affect the Bacterial Community and Its Resistome in Lettuce Rhizosphere and Bulk Soil.
The study identified the tetracycline resistance gene tetA(P) as being highly enriched in manure-treated soil and rhizosphere, particularly in doxycycline-treated bulk soil, indicating its potential as a marker for soil contamination by antibiotic-resistant bacteria and antibiotics.
Antibiotic Resistance of E. coli Isolated From a Constructed Wetland Dominated by a Crow Roost, With Emphasis on ESBL and AmpC Containing E. coli.
The study identified bla ctx-M and bla cmy-2 genes as major contributors to extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase resistance in E. coli isolates from a constructed wetland dominated by a crow roost. Tetracycline resistance was primarily mediated by tet (A), tet (B), and tet (M), while streptomycin resistance was linked to strA, strB, and aadA. Sulfamethoxazole/trimethoprim resistance was associated with the sul1 gene.
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.
Bogotá River anthropogenic contamination alters microbial communities and promotes spread of antibiotic resistance genes.
The study identifies multiple antibiotic resistance genes (ARGs) in water samples from the Bogotá River and hospital wastewaters, indicating the spread of resistance due to anthropogenic contamination.
Longitudinal Shedding Patterns and Characterization of Antibiotic Resistant E. coli in Pastured Goats using a Cohort Study.
The study identified tetracycline resistance mediated by tetB, ampicillin resistance via blaTEM, and streptomycin resistance through aadA and strpA/strpB genes in E. coli isolates from pastured goats. Mutations in gyrA conferred resistance to nalidixic acid.
Phylogenetic Diversity, Antimicrobial Susceptibility and Virulence Characteristics of Escherichia coli Isolates from Pigeon Meat.
The study identified several AMR genes in E. coli isolates from pigeon meat, including ampC, aadA, cmlA, sul1, sul2, and sul3, which confer resistance to beta-lactams, aminoglycosides, chloramphenicol, and sulfonamides.
Research Note: Longitudinal monitoring of chicken houses in a commercial layer farm for antimicrobial resistance in Escherichia coli with special reference to plasmid-mediated quinolone resistance.
The study identified qnrS1, qnrS2, and qnrS13 genes as plasmid-mediated quinolone resistance genes in E. coli isolates from a commercial layer farm. Additionally, blaTEM, aadA, tetA, and dfrA1 genes were found to confer resistance to ampicillin, dihydrostreptomycin, oxytetracycline, and trimethoprim, respectively.
Comparative genomic analysis reveals high intra-serovar plasticity within Salmonella Napoli isolated in 2005-2017.
The study identifies acquired antimicrobial resistance genes in Salmonella Napoli, including aadA, bla, tet, and sul, which confer resistance to streptomycin, beta-lactams, tetracyclines, and sulfonamides, respectively.
Putative Protein Biomarkers of Escherichia coli Antibiotic Multiresistance Identified by MALDI Mass Spectrometry.
The study identifies several AMR genes in E. coli isolates, including tet(A), tet(B), blaCTX-M, blaTEM, blaSHV, sul1, sul2, sul3, cmlA, aac(3)-II, aac(3)-IV, aadA, and strA-strB, which confer resistance to tetracycline, ampicillin, cefoxitin, trimethoprim-sulfamethoxazole, chloramphenicol, gentamicin, and streptomycin.
An NDM-1-Producing Acinetobacter towneri Isolate from Hospital Sewage in China.
Functional and structural map of pLST1000: A multiresistance plasmid widely distributed in Enterobacteriaceae.
The study characterizes the multiresistance plasmid pLST1000, identifying several AMR genes including aadB, aadA, bla-TEM, bla-OXA2, sul, and mer, which confer resistance to gentamicin, streptomycin, ampicillin, sulfonamide, and mercury, respectively.
Co-occurrence of mcr-1, mcr-3, mcr-7 and clinically relevant antimicrobial resistance genes in environmental and fecal samples.
The study identified the co-occurrence of mcr-1, mcr-3, mcr-7.1, and various clinically relevant antimicrobial resistance genes in environmental and fecal samples from a Brazilian zoo, highlighting the potential reservoir of these genes in zoological environments.
Prevalence and distribution of antimicrobial resistance determinants of Escherichia coli isolates obtained from meat in South Africa.
The study identified several AMR genes in E. coli isolates from meat in South Africa, including aadA, strA, aph(3)-Ia, aph(3)-IIa, aac(3)-IIa, blaTEM, blaZ, ampC, cat1, cat2, cmlA1, sul1, sul2, tetA, tetB, tetC, tetD, and tetM, which confer resistance to various antibiotics such as streptomycin, kanamycin, neomycin, gentamicin, amoxicillin, ampicillin, chloramphenicol, cotrimoxazole, and tetracycline.
Plasmid Replicon Typing of Antibiotic-Resistant Escherichia coli From Clams and Marine Sediments.
The study identified various antibiotic resistance genes in E. coli isolates from clams and marine sediments, including blaTEM, blaSHV, blaCTX-M, tet(A), dfrA1, aadA, strA, strB, and ant(3"). These genes were associated with resistance to beta-lactams, tetracycline, trimethoprim/sulfamethoxazole, and streptomycin.
