Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
repressor of the acrAB-TolC efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| K62R | - | - | Escherichia coli, Escherichia spp. | norfloxacinciprofloxacin | Reslit | Candidate |
| V79I | - | - | Escherichia coli | norfloxacinciprofloxacin | Reslit | Candidate |
| C47G | - | - | Escherichia coli | norfloxacinciprofloxacin | Reslit | Candidate |
| T5N | - | disruption of the repressor function, transcriptional regulator AcrR | Escherichia coli, Klebsiella pneumoniae | norfloxacinciprofloxacintigecycline+8 more | Reference Gene CatalogReslit | Confirmed |
| I16F | - | - | Escherichia coli | norfloxacinciprofloxacin | Reslit | Candidate |
| F24L | - | - | Escherichia coli | norfloxacinciprofloxacin | Reslit | Candidate |
| S25P | - | - | Escherichia coli | norfloxacinciprofloxacin | Reslit | Candidate |
| I62F | - | - | Escherichia coli | norfloxacinciprofloxacin | Reslit | Candidate |
| V125I | - | - | Escherichia coli | norfloxacinciprofloxacin | Reslit | Candidate |
| K146T | - | - | Escherichia coli | norfloxacinciprofloxacin | Reslit | Candidate |
| P155L | - | - | Escherichia coli | norfloxacinciprofloxacin | Reslit | Candidate |
| M201R | - | - | Escherichia coli | norfloxacinciprofloxacin | Reslit | Candidate |
| L214F | - | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate |
| E147E | - | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate |
| P155P | - | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate |
| M109I | - | single resistance variant, transcriptional regulator AcrR | Klebsiella pneumoniae | tigecyclinemultiple antibiotics | Card DatabaseReference Gene CatalogReslit | Confirmed |
| W178R | - | - | E. coli | tetracycline | Reslit | Candidate |
| R155* | - | - | Salmonella typhimurium | ciprofloxacin | Reslit | Candidate |
| V29G | - | - | Escherichia coli | fluoroquinoloneslevofloxacinciprofloxacin | Reslit | Supported |
| E81K | - | - | Escherichia coli | gatifloxacin | Reslit | Candidate |
| P161R | - | - | Klebsiella pneumoniae | tetracyclinefluoroquinolonesphenicols+2 more | ResFinder DatabaseReslit | Confirmed |
| F172S | - | - | Klebsiella pneumoniae | tetracyclinefluoroquinolonesphenicols+2 more | ResFinder DatabaseReslit | Confirmed |
| R173G | - | - | Klebsiella pneumoniae | tetracyclinefluoroquinolonesphenicols+2 more | ResFinder DatabaseReslit | Confirmed |
| L195V | - | - | Klebsiella pneumoniae | tetracyclinefluoroquinolonesphenicols+2 more | ResFinder DatabaseReslit | Confirmed |
| F197I | - | - | Klebsiella pneumoniae | tetracyclinefluoroquinolonesphenicols+2 more | ResFinder DatabaseReslit | Confirmed |
| K201M | - | - | Klebsiella pneumoniae | tetracyclinefluoroquinolonesphenicols+2 more | ResFinder DatabaseReslit | Confirmed |
| F204L | - | - | Klebsiella pneumoniae | tigecycline | ResFinder DatabaseReslit | Confirmed |
| G164A | - | - | Klebsiella pneumoniae | fluoroquinolonestigecyclineciprofloxacin | ResFinder DatabaseReslit | Confirmed |
| H115Y | - | - | Escherichia spp., Escherichia coli | ciprofloxacintigecycline | Reslit | Candidate |
| T213I | - | - | Escherichia spp. | ciprofloxacin | Reslit | Candidate |
| N214T | - | Escherichia spp., Escherichia coli | ciprofloxacintigecycline | Reslit | Candidate | |
| G103S | - | - | Escherichia spp. | ciprofloxacin | Reslit | Candidate |
| Y137H | - | - | Escherichia spp. | ciprofloxacin | Reslit | Candidate |
| A53E | - | - | Escherichia spp. | ciprofloxacin | Reslit | Candidate |
| Q183K | - | - | - | phenicolsciprofloxacin | Reslit | Candidate |
| A156S | - | - | - | phenicolsciprofloxacin | Reslit | Candidate |
| M175R | - | - | - | phenicolsciprofloxacin | Reslit | Candidate |
| S25* | - | - | - | phenicolsciprofloxacin | Reslit | Candidate |
| G105D | - | - | Klebsiella pneumoniae | fluoroquinolones | Reslit | Candidate |
| G151D | - | - | Klebsiella pneumoniae | fluoroquinolones | Reslit | Candidate |
| V105M | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| W50R | - | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate |
| Y170* | - | - | - | eravacycline | Reslit | Candidate |
| P82L | - | - | - | eravacycline | Reslit | Candidate |
| T160I | - | - | - | eravacycline | Reslit | Candidate |
| C148R | - | - | - | eravacycline | Reslit | Candidate |
| L187P | - | - | - | eravacycline | Reslit | Candidate |
