Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
drug transporter
Overview
Analysis of a complete library of putative drug transporter genes in Escherichia coli.
The study identified 20 genes in Escherichia coli that confer resistance to various antimicrobial agents, including novel drug resistance determinants such as yceE, yceL, yidY, ydgFE, yegO, cusA, and ybjYZ. Additionally, several previously known genes were found to have broader resistance spectra than previously reported.
Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli.
The study identifies AcrD as an aminoglycoside efflux pump in Escherichia coli, demonstrating its ability to capture and transport aminoglycosides from both the cytoplasm and periplasm.
Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044.
The CpxAR two-component system contributes to resistance against cefepime and chloramphenicol in Klebsiella pneumoniae NTUH-K2044 by modulating efflux pump expression and outer membrane protein profiles.
MexXY multidrug efflux system of Pseudomonas aeruginosa.
The study characterizes the MexXY multidrug efflux system in Pseudomonas aeruginosa, highlighting its role in aminoglycoside resistance. It also identifies related efflux systems in other bacteria such as AcrD in E. coli, AmrAB-OprA in B. pseudomallei, and AdeABC in A. baumannii.
Characterization of AcrD, a resistance-nodulation-cell division-type multidrug efflux pump from the fire blight pathogen Erwinia amylovora.
The study characterizes AcrD, an RND-type multidrug efflux pump in Erwinia amylovora, which confers resistance to several amphiphilic compounds including clotrimazole, luteolin, novobiocin, hygromycin B, cadmium acetate, zinc sulfate, bile salt, deoxycholate, and SDS.
Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells.
The study identifies multiple multi-drug efflux genes, including tolC, acrA, acrB, acrD, acrF, emrA, emrB, macA, and macB, which are significantly upregulated in persister cells, contributing to reduced antibiotic accumulation and increased drug tolerance.
The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.
The study identified 123 distinct antibiotic resistance genes (ARGs) in the genus Serratia, including intrinsic and acquired resistance genes, as well as efflux pump-related genes. Key findings include the detection of various beta-lactamases, aminoglycoside resistance genes, quinolone resistance genes, and efflux pumps. Notably, the study highlights the presence of plasmid-borne ARGs in nosocomial strains and the role of efflux pumps in multidrug resistance.
Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria.
The study shows that colonization of the gut of breastfed infants by B. infantis EVC001 leads to a significant reduction in antibiotic resistance genes (ARGs) compared to controls. The ARGs identified were mainly associated with Escherichia, Clostridium, and Staphylococcus, and conferred resistance to beta-lactams, fluoroquinolones, and multiple drug classes.
Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient
The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.
Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors.
The study identified various antimicrobial resistance genes in Klebsiella isolates from preterm infants, highlighting the presence of multidrug resistance mechanisms.
Clinically relevant mutations in core metabolic genes confer antibiotic resistance.
The study identifies clinically relevant mutations in core metabolic genes that confer antibiotic resistance, demonstrating that metabolic adaptations can play a significant role in antibiotic resistance mechanisms.
Interchangeability of periplasmic adaptor proteins AcrA and AcrE in forming functional efflux pumps with AcrD in Salmonella enterica serovar Typhimurium.
The study shows that AcrE can form a functional complex with AcrD, indicating interchangeability between AcrA and AcrE in forming efflux pumps. Mutations in specific residues of AcrA and AcrE impair AcrD-mediated efflux.
Antibacterial Efficacy of Liposomal Formulations Containing Tobramycin and N-Acetylcysteine against Tobramycin-Resistant Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii.
The study identified various aminoglycoside-modifying enzymes (AMEs) and efflux pump genes contributing to tobramycin resistance in E. coli, K. pneumoniae, and A. baumannii. These genes include acc(3)-IIa, aac(6')-Ib-cr, ant(2")-Ia, aph(6)-Id, aph(3")-Ib, armA, rmtF, acrD, adeA, adeB, adeC, ompA, omp37, csgB, csgD, csgF, csgG, pgaA, pgaB, pgaC, pgaD, csuA, csuB, csuC, csuD, csuE, and bap.
Antibiotic resistance in plant growth promoting bacteria: A comprehensive review and future perspectives to mitigate potential gene invasion risks.
This review highlights the prevalence of antibiotic resistance genes (ARGs) in plant growth-promoting bacteria (PGPB) and emphasizes the potential risks of ARG dissemination through biofertilizers. Key findings include the identification of various ARGs such as bacA, fosB, ermD, bl2a, vanSA, cat, acrD, mexF, mexD, mexW, mexE, mexY, mexX, mexZ, mexR, mexA, mexB, mexC, mexD, mexE, and mexF, which confer resistance to multiple antibiotics.
Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity.
The study characterizes the AcrD efflux pump, highlighting its role in aminoglycoside resistance through structural and functional analyses.
Genomic Characterization and Genetic Profiles of Salmonella Gallinarum Strains Isolated from Layers with Fowl Typhoid in Colombia.
The study identified 26 chromosomal resistance genes in Salmonella Gallinarum strains, primarily encoding efflux pumps, and point mutations in gyrase genes (gyrA and gyrB) associated with quinolone resistance. The gyrB mutation S464T was frequently found in Colombian strains.
Drug resistance and physiological roles of RND multidrug efflux pumps in Salmonella enterica, Escherichia coli and Pseudomonas aeruginosa.
The study characterizes the role of RND multidrug efflux pumps in drug resistance and physiological functions in Salmonella enterica, Escherichia coli, and Pseudomonas aeruginosa. Key findings include the identification of multiple RND efflux pumps and their contributions to multidrug resistance, biofilm formation, and cellular processes.
A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance.
The review discusses various mechanisms of biofilm-induced antimicrobial resistance, including the role of efflux pumps such as AcrAB-TolC, MexAB-OprM, AdeFGH, and AcrD in conferring resistance to multiple classes of antibiotics.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
Genomic Dissection of an Enteroaggregative Escherichia coli Strain Isolated from Bacteremia Reveals Insights into Its Hybrid Pathogenic Potential.
The study identifies multiple efflux pump-encoding genes in the E. coli strain EC092, which contribute to its resistance against several antibiotics including tetracycline, trimethoprim, streptomycin, and sulfamethoxazole.
Antimicrobial and Metal Resistance Genes in Bacteria Isolated from Mine Water in Austria.
The study identified a variety of antimicrobial and metal resistance genes in bacteria isolated from mine water in Austria, highlighting the prevalence of multidrug efflux pumps and beta-lactamase genes. It also noted the presence of specific metal resistance genes such as ruvB, copA, recGM, and mgtA, as well as co-resistance genes like arsBM, acrD, and the mer operon.
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