Molecular Characterization and Antimicrobial Susceptibilities of Nocardia Species Isolated from the Soil; A Comparison with Species Isolated from Humans.
The study identified various antimicrobial resistance genes in Nocardia species isolated from soil, including beta-lactamase, aminoglycoside modifying enzymes, macrolide resistance genes, chloramphenicol resistance proteins, vancomycin resistance, and multidrug efflux pumps. Some soil N. cyriacigeorgica strains exhibited distinct genetic profiles suggesting possible new subspecies or species.
Antimicrobial Resistance in Swine Fecal Specimens Across Different Farm Management Systems.
The study identified several AMR genes associated with different antimicrobial classes in swine fecal samples from farms with varying antimicrobial usage levels. These genes included beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, macrolide resistance markers, polymyxin resistance genes, phenicol resistance genes, and trimethoprim resistance genes.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.
The study identified various AMR genes and mutations in Pseudomonas spp. isolated from raw milk, highlighting the prevalence of multidrug-resistant strains and the presence of resistance determinants such as beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps.
F Plasmids Are the Major Carriers of Antibiotic Resistance Genes in Human-Associated Commensal Escherichia coli.
The study identifies various antibiotic resistance genes in commensal E. coli isolates, highlighting the prevalence of resistance genes on F plasmids and the role of mobile genetic elements in their dissemination.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Occurrence of Antibiotic-Resistant Bacteria and Genes in Two Drinking Water Treatment and Distribution Systems in the North-West Province of South Africa.
The study identified several antibiotic resistance genes, including strA, strB, aadA, dfrB, bla CTX-M, and tetA, in heterotrophic bacteria from drinking water treatment and distribution systems in South Africa.
Occurrence, identification, and antibiogram signatures of selected Enterobacteriaceae from Tsomo and Tyhume rivers in the Eastern Cape Province, Republic of South Africa.
The study identified various beta-lactamase genes (bla TEM, bla CTX-M, bla SHV, bla OXA-1-like, bla PER, bla VIM, bla IMP, bla KPC, bla GES, bla OXA-48-like), plasmid-mediated AmpC beta-lactamase genes (bla EBC, bla ACC, bla FOX, bla CIT), tetracycline resistance genes (tetA, tetB, tetD, tetM), chloramphenicol resistance gene (catII), and sulfonamide resistance gene (sulII) in Enterobacteriaceae isolates from Tsomo and Tyhume rivers.
Fecal Klebsiella pneumoniae Carriage Is Intermittent and of High Clonal Diversity.
The study identified 25 antibiotic resistance genes in 80 Klebsiella pneumoniae isolates, primarily encoding efflux pumps and inactivating enzymes. Notably, blaSHV, emrB, emrR, marA, marR, msbA, ompK37, oqxA, oqxB, acrA, vgaC, fosA, tet(D), APH(3")-Ib, APH(6)-Id, aadA, qnrS2, rpoB2, mexF, and oprN were found to confer resistance to various antibiotics.
Higher prevalence of multidrug-resistant extended-spectrum β-lactamases producing Escherichia coli in unorganized pig farms compared to organized pig farms in Mizoram, India.
The study identified several AMR genes, including bla TEM, bla CTX-M, bla CMY, tetA, tetB, sul1, sul2, aadA, and dfrIa, in multidrug-resistant E. coli isolates from both organized and unorganized pig farms in Mizoram, India.
Effects of in ovo probiotic administration on the incidence of avian pathogenic Escherichia coli in broilers and an evaluation on its virulence and antimicrobial resistance properties.
The study identified various antimicrobial resistance genes in APEC isolates, including blaTEM, aac(3)-VIa, aac(3)-VIb, aadA, tetA, tetB, dfr7, qacEΔ, qnr, sul1, intl1, arsC, and merA. These genes conferred resistance to multiple antibiotics such as beta-lactams, aminoglycosides, tetracyclines, quinolones, sulfonamides, and heavy metals.
Distribution of Beta-Lactamase Producing Gram-Negative Bacterial Isolates in Isabela River of Santo Domingo, Dominican Republic.
The study identified several beta-lactamase genes, including bla TEM, bla OXA, bla SHV, and bla KPC, as well as other resistance genes such as CTX-M-15, CTX-M-55, OXA-1, OXA-72, OXA-132, KPC-3, QnrS1, QnrB19, sul2, sul1, dfrA12, dfrA14, dfrA17, mphA, aadA, aadA2, aadA5, ampC, ampC1, ampH, PmrF, bacA, and eptA, in various Gram-negative bacterial isolates from the Isabela River in the Dominican Republic.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Genetic Characterization of AmpC and Extended-Spectrum Beta-Lactamase Phenotypes in Escherichia coli and Salmonella From Alberta Broiler Chickens.
The study identified bla CMY-2 and bla TEM genes in E. coli and Salmonella isolates from Alberta broiler chickens, contributing to beta-lactam resistance. Additionally, aadA, aadA1a, and aadA2 genes were found to confer resistance to streptomycin.
