acnA

aconitate hydratase

Validation StatusCandidate

Overview

Validation Method: transcriptional fusion experiments and RT-qPCR
Drug Classes: Quinolone, Cephalosporin, Fluoroquinolones|Ceftazidime
Organisms: Salmonella enterica serovar Enteritidis, Stenotrophomonas maltophilia
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	3608fs	partially restored antimicrobial susceptibility	Stenotrophomonas maltophilia	Fluoroquinolones\|Ceftazidime	Reslit	Candidate

Papers2

PhoPQ Regulates Quinolone and Cephalosporin Resistance Formation in Salmonella Enteritidis at the Transcriptional Level.

PMID 37184399 · 2023

PhoPQ regulates quinolone and cephalosporin resistance in Salmonella Enteritidis by directly targeting the ompF and acnA genes, affecting envelope integrity, osmotic stress response, and redox balance.

Gene Information

Gene Name: acnA
Allele: acnA
Encodes: aconitate hydratase
Source Database: Reslit
Confers Resistance To: QuinoloneCephalosporin
Organisms Tested In: • Salmonella enterica serovar Enteritidis
Validation Method: transcriptional fusion experiments and RT-qPCR
Sequence Accession: GSE217589

Browse AMR Genes

acnA

Mutations

Gene Information