aadb

aminoglycoside adenyltransferase

Validation StatusCandidate

Overview

Mechanism: The aadB gene encodes an aminoglycoside adenyltransferase, which confers resistance to kanamycin, tobramycin, and gentamicin.
Validation Method: cloning in E. coli and MIC testing
Organisms: Escherichia coli, Salmonella enterica serovar Typhimurium
Geographic Location: Italy
Papers: 2
Databases: Reslit

Papers2

Characterization of In53, a class 1 plasmid- and composite transposon-located integron of Escherichia coli which carries an unusual array of gene cassettes.

PMID 11114922 · 2001

The study characterizes In53, a unique class 1 integron in Escherichia coli that carries multiple antibiotic resistance gene cassettes, including aadB, arr-2, cmlA5, qacI, aacA1b/orfG, oxa10, and aadA1, each contributing to resistance against various antibiotics.

Gene Information

Gene Name: aadb
Allele: aadB
Encodes: aminoglycoside adenyltransferase
Source Database: Reslit
Mechanism: The aadB gene encodes an aminoglycoside adenyltransferase, which confers resistance to kanamycin, tobramycin, and gentamicin.
Organisms Tested In: • Escherichia coli
Validation Method: cloning in E. coli and MIC testing
Sequence Accession: AF205943

Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.

PMID 15728925 · 2005

The study identifies a novel trimethoprim resistance gene, dfrA23, on a Salmonella enterica serovar Typhimurium virulence plasmid, along with other resistance genes such as aadB, blaOXA-30, and aadA1.

Gene Information

Gene Name: aadb
Allele: aadB
Encodes: aminoglycoside adenyltransferase
Source Database: Reslit
Organisms Tested In: • Salmonella enterica serovar Typhimurium
• Escherichia coli
Geographic Location: Italy
Validation Method: PCR amplification and DNA sequencing
Sequence Accession: AJ746361

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