Comprehensive Pathogen Identification, Antibiotic Resistance, and Virulence Genes Prediction Directly From Simulated Blood Samples and Positive Blood Cultures by Nanopore Metagenomic Sequencing.
The study demonstrates the use of nanopore sequencing for rapid identification of pathogens, antibiotic resistance genes, and virulence genes from simulated blood samples and positive blood cultures. It identified 39 antibiotic resistance genes and 77 virulence genes in a Klebsiella pneumoniae strain, including blaKPC-2, blaSHV-12, blaTEM-1, blaCTX-M-65, rmtB, aadA, AAC(6')-IIb, baeR, mdtABC, acrAB, oqxAB, tet, H-NS, gyrA, and parC.
The Link between Occurrence of Class I Integron and Acquired Aminoglycoside Resistance in Clinical MRSA Isolates.
The study reveals that the aacA4 gene and class I integrons harboring the aadA gene are predominant in MRSA isolates, contributing to aminoglycoside resistance.
Comparative Characteristics and Zoonotic Potential of Avian Pathogenic Escherichia coli (APEC) Isolates from Chicken and Duck in South Korea.
The study identified several antimicrobial resistance genes in APEC isolates from chickens and ducks in South Korea, including mcr-1, blaTEM, blaCTX-M group I, blaCTX-M group IV, mphA, cat, floR, cmlA, strA-B, aadA, sul1, sul2, tetA, and tetB. These genes conferred resistance to various antibiotics such as colistin, ampicillin, azithromycin, chloramphenicol, streptomycin, sulfisoxazole, and tetracycline. The study also highlighted the zoonotic potential of certain APEC isolates, particularly those belonging to phylogenetic group B2.
mcr-1 Identified in Fecal Escherichia coli and Avian Pathogenic E. coli (APEC) From Brazil.
The study identified the mcr-1 and mcr-5 genes in Escherichia coli isolates from poultry in Brazil, highlighting the presence of colistin resistance in avian pathogens.
Detection and Characterization of Clinical Bordetella trematum Isolates from Chronic Wounds.
The study identified the presence of sul2, aminoglycoside resistance gene aadA, fosfomycin resistance gene fosA, and fluoroquinolone resistance gene gyrB in all three B. trematum isolates. Additionally, isolate two carried a beta-lactamase gene (bla) conferring resistance to ampicillin and ampicillin/sulbactam.
Metagenomic analysis of MWWTP effluent treated via solar photo-Fenton at neutral pH: Effects upon microbial community, priority pathogens, and antibiotic resistance genes.
Solar photo-Fenton treatment effectively removed a wide range of antibiotic resistance genes (ARGs) including those conferring resistance to sulfonamides, macrolides, tetracyclines, and beta-lactams. The study identified several ARGs such as sul1, sul2, tet(X), erm(F), mph(A), mph(E), msr(E), aadA, aph(3"), aph(6), strA, and blaBKC.
Virulence and Antibiotic Resistance Characteristics of Vibrio Isolates From Rustic Environmental Freshwaters.
The study identified several antibiotic resistance genes in Vibrio isolates from environmental freshwater sources, including aadA, strA, aphA1, catII, ampC, blaTEM, blaGES, blaOXA-48, blaIMP, blaVIM, blaKPC, and qnrVC, indicating a significant risk of antimicrobial resistance in these bacteria.
Prevalence, antibiotic susceptibility, and presence of drug resistance genes in Aeromonas spp. isolated from freshwater fish in Kelantan and Terengganu states, Malaysia.
The study identified multiple antibiotic resistance genes in Aeromonas spp. isolated from freshwater fish in Malaysia, including blaTEM, blaSHV, sul1, aadA, strA-strB, tetA, and tetE, which confer resistance to ampicillin, sulfamethoxazole, streptomycin, and tetracycline.
Occurrence of Colibacillosis in Broilers and Its Relationship With Avian Pathogenic Escherichia coli (APEC) Population Structure and Molecular Characteristics.
The study identified multiple antimicrobial resistance genes in Avian Pathogenic Escherichia coli (APEC) isolates, including beta-lactamases (blaCMY-2, blaSHV-12, blaTEM-52, blaCTX-M-1), aminoglycoside resistance genes (aac(3)-IV, aadA, strA, strB, aph(3')-Ib), sulfonamide resistance gene (sul1), tetracycline resistance genes (tet(A), tet(B)), trimethoprim resistance gene (dfrA), quinolone resistance genes (qnrS1, qnrS2, qnrB19), macrolide resistance genes (mph(A), mph(B)), and chloramphenicol resistance gene (catA1).
Antimicrobial Susceptibility and Detection of Virulence-Associated Genes in Escherichia coli Strains Isolated from Commercial Broilers.
The study identified several AMR genes in E. coli strains from commercial broilers, including bla CTX-M-1 and bla CTX-M-2 for cephalosporin resistance, qnrA, qnrB, qnrS for fluoroquinolone resistance, aac(6')-Ib-cr for fluoroquinolone and aminoglycoside resistance, tetA and tetB for tetracycline resistance, sul1 and sul2 for sulfonamide resistance, aadA for aminoglycoside resistance, dfrA and dfrB for trimethoprim resistance, and mcr1 and mcr2 for polymyxin resistance.
