acrS

efflux pump regulator

Validation StatusSupported

Overview

Mechanism: antibiotic efflux
Validation Method: genomic analysis
Drug Classes: Cefotaxime, Fluoroquinolone, Cephalosporin, Glycylcyclines, Cephalosporins, Penicillin, Tetracycline, Rifamycin, Phenicol, Colistin, Fluoroquinolones
Organisms: Escherichia coli, Klebsiella pneumoniae
Geographic Location: Brazil, South Africa
Papers: 5
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S76R	-	-	Klebsiella pneumoniae	Colistin	Reslit	Candidate
D167N	-	-	Escherichia coli	Fluoroquinolones	Reslit	Candidate

Papers5

Extended Spectrum Beta-Lactamase-Producing Gram-Negative Bacteria Recovered From an Amazonian Lake Near the City of Belém, Brazil.

PMID 30873145 · 2019

The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-2, bla TEM, and bla SHV, in multidrug-resistant gram-negative bacteria from an Amazonian lake. These genes were associated with resistance to cephalosporins and other beta-lactam antibiotics.

Gene Information

Gene Name: acrS
Allele: AcrS
Encodes: efflux pump regulator
Source Database: Reslit
Confers Resistance To: Cefotaxime
Organisms Tested In: • Escherichia coli
Geographic Location: Brazil
Validation Method: genomic analysis
Sequence Accession: PKCA01000000|PYSX01000000

Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient

PMID 31787070 · 2023

The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.

Gene Information

Gene Name: acrS
Allele: AcrS
Encodes: transcriptional regulator
Source Database: Reslit
Organisms Tested In: • Escherichia coli
Validation Method: metagenomic read cloud sequencing and assembly

Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.

PMID 38459466 · 2024

The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.

Gene Information

Gene Name: acrS
Allele: AcrS
Encodes: resistance-nodulation-cell division (RND) antibiotic efflux pump
Source Database: Reslit
Mechanism: antibiotic efflux
Confers Resistance To: FluoroquinoloneCephalosporinGlycylcyclinesCephalosporinsPenicillinTetracyclineRifamycinPhenicol
Organisms Tested In: • Escherichia coli
Geographic Location: South Africa
Validation Method: RGI analysis
Sequence Accession: NCBI:CP083125

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acrS

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