acnB

Aconitase

Validation StatusCandidate

Overview

Mechanism: Disruption of TCA cycle enzymes leads to decreased gentamicin tolerance
Validation Method: Transposon sequencing (Tn-Seq) and competition assays
Drug Classes: Gentamicin, Sulfamethoxazole
Organisms: Escherichia coli, Comamonas testosteroni
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
L234F	-	-	Comamonas testosteroni	Sulfamethoxazole	Reslit	Candidate

Papers2

Genetic basis of persister tolerance to aminoglycosides in Escherichia coli.

PMID 25852159 · 2015

The study identifies several genes involved in persister tolerance to gentamicin in Escherichia coli, including genes related to the electron transport chain, flagellar formation, and amino acid biosynthesis. Disruption of these genes affects gentamicin tolerance, highlighting their roles in persister formation.

Gene Information

Gene Name: acnB
Allele: acnB
Encodes: Aconitase
Source Database: Reslit
Mechanism: Disruption of TCA cycle enzymes leads to decreased gentamicin tolerance
Confers Resistance To: Gentamicin
Organisms Tested In: • Escherichia coli
Validation Method: Transposon sequencing (Tn-Seq) and competition assays

Browse AMR Genes

acnB

Mutations

Gene Information