Clinical outcomes, molecular epidemiology and resistance mechanisms of multidrug-resistant Pseudomonas aeruginosa isolated from bloodstream infections from Qatar.
The study identified several AMR genes and mutations in MDR P. aeruginosa isolates from Qatar, including blaVIM, blaOXA-50, aac(6')-Ib, aadA, ant(2')-Ia, aph(3')-IIb, qnrS1, crpP, gyrA(T83I), parC(S83I), parE(A473V), pbp3(D350N, S357N), and ompK37(M70I, M128I). These resistance mechanisms contribute to the multidrug-resistant phenotype observed in the isolates.
Prevalence and Antimicrobial Resistance Profiles of Foodborne Pathogens Isolated from Dairy Cattle and Poultry Manure Amended Farms in Northeastern Ohio, the United States.
The study identified several antimicrobial resistance genes in foodborne pathogens isolated from dairy cattle and poultry manure amended farms in Northeastern Ohio, including mphA, aadA, aphA1, tetA, aac(3)-IV, sulII, blaTEM, tetB, strA, aac(3)-Iva, ampC, lde, ermB, tet(O), aadB, penA, blaOXA-61, aadE, and aph-3-1.
The Genomic Characterization of KPC-Producing Klebsiella pneumoniae from the ICU of a Teaching Hospital in Shanghai, China.
The study identified the carbapenemase gene blaKPC-2 and blaKPC-24, along with fosfomycin resistance gene fosA6, and various extended-spectrum beta-lactamase genes such as blaCTX-M-15, blaCTX-M-65, and blaCTX-M-27 in KPC-producing Klebsiella pneumoniae strains. Additionally, genes associated with fluoroquinolone, macrolide, aminoglycoside, and sulfonamide resistance were also characterized.
Genetic diversity and multidrug resistance of phylogenic groups B2 and D in InPEC and ExPEC isolated from chickens in Central China.
The study identifies several AMR genes and mutations in E. coli isolates from chickens in Central China, including aminoglycoside resistance genes strA, strB, and aadA, beta-lactamase genes CTX-M, SHV, OXA, and TEM, and quinolone resistance mutations S83L and D87N in gyrA.
Dissemination of antimicrobial-resistant isolates of Salmonella spp. in wild boars and its relationship with management practices.
The study identifies several AMR genes in Salmonella isolates from wild boars, including sul1, sul2, sul3, aadA1, strA, strB, tetA, tetB, blaTEM, gyrA, and int1, which confer resistance to sulfonamides, aminoglycosides, tetracyclines, beta-lactams, quinolones, and phenicols. The presence of these genes highlights the role of management practices in the dissemination of AMR.
First Description of Ceftazidime/Avibactam Resistance in a ST13 KPC-70-Producing Klebsiella pneumoniae Strain from Portugal.
The study reports the first description of ceftazidime/avibactam resistance in a ST13 KPC-70-producing Klebsiella pneumoniae strain from Portugal. The strain was found to harbor the blaKPC-70 gene, a variant of blaKPC-3 with two amino acid substitutions (D179Y and T263A), which conferred resistance to several β-lactam antibiotics.
Yersinia pestis antibiotic resistance: a systematic review.
Healthcare-associated infections caused by chlorhexidine-tolerant Serratia marcescens carrying a promiscuous IncHI2 multi-drug resistance plasmid in a veterinary hospital.
The study identifies multiple antimicrobial resistance genes in Serratia spp. isolates from hospitalized animals, highlighting the presence of a promiscuous IncHI2 plasmid carrying resistance genes against several high-importance antimicrobials.
Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.
The review identified several AMR genes in pathogens associated with calf diarrhea and pneumonia, including beta-lactamases (blaCMY, blaCTX-M, blaTEM), tetracycline resistance genes (tetA, tetB, tetM, tetO), aminoglycoside resistance genes (strA, strB, aadA), sulfonamide resistance genes (sul1, sul2), phenicol resistance genes (cat, floR), and macrolide/lincosamide resistance genes (cfr, ermB).
Molecular Characteristics of Antimicrobial Resistance and Virulence in Klebsiella pneumoniae Strains Isolated from Goose Farms in Hainan, China.
The study identified bla NDM-5 as a prevalent carbapenem resistance gene in Klebsiella pneumoniae isolates from goose farms in Hainan, China. Additionally, other resistance genes such as bla CTX-M, aadA, oqxAB, tet, and mcr-1 were also detected, highlighting the complex resistance profiles of these isolates.
Wild Duck (Anas platyrhynchos) as a Source of Antibiotic-Resistant Salmonella enterica subsp. diarizonae The First Report in Poland.
The study identified the presence of aadA, strA/strB, and blaTEM genes in a multidrug-resistant Salmonella enterica subsp. diarizonae strain isolated from a wild mallard duck in Poland.
Genomic Analysis of Carbapenem-Resistant Comamonas in Water Matrices: Implications for Public Health and Wastewater Treatments.