| T43K | - | - | - | eravacycline | Reslit | Candidate |
| N131Y | - | - | - | eravacycline | Reslit | Candidate |
| Y114F | - | single resistance variant, transcriptional regulator AcrR | Klebsiella pneumoniae | eravacyclinemultiple antibioticstigecycline | Card DatabaseReference Gene CatalogReslit | Confirmed |
| V165I | - | single resistance variant, transcriptional regulator AcrR | Klebsiella pneumoniae | eravacyclinemultiple antibioticstigecycline | Card DatabaseReference Gene CatalogReslit | Confirmed |
| R120P | - | - | - | eravacycline | Reslit | Candidate |
| H186N | - | - | - | eravacycline | Reslit | Candidate |
| T119P | - | - | - | eravacycline | Reslit | Candidate |
| I106F | - | - | - | eravacycline | Reslit | Candidate |
| M109R | - | - | - | eravacycline | Reslit | Candidate |
| R35S | - | - | - | eravacycline | Reslit | Candidate |
| I106L | - | - | - | eravacycline | Reslit | Candidate |
| A159E | - | - | - | eravacycline | Reslit | Candidate |
| A20V | - | - | - | eravacycline | Reslit | Candidate |
| A22P | - | - | - | eravacycline | Reslit | Candidate |
| I141T | - | - | - | eravacycline | Reslit | Candidate |
| P85Q | - | - | E. coli | tetracycline | Reslit | Candidate |
| I45L | - | - | E. coli | tetracycline | Reslit | Candidate |
| 277fs | - | - | Klebsiella pneumoniae | polymyxins | Reslit | Candidate |
| Q78K | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| R13L | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| T18P | - | - | Salmonella enterica | tetracyclinefluoroquinolonesphenicols | Reslit | Candidate |
| G42E | - | - | Salmonella enterica | tetracyclinefluoroquinolonesphenicols | Reslit | Candidate |
| A37V | - | - | Salmonella enterica | tetracyclinefluoroquinolonesphenicols | Reslit | Candidate |
| G25A | - | - | Salmonella enterica | tetracyclinefluoroquinolonesphenicols | Reslit | Candidate |
| I12S | - | - | - | imipenem | Reslit | Candidate |
| S110P | - | - | - | imipenem | Reslit | Candidate |
| A159V | - | - | - | imipenem | Reslit | Candidate |
| R715L | - | - | Klebsiella pneumoniae | ciprofloxacinlevofloxacinmoxifloxacin | Reslit | Candidate |
| M1I | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| K55E | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| W63R | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| F263L | - | - | Escherichia coli | benzalkonium chloridephenicolstriclosan | Reslit | Candidate |
| T12A | - | - | Salmonella enterica | ciprofloxacin | Reslit | Candidate |
| A20T | - | - | Klebsiella pneumoniae | fluoroquinolones | ResFinder Database | Established |
| G121* | - | - | Klebsiella pneumoniae | tigecycline | ResFinder Database | Established |
| G121V | - | - | Klebsiella pneumoniae | tigecycline | ResFinder Database | Established |
| E122K | - | - | Klebsiella pneumoniae | tigecycline | ResFinder Database | Established |
| M123* | - | - | Klebsiella pneumoniae | tigecycline | ResFinder Database | Established |
| A151V | - | - | Klebsiella pneumoniae | fluoroquinolones | ResFinder Database | Established |
| L197L | - | - | Klebsiella pneumoniae | fluoroquinolones | ResFinder Database | Established |
| R45C | - | single resistance variant, transcriptional regulator AcrR | Klebsiella aerogenes, Escherichia coli | multiple antibioticsampicillinphenicols+3 more | Card DatabaseReference Gene Catalog | Confirmed |
| A47fs | - | frameshift mutation | Klebsiella aerogenes | multiple antibiotics | Card Database | Established |
| G28R | - | transcriptional regulator AcrR | Escherichia coli | ampicillinphenicolsfluoroquinolones+2 more | Reference Gene Catalog | Established |
| - | - | Escherichia coli | phenicols | Reslit | Candidate | |
| - | - | - | tigecycline | Reslit | Candidate | |
| K55N | - | Klebsiella pneumoniae | tetracyclinephenicolsfluoroquinolones+1 more | Reslit | Candidate | |
| - | - | - | tigecycline | Reslit | Candidate | |
| - | - | - | fluoroquinolonesciprofloxacinceftazidime+2 more | Reslit | Candidate | |
| - | - | - | tigecycline | Reslit | Candidate | |
| - | - | Escherichia coli | phenicolsfluoroquinolonestetracycline+4 more | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| - | - | - | ciprofloxacinceftazidimecefotaxime+1 more | Reslit | Candidate | |
| - | - | - | ciprofloxacinceftazidimecefotaxime+1 more | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| - | - | - | ciprofloxacinceftazidimecefotaxime+1 more | Reslit | Candidate | |
| - | - | Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa | delafloxacingepotidacinomadacycline | Reslit | Candidate | |
| - | - | Escherichia coli | ampicillin | Reslit | Candidate | |
| - | - | Salmonella enterica | ciprofloxacin | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| A212S | - | Escherichia coli | tigecycline | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | tigecycline | Reslit | Candidate | |
| - | - | - | tigecycline | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| - | - | - | fluoroquinolonesciprofloxacinceftazidime+2 more | Reslit | Candidate | |
| - | - | - | fluoroquinolonesciprofloxacinceftazidime+2 more | Reslit | Candidate | |
| - | - | - | fluoroquinolones | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | norfloxacinciprofloxacin | ResFinder Database | Established | |
| - | - | Klebsiella pneumoniae | norfloxacinciprofloxacin | ResFinder Database | Established |
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
Research Article
Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae.
Research Article
Mutations in acrR were found to lead to AcrAB overexpression, contributing to tigecycline resistance.
Mechanisms of tigecycline resistance among Klebsiella pneumoniae clinical isolates.
Research Article
Klebsiella pneumoniae acrR with mutation conferring multidrug antibiotic resistance; CARD accession: CARD:3003373
acrR
Identification of Evolutionary Trajectories Associated with Antimicrobial Resistance Using Microfluidics.
Research Article
Repression of invasion genes and decreased invasion in a high-level fluoroquinolone-resistant Salmonella typhimurium mutant.
Research Article
Loss-of-function mutation leading to overexpression of AcrAB-TolC efflux pump
Limited Multidrug Resistance Efflux Pump Overexpression among Multidrug-Resistant Escherichia coli Strains of ST131.
Research Article
Mutation in the DNA binding region of AcrR
Interactions of Polymyxin B in Combination with Aztreonam, Minocycline, Meropenem, and Rifampin against Escherichia coli Producing NDM and OXA-48-Group Carbapenemases.
Research Article
associated with increased AcrAB-TolC efflux activity
Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli.
Research Article
Genomic dynamics of high-risk carbapenem-resistant klebsiella pneumoniae clones carrying hypervirulence determinants in Egyptian clinical settings.
Research Article
found in 95% of isolates
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
Research Article
Mutation in acrR leads to tigecycline resistance, but it is not phenotypically expressed.
The Microbiological Characteristics and Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Clinical Samples.
Research Article
Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648.
Research Article
Mutations in acrR contribute to tigecycline nonsusceptibility by overexpression of AcrAB-TolC.
Contribution of target alteration, protection and efflux pump in achieving high ciprofloxacin resistance in Enterobacteriaceae.
Research Article
Mutations in acrR and marR genes were identified in several Escherichia spp. isolates.
Time-Resolved Tracking of Mutations Reveals Diverse Allele Dynamics during Escherichia coli Antimicrobial Adaptive Evolution to Single Drugs and Drug Pairs.
Research Article
Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt.
Research Article
Optimizing Nanopore Sequencing for Rapid Detection of Microbial Species and Antimicrobial Resistance in Patients at Risk of Surgical Site Infections.
Research Article
Detected in Klebsiella pneumoniae
The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli.
Research Article
Mutation in AcrR leads to overexpression of the AcrAB-TolC efflux pump, contributing to ciprofloxacin resistance.
The T5N mutation in AcrR leads to overexpression of the AcrAB-TolC efflux pump, contributing to ciprofloxacin resistance.
'Supermutators' found amongst highly levofloxacin-resistant E. coli isolates: a rapid protocol for the detection of mutation sites.
Research Article
The acrR-V29G mutation was strongly associated with HR isolates.
Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli.
Research Article
Occurrence and mechanisms of tigecycline resistance in carbapenem- and colistin-resistant Klebsiella pneumoniae in Thailand.
