aada2cmla

Aminoglycoside adenyltransferase

Validation StatusCandidate

Overview

Mechanism: Modification of aminoglycoside antibiotics
Validation Method: Whole-genome sequencing and phenotypic resistance testing
Drug Classes: Aminoglycoside
Organisms: Escherichia coli
Geographic Location: Atlanta
Papers: 1
Databases: Reslit

Papers1

No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.

PMID 41059698 · 2025

The study identified several AMR genes and mutations in E. coli isolates from both humans and pets, including blaCMY-2, blaCTX-M-15, blaTEM-1B, and mutations in gyrA and parC. These findings highlight the presence of multidrug-resistant Enterobacterales in healthy individuals and their companion animals.

Gene Information

Gene Name: aada2cmla
Allele: aadA2cmlA
Encodes: Aminoglycoside adenyltransferase
Source Database: Reslit
Mechanism: Modification of aminoglycoside antibiotics
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Escherichia coli
Geographic Location: Atlanta
Validation Method: Whole-genome sequencing and phenotypic resistance testing
Sequence Accession: SAMN29011448

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aada2cmla

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