The study identifies carbapenem-resistant Comamonas denitrificans isolates carrying genomic islands encoding carbapenemase blaGES-5 and extended-spectrum beta-lactamase blaOXA alleles, along with aminoglycoside resistance genes aadA and detergent resistance gene qacL.
Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.
The study identifies several AMR genes and mutations associated with resistance to various antibiotics in wastewater environments, highlighting the role of these genes in the spread of antimicrobial resistance.
Hitherto-Unnoticed Self-Transmissible Plasmids Widely Distributed among Different Environments in Japan.
The study identified new subgroups of IncP/P-1 and PromA plasmids, including antibiotic resistance genes such as blaIMP-1, blaKPC-2, mcr-1, and various tetracycline and aminoglycoside resistance genes.
Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from South American camelids in Germany, highlighting the presence of multidrug-resistant strains and the importance of monitoring AMR in these animals.
Salmonella Derby from pig production chain over a 10-year period: antimicrobial resistance, biofilm formation, and genetic relatedness.
The study identified resistance genes blaTEM, aadA, tetA, and floR in Salmonella Derby isolates, which conferred resistance to ampicillin, streptomycin/spectinomycin, tetracycline, and florfenicol, respectively.
Comparative genomics analysis of the multidrug-resistant Aeromonas hydrophila MX16A providing insights into antibiotic resistance genes.
The study identified multiple antibiotic resistance genes in Aeromonas hydrophila MX16A, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and quinolone resistance determinants, contributing to its multidrug-resistant phenotype.
The pan-genome of the emerging multidrug-resistant pathogen Corynebacterium striatum.
The study identifies 15 antimicrobial resistance genes in Corynebacterium striatum, including genes conferring resistance to aminoglycosides, tetracyclines, chloramphenicol, macrolides, lincosamides, streptogramins, sulfonamides, and cationic antiseptics. These genes are often located in genomic islands and mobile genetic elements, highlighting the role of horizontal gene transfer in the spread of multidrug resistance.
In Vitro Assessment of Antimicrobial Activity of Phytobiotics Composition towards of Avian Pathogenic Escherichia coli (APEC) and Other E. coli Strains Isolated from Broiler Chickens.
The study identifies several AMR genes in E. coli strains, including aadA, strA/strB, aphA1, aphA2, tetA, tetB, sul1, sul2, sul3, dfrA1, dfrA10, dfrA12, floR, and blaSHV, which confer resistance to various antibiotics such as streptomycin, neomycin, tetracycline, sulfonamides, trimethoprim, chloramphenicol, and cephalosporins.
Antimicrobial resistance profile of Escherichia coli isolated from poultry litter.
The study identified various antimicrobial resistance genes in E. coli isolates from poultry litter, including groEL, tetA, aadA, aph(3)IA, silP, pcoD, sull, qacEdelta1, iroN, ompTp, and hlyF, which were associated with resistance to multiple antibiotics such as cephalothin, tetracycline, ampicillin, streptomycin, and sulphonamides.
Molecular and Antimicrobial Susceptibility Characterization of Escherichia coli Isolates from Bovine Slaughterhouse Process.
The study identified several AMR genes including tetA, strB, aadA, tetB, aac(3)IV, and strA in E. coli isolates from bovine slaughterhouse samples, highlighting the prevalence of tetracycline and streptomycin resistance.
Prevalence and Characterization of Salmonella Isolated from Chickens in Anhui, China.
The study identified several AMR genes in Salmonella isolates from chickens in Anhui, China, including blaTEM, blaCMY-2, aadA, strA, aph(3')-IIa, aac(6')-Ib-cr, qnrB, qnrS, sul1, sul2, tetA, tetB, cat1, and floR. These genes were associated with resistance to various antibiotics such as ampicillin, cephalosporins, streptomycin, gentamicin, amikacin, fluoroquinolones, sulfamethoxazole, tetracycline, chloramphenicol, and florfenicol.
Reduced selection for antibiotic resistance in community context is maintained despite pressure by additional antibiotics.
The study characterizes the resistance genes aacC1, aphA, and aadA, which confer resistance to gentamicin, kanamycin, and streptomycin, respectively, in Escherichia coli MG1655. These genes were experimentally validated through chromosomal tagging and electroporation techniques.
ARGs Detection in Listeria Monocytogenes Strains Isolated from the Atlantic Salmon (Salmo salar) Food Industry: A Retrospective Study.
The study identified various AMR genes in L. monocytogenes strains from Atlantic salmon, including tetracycline resistance genes (tetC, tetD, tetK, tetL, tetS), aminoglycoside resistance genes (aadA, strA, aacC2, aphA1, aphA2), macrolide resistance genes (cmlA1, catI, catII), and oxazolidinone resistance genes (cfr, optrA, poxtA).
On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective.
The study identifies several AMR genes and mutations associated with streptomycin, kasugamycin, gentamicin, and oxytetracycline resistance in plant pathogenic bacteria, highlighting the role of Tn 5393 and other mobile genetic elements in the dissemination of these resistance traits.
