Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
SMR efflux pump
Overview
Efflux-mediated antibiotic resistance in Acinetobacter spp.
The study characterizes several efflux pumps in Acinetobacter spp., including AdeABC, AdeIJK, AdeFGH, CraA, AmvA, AbeM, AbeS, AdeXYZ, AdeDE, TetA, TetB, CmlA, FloR, and QacE, which contribute to multidrug resistance by expelling antibiotics and other compounds.
Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance.
The study identified that the upregulation of adeB, adeJ, and macB genes is responsible for tigecycline resistance, while increased abeS expression is strongly related to amikacin resistance in multidrug-resistant Acinetobacter baumannii isolates.
Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China.
The study identified 19 drug resistance genes in 10 multidrug-resistant Acinetobacter baumannii strains, with efflux pump genes being the most prevalent. Key genes included aacA4, which had a 19-bp deletion associated with aminoglycoside resistance, and other genes like TEM-1, OXA-23, and ANT(3'')-IIa.
Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance.
The study identifies several efflux pumps in Acinetobacter baumannii, including AdeABC, AbeM, AbaF, and AbeS, which contribute to multidrug resistance. These pumps are involved in the efflux of various antibiotics and other antimicrobial agents.
Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii.
The paper discusses the antibiotic resistance profiles and molecular mechanisms of Acinetobacter baumannii, highlighting the presence of various beta-lactamases such as blaOXA-23, blaOXA-51, blaOXA-24/40, blaOXA-58, blaOXA-143, blaOXA-235, blaIMP, blaVIM, and blaNDM, as well as aminoglycoside-modifying enzymes like aac(6')-Ib, aph(3')-Ia, and ant(2'')-Ia. It also identifies efflux pumps such as adeABC and tetracycline resistance genes like tet(A).
Biocide-tolerance and antibiotic-resistance in community environments and risk of direct transfers to humans: Unintended consequences of community-wide surface disinfecting during COVID-19?
The paper discusses the mechanisms of biocide tolerance and antibiotic resistance in bacteria, highlighting the role of mutations, horizontal gene transfer, efflux pumps, membrane alterations, and biofilms in developing resistance to disinfectants and antibiotics. It emphasizes the risks posed by the extensive use of disinfectants during the COVID-19 pandemic and the potential for increased antimicrobial resistance.
Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt.
The study identified various AMR genes and mutations in multidrug-resistant Acinetobacter baumannii isolates from a pediatric cancer hospital in Egypt, highlighting the presence of bla NDM, bla OXA-23-like, bla OXA-51-like, and other resistance genes, along with mutations in pmrA and lptF contributing to colistin resistance.
Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii strains, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, contributing to multidrug resistance.
Whole genome sequence of pan drug-resistant clinical isolate of Acinetobacter baumannii ST1890.
The study identified multiple antibiotic resistance genes in the pan-drug-resistant Acinetobacter baumannii strain VJR422, including genes encoding beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps, contributing to resistance against various antibiotic classes.
Antimicrobial Resistance and Comparative Genomic Analysis of Elizabethkingia anophelis subsp. endophytica Isolated from Raw Milk.
The study reports the first isolation of Elizabethkingia anophelis subsp. endophytica from raw milk in Russia, highlighting its multidrug resistance and the presence of various AMR genes including beta-lactamases and efflux pumps.
In Vitro Activity of Sulbactam-Durlobactam against Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates: A Multicentre Report from Italy.
The study evaluated the in vitro activity of sulbactam-durlobactam (SUL-DUR) against 141 carbapenem-resistant A. baumannii isolates. It identified several resistance genes including blaOXA-20, blaOXA-58, blaOXA-66, blaADC-25, aac(6')-Ib3, aac(6')-Ib-cr, and mutations in gyrA (S81L) and parC (V104I, D105E). Additionally, mutations in PBP3 (Q488K and Y528H) were found in SUL-DUR resistant isolates.
Genomic Characterization of Carbapenem-Resistant Acinetobacter baumannii (CRAB) in Mechanically Ventilated COVID-19 Patients and Impact of Infection Control Measures on Reducing CRAB Circulation during the Second Wave of the SARS-CoV-2 Pandemic in Milan, Italy.
The study identified various AMR genes in CRAB isolates, including blaOXA-23, aph(3''-Ib, aph(6)-Id, abeM, mexT, abeS, tetA, adeABC, adeJKL, OXA-66, ADC-73, OXA-127, and ADC-30, which contribute to resistance against carbapenems, aminoglycosides, fluoroquinolones, macrolides, tetracyclines, and multiple antibiotics.
Genomic analysis of multidrug-resistant Delftia tsuruhatensis isolated from raw bovine milk.
The study identifies multiple efflux pump genes and a genus-specific OXA-926-like beta-lactamase in the multidrug-resistant Delftia tsuruhatensis strain MR-6/3H, contributing to resistance against various antibiotics.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Comprehensive molecular epidemiology of Acinetobacter baumannii from diverse sources in Nigeria.
The study identified 168 AMR genes in 189 Nigerian A. baumannii isolates, including blaADC-79, blaOXA-23, aph(3")-Ib, and others, highlighting the widespread presence of multidrug resistance.
Genomic and phenotypic characterization of six multidrug-resistant Acinetobacter pittii isolates.
The study identified multiple beta-lactamase genes, including blaOXA-72, blaOXA-272, and blaOXA-255, which confer resistance to carbapenems. Additionally, other resistance genes such as blaADC-245, blaADC-150, and others were found to confer resistance to cephalosporins. Efflux pump genes like adeF, abaQ, and abeS were associated with resistance to fluoroquinolones and tetracyclines. The gene lpsB was linked to colistin resistance.
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