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Explore antimicrobial resistance genes from the literature
MATE efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S437T | - | - | Acinetobacter baumannii | Tetracycline | Reslit | Candidate |
Efflux-mediated antibiotic resistance in Acinetobacter spp.
The study characterizes several efflux pumps in Acinetobacter spp., including AdeABC, AdeIJK, AdeFGH, CraA, AmvA, AbeM, AbeS, AdeXYZ, AdeDE, TetA, TetB, CmlA, FloR, and QacE, which contribute to multidrug resistance by expelling antibiotics and other compounds.
Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China.
The study identifies several AMR genes and mutations in the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06, including bla oxa-23, armA, and various efflux pumps, contributing to resistance against multiple antibiotics.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii.
The study identifies multiple efflux pumps, porins, and β-lactamases contributing to multidrug resistance in Acinetobacter baumannii, including adeB, adeJ, tetB, tetA(39), and aacC1, aphA1, aadB genes, along with mutations in gyrA and parC.
Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China.
The study identified 19 drug resistance genes in 10 multidrug-resistant Acinetobacter baumannii strains, with efflux pump genes being the most prevalent. Key genes included aacA4, which had a 19-bp deletion associated with aminoglycoside resistance, and other genes like TEM-1, OXA-23, and ANT(3'')-IIa.
Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance.
The study identifies several efflux pumps in Acinetobacter baumannii, including AdeABC, AbeM, AbaF, and AbeS, which contribute to multidrug resistance. These pumps are involved in the efflux of various antibiotics and other antimicrobial agents.
Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii.
The paper discusses the antibiotic resistance profiles and molecular mechanisms of Acinetobacter baumannii, highlighting the presence of various beta-lactamases such as blaOXA-23, blaOXA-51, blaOXA-24/40, blaOXA-58, blaOXA-143, blaOXA-235, blaIMP, blaVIM, and blaNDM, as well as aminoglycoside-modifying enzymes like aac(6')-Ib, aph(3')-Ia, and ant(2'')-Ia. It also identifies efflux pumps such as adeABC and tetracycline resistance genes like tet(A).
Synergistic Antibacterial Activity of Combined Antimicrobials and the Clinical Outcome of Patients With Carbapenemase-Producing Acinetobacter baumannii Infection.
The study identified bla OXA--23 as the primary carbapenemase gene in CRAB strains, and overexpression of efflux pump genes adeB, adeJ, and abeM contributed to resistance. Polymyxin plus sulbactam showed the highest synergistic effect against CRAB.
Overexpression of Efflux Pumps, Mutations in the Pumps' Regulators, Chromosomal Mutations, and AAC(6′)-Ib-cr Are Associated With Fluoroquinolone Resistance in Diverse Sequence Types of Neonatal Septicaemic Acinetobacter baumannii: A 7-Year Single Center Study.
The study identifies aac(6')-Ib-cr as a significant contributor to fluoroquinolone resistance in Acinetobacter baumannii, alongside chromosomal mutations in gyrA and parC, and overexpression of efflux pumps regulated by adeR and adeS.
Biocide-tolerance and antibiotic-resistance in community environments and risk of direct transfers to humans: Unintended consequences of community-wide surface disinfecting during COVID-19?
The paper discusses the mechanisms of biocide tolerance and antibiotic resistance in bacteria, highlighting the role of mutations, horizontal gene transfer, efflux pumps, membrane alterations, and biofilms in developing resistance to disinfectants and antibiotics. It emphasizes the risks posed by the extensive use of disinfectants during the COVID-19 pandemic and the potential for increased antimicrobial resistance.
Efflux Pump Overexpression Profiling in Acinetobacter baumannii and Study of New 1-(1-Naphthylmethyl)-Piperazine Analogs as Potential Efflux Inhibitors.
The study identifies the overexpression of efflux pump genes such as adeJ, adeG, adeB, abeM, abaQ, and craA in Acinetobacter baumannii strains, contributing to fluoroquinolone resistance. It also evaluates new 1-(1-naphthylmethyl)-piperazine analogs as potential efflux pump inhibitors.
Upregulation of abeM, amvA, and qacEΔ1 efflux pump genes associated with resistance of Acinetobacter baumannii strains to disinfectants.
The study found that upregulation of abeM, amvA, and qacEΔ1 efflux pump genes is associated with resistance of Acinetobacter baumannii strains to disinfectants such as MICROZED ID-MAX, NANOSIL D2, and OPIDEX OPA.
Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii strains, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, contributing to multidrug resistance.
Genomic Characterization of Carbapenem-Resistant Acinetobacter baumannii (CRAB) in Mechanically Ventilated COVID-19 Patients and Impact of Infection Control Measures on Reducing CRAB Circulation during the Second Wave of the SARS-CoV-2 Pandemic in Milan, Italy.
The study identified various AMR genes in CRAB isolates, including blaOXA-23, aph(3''-Ib, aph(6)-Id, abeM, mexT, abeS, tetA, adeABC, adeJKL, OXA-66, ADC-73, OXA-127, and ADC-30, which contribute to resistance against carbapenems, aminoglycosides, fluoroquinolones, macrolides, tetracyclines, and multiple antibiotics.
Resistance mechanisms of tigecycline in Acinetobacter baumannii.
The study identifies several efflux pumps, outer membrane permeability alterations, and antibiotic target modifications as key mechanisms of tigecycline resistance in Acinetobacter baumannii.
Efflux-Related Carbapenem Resistance in Acinetobacter baumannii Is Associated with Two-Component Regulatory Efflux Systems' Alteration and Insertion of ΔAbaR25-Type Island Fragment.
Antimicrobial resistance and virulence factors analysis of a multidrug-resistant Acinetobacter baumannii isolated from chickens using whole-genome sequencing.
The study identified 41 antimicrobial resistance genes in the multidrug-resistant Acinetobacter baumannii Y03 isolate, including genes conferring resistance to beta-lactams, phenicols, macrolides, lincosamides, aminoglycosides, and nitrofurans.
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