Genetic Diversity and Antimicrobial Resistance of Extraintestinal E. coli Populations Pre- and Post-Antimicrobial Therapy on Broilers Affected by Colisepticemia.
The study identified several AMR genes and mutations in extraintestinal E. coli populations from broilers treated with enrofloxacin. Key findings include the presence of qnrB19 and qnrS1 genes, which confer fluoroquinolone resistance, and mutations in gyrA, parC, and parE genes associated with fluoroquinolone resistance. Additionally, multiple other AMR genes were detected, indicating multidrug resistance.
Isolation and Characterization of the Acadevirus Members BigMira and MidiMira Infecting a Highly Pathogenic Proteus mirabilis Strain.
The study identifies multiple antibiotic resistance genes in the highly pathogenic Proteus mirabilis strain MCS, highlighting its multidrug-resistant profile. Key genes include tetA, aac(6')-Iq, aac(6')-Ib', aadA, dfrA1, blaOXA-9, blaCTX-M-2, vat, catA2, sul1, qacEdeltal, tetQ, blaTEM-135, aadA2, aph(3')-Ia, aph(6)-Id, aph(3'')-lb, and sulI.
Decoding the genetic structure of conjugative plasmids in international clones of Klebsiella pneumoniae: A deep dive into blaKPC, blaNDM, blaOXA-48, and blaGES genes.
The study characterizes the genetic structure of plasmids harboring major carbapenemase genes (blaKPC, blaNDM, blaOXA-48, and blaGES) in Klebsiella pneumoniae, identifying the most prevalent allele types and their co-occurrence with other resistance genes.
Beta-lactam, aminoglycoside, and quinolone resistance in Escherichia coli strains isolated from shrimps and mussels in the Marmara Sea.
The study identified bla TEM and bla CTX-M-1 as ESBL genes, strB, aadA, aphA1, and aphA2 as aminoglycoside resistance genes, and aac(6')-Ib-cr as a quinolone resistance gene in E. coli isolates from shrimps and mussels in the Marmara Sea.
Deciphering the Role of WWTPs in Cold Environments as Hotspots for the Dissemination of Antibiotic Resistance Genes.
The study identified several antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in cold environments, highlighting their role as hotspots for the dissemination of ARGs. Key genes included aadA, aadB, ampC, blaSHV, blaTEM, dfrA1, ermB, fosA, qnrS, and tetA(A).
Characterization of Riemerella anatipestifer Strains Isolated from Various Poultry Species in Poland.
The study identified several AMR genes in R. anatipestifer isolates, including aminoglycoside resistance genes (aph(3′)-VII, aac(3′)-IV, aadA, strA/strB), tetracycline resistance genes (tet(A), tet(B), tet(X)), erythromycin resistance gene (ermF), chloramphenicol resistance gene (cmlA), beta-lactam resistance gene (bla TEM), and sulfonamide resistance gene (sulI).
Predicting Salmonella MIC and Deciphering Genomic Determinants of Antibiotic Resistance and Susceptibility.
The study presents a novel 'Genome Feature Extractor Pipeline' that uses machine learning and deep learning to predict Salmonella MIC values based on 20-mer counts from WGS data. The pipeline identifies key genomic features associated with antibiotic resistance, including known resistance genes such as beta-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes, tetracycline efflux pumps, and sulfonamide resistance genes.
Klebsiella pneumoniae ST147 harboring bla(NDM-1), multidrug resistance and hypervirulence plasmids.
The study identifies the blaNDM-1 gene and various other resistance genes in multidrug-resistant Klebsiella pneumoniae ST147 strains, highlighting their role in carbapenem resistance and hypervirulence.
Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens.
The study identifies numerous antibiotic resistance genes (ARGs) that are transferred between plasmids, particularly beta-lactamases (bla TEM-1, bla NDM-4, bla KPC-2, bla SHV-1), aminoglycoside resistance gene aacC1, and colistin resistance gene mcr-1. These genes are shown to transfer between compatible plasmids in clinical pathogens, accelerating the spread of antibiotic resistance.
Occurrence and molecular characteristics of antimicrobial resistance, virulence factors, and extended-spectrum β-lactamase (ESBL) producing Salmonella enterica and Escherichia coli isolated from the retail produce commodities in Bangkok, Thailand.
The study identified several AMR genes and mutations in Salmonella enterica and Escherichia coli isolated from retail produce in Bangkok, Thailand. Key findings include the presence of bla TEM, qnrS, tetA, tetB, strA, and strB genes, as well as gyrA and parC mutations associated with ciprofloxacin resistance.
Antimicrobial Resistance and Molecular Characterization of Salmonella Rissen Isolated in China During 2008-2019.
The study identified multiple AMR genes in Salmonella Rissen isolates from China, including blaTEM, sul2, sul3, tetA, strA, strB, aadA, intl1VR(cx), and qacED1, which contribute to resistance against various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, tetracycline, and streptomycin.
Causal-ARG: A Causal Representation Learning Framework for Annotating Antimicrobial Resistance Genes
The paper proposes a causality-guided framework called Causal-ARG for annotating properties of antibiotic resistance genes (ARGs), focusing on antibiotic class, resistance mechanism, and transferability.