Research Article
Klebsiella pneumoniae arms itself: poultry food chain drives spread and evolution of mcr-1.26-IncX4 plasmids.
Research Article
Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae.
Research Article
Effects of a previously selected antibiotic resistance on mutations acquired during development of a second resistance in Escherichia coli.
Research Article
Mutations in acrR were observed in wild-type E. coli adapted to tetracycline.
Genetic Diversity of Polymyxin-Resistance Mechanisms in Clinical Isolates of Carbapenem-Resistant Klebsiella pneumoniae: a Multicenter Study in China.
Research Article
IS kpn26 insertion in acrR was observed in 67 strains
Predicting tigecycline susceptibility in multidrug-resistant Klebsiella species and Escherichia coli strains of environmental origin.
Research Article
Evolution of antimicrobial resistance in E. coli biofilm treated with high doses of ciprofloxacin.
Research Article
Long-term exposure to food-grade disinfectants causes cross-resistance to antibiotics in Salmonella enterica serovar Typhimurium strains with different antibiograms and sequence types.
Research Article
Imipenem heteroresistance but not tolerance in Haemophilus influenzae during chronic lung infection associated with chronic obstructive pulmonary disease.
Research Article
mutations in acrR gene associated with imipenem heteroresistance
Exploring the Genome and Phenotype of Multi-Drug Resistant Klebsiella pneumoniae of Clinical Origin.
Research Article
CRISPR-FRT targets shared sites in a knock-out collection for off-the-shelf genome editing.
Research Article
Associations between sensitivity to antibiotics, disinfectants and heavy metals in natural, clinical and laboratory isolates of Escherichia coli.
Research Article
Development and selection of low-level multi-drug resistance over an extended range of sub-inhibitory ciprofloxacin concentrations in Escherichia coli.
Research Article
The prevalence and mechanism of fluoroquinolone resistance in Escherichia coli isolated from swine farms in China.
Research Article
Mutations in the promoter region
Single-cell genomics reveals population structures from in vitro evolutionary studies of Salmonella.
Research Article
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.
Research Article
Under development. Phenotype should be used with caution.
Tigecycline Susceptibility and Molecular Resistance Mechanisms Among Clinical Klebsiella pneumoniae Strains Isolated During Non-Tigecycline Treatment.
Research Article
Under development. Phenotype should be used with caution.
Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
Research Article
Under development. Phenotype should be used with caution.
The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes.
Research Article
Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance; CARD accession: CARD:3003374
Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates.
Research Article
Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime; CARD accession: CARD:3003807
Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutations.
Research Article
acrR
Identification of AcrAB-TolC Efflux Pump Genes and Detection of Mutation in Efflux Repressor AcrR from Omeprazole Responsive Multidrug-Resistant Escherichia coli Isolates Causing Urinary Tract Infections.
Research Article
acrR
mutation in AcrR repressor leads to efflux pump activation
Metabolic constraints on the evolution of antibiotic resistance.
Research Article
Deletion of acrR led to increased chloramphenicol resistance.
Molecular epidemiology and mechanisms of tigecycline resistance in carbapenem-resistant Klebsiella pneumoniae isolates.
Research Article
Use of whole-genome sequencing to trace, control and characterize the regional expansion of extended-spectrum β-lactamase producing ST15 Klebsiella pneumoniae.
Research Article
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
Research Article
Contributes to tigecycline resistance.
Whole-genome sequencing of Klebsiella pneumoniae MDR circulating in a pediatric hospital setting: a comprehensive genome analysis of isolates from Guayaquil, Ecuador.
Research Article
Mutations in acrR lead to increased efflux pump activity and resistance to fluoroquinolones and beta-lactams.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
Research Article
A 46-week outbreak of ertapenem-resistant, non-carbapenemase encoding Klebsiella pneumoniae ST45 in a paediatric cardiac unit involving shared equipment, United Kingdom, April 2022 to February 2023.
Research Article
Mutations in acrR lead to overexpression of the AcrAB-TolC efflux pump, resulting in fluoroquinolone resistance.
ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro.
Research Article
A shared mechanism of multidrug resistance in laboratory-evolved uropathogenic Escherichia coli.
Research Article
A whole-genome screen identifies Salmonella enterica serovar Typhi genes involved in fluoroquinolone susceptibility.
Research Article
Characterization of Tigecycline Resistance Among Tigecycline Non-susceptible Klebsiella pneumoniae Isolates From Humans, Food-Producing Animals, and in vitro Selection Assay.
Research Article