Browse AMR Genes

Explore antimicrobial resistance genes from the literature

aadA21

aminoglycoside adenyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to aadA21

Browse AMR rules for aadA21

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic modification
Validation Method: PCR and DNA sequencing
Drug Classes: streptomycin, SPECTINOMYCIN, AMINOGLYCOSIDE ANTIBIOTIC
Organisms: Salmonella enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Rissen
Geographic Location: Czech Republic
Alleles: 2
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
AadA21	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	6	streptomycin, SPECTINOMYCIN	Salmonella enterica serovar Typhimurium +2	Czech Republic	2003, 2007	AY171244	AAN87151.1
ANT(3'')	Card Database	1	SPECTINOMYCIN, AMINOGLYCOSIDE ANTIBIOTIC +1	Salmonella enterica subsp. enterica serovar Typhimurium	-	-	AY171244.1	AAN87151.1

Papers2

1

Evolution of antibiotic resistance in Salmonella enterica serovar typhimurium strains isolated in the Czech Republic between 1984 and 2002.

Research Article

PMID 12760885 · 2003

The study identifies the aadA21 gene, a novel variant of the aadA gene, and other resistance genes such as blaPSE-1, floR, sul1, and tetG in Salmonella enterica serovar Typhimurium strains from the Czech Republic between 1984 and 2002.

Gene Information

Gene Name: aadA21
Allele: AadA21
Encodes: aminoglycoside adenyltransferase
Source Database: Reslit
Confers Resistance To: streptomycin
Organisms Tested In: • Salmonella enterica serovar Typhimurium
Geographic Location: Czech Republic
Validation Method: PCR and DNA sequencing
Sequence Accession: AY171244

2

Evolution of antibiotic resistance in Salmonella enterica serovar typhimurium strains isolated in the Czech Republic between 1984 and 2002.

Research Article

PMID 12760885 · 2003

Gene Information

Gene Name: aadA21
Allele: AadA21
Encodes: ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA21
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: SPECTINOMYCINSTREPTOMYCIN
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhimurium
Sequence Accession: AY171244.1
Protein Accession: AAN87151.1
Notes: ARO:3002618

3

Evolution of antibiotic resistance in Salmonella enterica serovar typhimurium strains isolated in the Czech Republic between 1984 and 2002.

Research Article

PMID 12760885 · 2003

Gene Information

Gene Name: aadA21
Allele: AadA21
Encodes: ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA21
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: SPECTINOMYCINSTREPTOMYCIN
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhimurium
Sequence Accession: AY171244.1
Protein Accession: AAN87151.1
Notes: ARO:3002618

4

Evolution of antibiotic resistance in Salmonella enterica serovar typhimurium strains isolated in the Czech Republic between 1984 and 2002.

Research Article

PMID 12760885 · 2003

Gene Information

Gene Name: aadA21
Allele: AadA21
Encodes: ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA21
Source Database: Card Database
Mechanism: Enzymatic modification
Confers Resistance To: SPECTINOMYCINSTREPTOMYCIN
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhimurium
Sequence Accession: AY171244.1
Protein Accession: AAN87151.1
Notes: ARO:3002618

5

Evolution of antibiotic resistance in Salmonella enterica serovar typhimurium strains isolated in the Czech Republic between 1984 and 2002.

Research Article

PMID 12760885 · 2003

Gene Information

Gene Name: aadA21
Allele: aadA21
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: STREPTOMYCINSPECTINOMYCIN
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhimurium
Sequence Accession: AY171244

6

Gene Information

Gene Name: aadA21
Allele: ANT(3'')
Encodes: ANT(3'')
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: SPECTINOMYCINAMINOGLYCOSIDE ANTIBIOTICSTREPTOMYCIN
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhimurium
Sequence Accession: AY171244.1
Protein Accession: AAN87151.1
Notes: ARO:3002618

7

Dissemination of sul3-containing elements linked to class 1 integrons with an unusual 3' conserved sequence region among Salmonella isolates.

Research Article

PMID 17283193 · 2007

Gene Information

Gene Name: aadA21
Allele: AadA21
Encodes: ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA21
Source Database: Reference Gene Catalog
Confers Resistance To: STREPTOMYCIN
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Rissen
Sequence Accession: EF051038.1
Protein Accession: ABL95942.1

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