Design and Validation of Primer Sets for the Detection and Quantification of Antibiotic Resistance Genes in Environmental Samples by Quantitative PCR.
The study presents eleven novel primer sets for the detection and quantification of antibiotic resistance genes (ARGs) in environmental samples using qPCR. These primers target genes such as aadA, aadB, ampC, blaTEM, blaSHV, dfrA1, ermB, fosA, mecA, qnrS, and tetA(A), which are responsible for resistance to various antibiotics including aminoglycosides, beta-lactams, trimethoprim, macrolides, fosfomycin, quinolones, and tetracyclines.
Prevalence of antibiotic-resistant Acinetobacter spp. on soil and crops collected from agricultural fields in South Korea.
The study identified several antibiotic resistance genes in Acinetobacter spp. isolated from agricultural fields in South Korea, including emrAB, cat, craA, and aadA, which confer resistance to colistin, chloramphenicol, and streptomycin.
Detection of Salmonella Pathogenicity Islands and Antimicrobial-Resistant Genes in Salmonella enterica Serovars Enteritidis and Typhimurium Isolated from Broiler Chickens.
The study identified several antimicrobial-resistant genes in Salmonella enterica serovars Enteritidis and Typhimurium isolated from broiler chickens, including tet(K), tet(O), tet(A), mcr-1, mcr-4, strA, strB, aadA, aadE, sulI, ampC, TEM, CTX-M, and OXA. These genes conferred resistance to tetracycline, colistin, aminoglycosides, sulfonamides, and beta-lactam antibiotics.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Selection and horizontal gene transfer underlie microdiversity-level heterogeneity in resistance gene fate during wastewater treatment.
The study identifies several resistance genes, including mphA, msrE, tet(39), sul1, sul2, mer, qac, and aadA, which were found to be associated with hospital sewage and showed variations in their persistence in activated sludge. These genes contribute to resistance against macrolides, tetracyclines, sulfonamides, mercury, quaternary ammonium compounds, and aminoglycosides.
Unde venis? Bacterial resistance from environmental reservoirs to lettuce: tracking microbiome and resistome over a growth period.
The study identified multidrug and β-lactam antibiotic resistance genes (ARGs) in lettuce and water, while lettuce and soil uniquely shared mainly glycopeptide and tetracycline ARGs. Manure was found to be the main source of resistance markers on young lettuce plants.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
Contribution of the Mobilome to the Configuration of the Resistome of Corynebacterium striatum.
The study identified 20 antimicrobial resistance genes in Corynebacterium striatum, with ErmX being the most prevalent. These genes are mainly associated with plasmid sequence regions and class 1 integrons, highlighting the role of mobile genetic elements in the dissemination of resistance.
Determinants of Antibiotic Resistance and Virulence Factors in the Genome of Escherichia coli APEC 36 Strain Isolated from a Broiler Chicken with Generalized Colibacillosis.
The study identifies multiple antibiotic resistance genes in the E. coli APEC 36 strain, including beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and efflux pumps, indicating a high level of multidrug resistance.
Determinants of Antibiotic Resistance and Virulence Factors in the Genome of Escherichia coli APEC 36 Strain Isolated from a Broiler Chicken with Generalized Colibacillosis.
The study identifies multiple antibiotic resistance genes in the E. coli APEC 36 strain, including beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and efflux pumps, indicating a high level of multidrug resistance.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
The study identified various AMR genes in Shigella isolates from Fujian Province, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CTX-M-64), macrolide resistance genes (mphA, ermB), tetracycline resistance genes (tetA, tetB), aminoglycoside resistance genes (aadA, aph(3')-Ib, aac(3)-IId), chloramphenicol resistance gene (catA1), and sulfonamide/trimethoprim resistance genes (sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA17).
Evaluating the health risk of probiotic supplements from the perspective of antimicrobial resistance.
Probiotics from health supplements were found to harbor ARGs conferring resistance to tetracycline, macrolide, aminoglycoside, and glycopeptide antibiotics. Specifically, aadA and erm(B)-1 were detected in transconjugants after co-incubation with streptomycin-adapted probiotics.
Whole-genome sequencing of Acinetobacter baumannii clinical isolates from a tertiary hospital in Terengganu, Malaysia (2011-2020), revealed the predominance of the Global Clone 2 lineage.
The study identified the predominance of the Global Clone 2 lineage of Acinetobacter baumannii in Terengganu, Malaysia, with a focus on the detection of various antimicrobial resistance genes, including bla OXA-23, bla ADC, bla NDM-1, and others, contributing to multidrug resistance.
Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.
The study identified several clinically relevant antimicrobial resistance genes (ARGs) in bovine respiratory disease (BRD) pathogens, including estT, floR, mphE, erm(42), msrE, aadA, ANT(2''-Ia), APH(3''-Ib), APH(3'-Ia), APH(6)-Id, sul2, tet(H), ROB-1, and OXA-2. Additionally, mutations in gyrA and parC were found to confer resistance to fluoroquinolones in Mannheimia haemolytica.
