accD6

carboxyltransferase subunit of acyl-coenzyme A carboxylase

Validation StatusCandidate

Overview

Validation Method: expression analysis and protein expression verification
Drug Classes: Isoniazid
Organisms: Mycobacterium tuberculosis, Mycobacterium smegmatis
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G115D	-	-	Mycobacterium tuberculosis	Isoniazid	Reslit	Candidate

Papers2

AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain.

PMID 21984794 · 2011

The study shows that the accD6 gene is essential for Mycobacterium tuberculosis but not for Mycobacterium smegmatis. It identifies an internal promoter (Pacc) for accD6 in M. tuberculosis, which allows for reduced expression of the gene without affecting viability.

Gene Information

Gene Name: accD6
Allele: accD6
Encodes: carboxyltransferase subunit of acyl-coenzyme A carboxylase
Source Database: Reslit
Organisms Tested In: • Mycobacterium tuberculosis
• Mycobacterium smegmatis
Validation Method: expression analysis and protein expression verification

Browse AMR Genes

accD6

Mutations

Gene Information