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Explore antimicrobial resistance genes from the literature
chlorhexidine efflux protein
Overview
Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins.
The study identified AceI as a novel chlorhexidine efflux protein in Acinetobacter baumannii, which confers resistance to chlorhexidine when expressed in E. coli.
Homologs of the Acinetobacter baumannii AceI transporter represent a new family of bacterial multidrug efflux systems.
The study identifies a new family of bacterial multidrug efflux systems called the PACE family, which includes homologs of the AceI transporter from Acinetobacter baumannii. These proteins confer resistance to various biocides and antimicrobial dyes, including chlorhexidine, benzalkonium, proflavine, and acriflavine.
An ace up their sleeve: a transcriptomic approach exposes the AceI efflux protein of Acinetobacter baumannii and reveals the drug efflux potential hidden in many microbial pathogens.
The study identifies AceI as a novel multidrug efflux pump in Acinetobacter baumannii, which provides resistance to chlorhexidine, benzalkonium, acriflavine, and proflavine. AceI is part of the PACE family of multidrug efflux systems, which are conserved in various bacterial species.
Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens.
The study identifies the PACE family of efflux pumps, which confer resistance to various biocides such as chlorhexidine, acriflavine, and proflavine. The AceI protein from Acinetobacter baumannii was shown to mediate resistance when overexpressed in E. coli, and several homologues were found to confer resistance to multiple biocides.
Assembly and regulation of the chlorhexidine-specific efflux pump AceI.
Rescued chlorhexidine activity by resveratrol against carbapenem-resistant Acinetobacter baumannii via down-regulation of AdeB efflux pump.
Resveratrol enhances chlorhexidine susceptibility by down-regulating the AdeB efflux pump in carbapenem-resistant Acinetobacter baumannii.
Biocide-tolerance and antibiotic-resistance in community environments and risk of direct transfers to humans: Unintended consequences of community-wide surface disinfecting during COVID-19?
The paper discusses the mechanisms of biocide tolerance and antibiotic resistance in bacteria, highlighting the role of mutations, horizontal gene transfer, efflux pumps, membrane alterations, and biofilms in developing resistance to disinfectants and antibiotics. It emphasizes the risks posed by the extensive use of disinfectants during the COVID-19 pandemic and the potential for increased antimicrobial resistance.
Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps.
The study characterizes the roles of mlaA, acrB, ompCF, and aceI in chlorhexidine resistance in E. coli through gene deletion mutants and plasmid transformants, demonstrating that these genes contribute to increased MIC values and altered membrane permeability.
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