Strict relationship between phenotypic and plasmid-associated genotypic of multidrug-resistant Escherichia coli isolated from Taihe Black-Boned Silky Fowl farms.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from Taihe Black-Boned Silky Fowl farms, including blaTEM, blaOXA-10, tetA, tetR, floR, cmlA, qnrS, strA, strB, aadA, aac(3)-IId, sul, and dfrA. These genes were associated with resistance to beta-lactams, tetracyclines, chloramphenicol, fluoroquinolones, aminoglycosides, and sulfonamides.
Providencia pseudovermicola sp. nov.: redefining Providencia vermicola and unveiling multidrug-resistant strains from diabetic foot ulcers in Egypt.
The study identifies multiple multidrug-resistant genes in Providencia pseudovermicola sp. nov., including bla CTX-M-14, bla CMY-6, bla NDM-1, qnrD1, aadA, armA, msrE, mphE, lnuF, rmtC, aac(6')-Ib10, sul1, aph(3')-Ia, qacEΔ1, and dfrA1, highlighting the significance of these genes in conferring resistance to various antibiotics.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Comparative genomics of Pseudomonas paraeruginosa.
The study identifies various AMR genes and mutations in Pseudomonas paraeruginosa, including carbapenemases like blaVIM-2, blaVIM-6, blaVIM-28, and blaKPC-2, as well as efflux pump genes (mexAB-oprM, mexCD-oprJ, etc.), and mutations in oprD, mexS, mexR, mexZ, lasR, mvfR, and vqsM that contribute to antibiotic resistance.
Epidemiology of potential source, risk attribution of Clostridium perfringens from Egyptian broiler farms and genetic diversity of multidrug resistance strains.
The study identified multiple AMR genes in Clostridium perfringens isolates from Egyptian broiler farms, including aminoglycoside, beta-lactam, macrolide, quinolone, sulfonamide, tetracycline, and trimethoprim resistance genes. High prevalence of multidrug-resistant strains was observed.
Antibiotic resistance and novel Sequence Types of Klebsiella spp. in human, animal, and food sources: a One Health perspective from Northern Nigeria.
The study identified various AMR genes in Klebsiella spp. isolates from human, animal, and food sources, including strB, qnrS1, sul2, tetA, dfrA14, blaTEM-1, and blaSHV-11, which conferred resistance to multiple antibiotics.
Multidrug-resistant Pseudomonas aeruginosa: Pathogenesis, resistance mechanisms, and novel therapeutic strategies.
The paper discusses the multidrug resistance mechanisms of Pseudomonas aeruginosa, including beta-lactamases, aminoglycoside modifying enzymes, efflux pumps, and mutations in porin genes. It highlights the role of these mechanisms in antibiotic resistance and the challenges they pose in treating infections.
Acquisition of novel antibiotic resistance genes by the bacterial predator Bacteriovorax sp. As-1.
Bacteriovorax sp. As-1 exhibits resistance to multiple antibiotics, primarily due to mutations in the gyrA gene, specifically S90Y and G94R, which are associated with reduced fluoroquinolone susceptibility.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Geographics and bacterial networks differently shape the acquired and latent global sewage resistomes.
The study identifies several AMR genes, including aph(6)-id_2, mef(c), mef(b), mph(e), mph(g), msr(d), lnu(b), lnu(d), aadA, ant(6)-Ia, blaCTX-M, blaTEM, blaSHV, blaOXA, qnrS1, mcr-1, and vanA, which are associated with resistance to various antibiotics such as aminoglycosides, macrolides, lincosamides, beta-lactams, fluoroquinolones, polymyxins, and glycopeptides.
Genomic characterization of two distinct Klebsiella pneumoniae strains in a fatal case of relapsed acute myelogenous leukemia: a case report.
The study identified two distinct Klebsiella pneumoniae strains, ST147 and ST967, with varying resistance profiles. ST147 isolates harbored multiple resistance genes including bla OXA−181, aadA, aadA5, bla CTX−M−15, bla OXA−1, bla SHV−11, bla TEM−1, sul1, qnrS1, and tet(A), while ST967 had a more limited resistome with aac(3)-IIa, bla SHV−27, and dfrA14.
Genomic Characterization and Resistance Mechanisms of Carbapenem-Resistant Klebsiella pneumoniae ST101 Isolates from Saudi Arabia.
The study identifies bla_OXA-48 and bla_NDM-1 carbapenemase genes in CRKP ST101 isolates from Saudi Arabia, highlighting their role in carbapenem resistance and the complexity of resistance mechanisms in high-risk clones.
Genetic organization of antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331.
The study characterizes the genetic organization of three antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) within the multiresistance transposon Tn1331, demonstrating their transcriptional regulation and functional roles in conferring resistance to gentamicin, tobramycin, streptomycin, and ampicillin in Escherichia coli.
Detection of a streptomycin/spectinomycin adenylyltransferase gene (aadA) in Enterococcus faecalis.
The study identified the aadA gene in Enterococcus faecalis, which confers resistance to streptomycin and spectinomycin through enzymatic modification.
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