acrab
resistance-nodulation-cell division (RND) family efflux pump
Overview
- Mechanism
- enhanced expression due to insertion of IS186 into acrR
- Validation Method
- agar dilution MIC test
- Drug Classes
- ampicillin, chloramphenicol, florfenicol, cloxacillin, puromycin, erythromycin, methotrexate, novobiocin, ciprofloxacin, norfloxacin, nalidixic acid, rifampin, fusidic acid, streptomycin, sulfacetamide, tetracycline, deoxycholate, sodium cholate, sodium taurodeoxycholate, sodium oxalate, proflavin, crystal violet, acriflavin, ethidium bromide, tetraphenylphosphonium, rhodamine 6g, tetraphenylarsonium chloride, dequalinium chloride, benzalkonium chloride, daunomycin, plumbagin, methyl viologen, fluoroquinolones, tigecycline
- Organisms
- Escherichia coli W3110, Escherichia coli, Proteus mirabilis, Vibrio cholerae
- Papers
- 5
- Databases
- Reslit
Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.
The study identified that the deletion of tolC and acrAB significantly increased susceptibility to various antibiotics, antiseptics, detergents, and dyes in Escherichia coli. Additionally, mdfA and emrE were found to contribute to resistance against specific compounds.
Gene Information
- Gene Name
- acrab
- Allele
- acrAB
- Encodes
- resistance-nodulation-cell division (RND) family efflux pump
- Source Database
- Reslit
- Confers Resistance To
- ampicillinchloramphenicolflorfenicolcloxacillinpuromycinerythromycinmethotrexatenovobiocinciprofloxacinnorfloxacinnalidixic acidrifampinfusidic acidstreptomycinsulfacetamidetetracyclinedeoxycholatesodium cholatesodium taurodeoxycholatesodium oxalateproflavincrystal violetacriflavinethidium bromidetetraphenylphosphoniumrhodamine 6gtetraphenylarsonium chloridedequalinium chloridebenzalkonium chloridedaunomycinplumbaginmethyl viologen
- Organisms Tested In
- • Escherichia coli W3110
- Validation Method
- agar dilution MIC test
Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone.
The study identifies the enhanced expression of multidrug efflux pumps AcrAB and AcrEF in Escherichia coli mutants selected with a fluoroquinolone, associated with insertion element transposition. The mutations in acrR and acrS lead to increased resistance to various antibiotics.
Gene Information
- Gene Name
- acrab
- Allele
- acrAB
- Encodes
- multidrug efflux pump
- Source Database
- Reslit
- Mechanism
- enhanced expression due to insertion of IS186 into acrR
- Confers Resistance To
- fluoroquinolones
- Organisms Tested In
- • Escherichia coli
- Validation Method
- reverse transcriptase PCR and MIC testing
AcrAB Multidrug Efflux Pump Is Associated with Reduced Levels of Susceptibility to Tigecycline (GAR-936) in Proteus mirabilis.
The AcrAB multidrug efflux pump is associated with reduced susceptibility to tigecycline in Proteus mirabilis. Mutations in acrAB led to increased susceptibility to tigecycline, and complementation with the wild-type acrAB gene restored resistance.
Gene Information
- Gene Name
- acrab
- Allele
- acrAB
- Encodes
- multidrug efflux pump
- Source Database
- Reslit
- Mechanism
- efflux pump
- Confers Resistance To
- tigecycline
- Organisms Tested In
- • Proteus mirabilis• Escherichia coli
- Validation Method
- transposon mutagenesis and complementation
- Sequence Accession
- AY061647
Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).
The study identified several efflux transporter genes, including tet(B), tet(C), tet(K), acrAB, acrEF, and bcr, that influence the susceptibility of Escherichia coli to tigecycline. While tigecycline was effective against strains expressing these efflux pumps, it was found to be a substrate for AcrAB and AcrEF, suggesting potential resistance mechanisms.
Gene Information
- Gene Name
- acrab
- Allele
- acrAB
- Encodes
- multidrug efflux transporter
- Source Database
- Reslit
- Mechanism
- efflux pump
- Confers Resistance To
- tigecycline
- Organisms Tested In
- • Escherichia coli
- Validation Method
- ethidium bromide efflux assay
Effect of bile on the cell surface permeability barrier and efflux system of Vibrio cholerae.
Bile induces the expression of the acrAB efflux pump in Vibrio cholerae, which plays a critical role in reducing the entry of hydrophobic compounds into the cells.
Gene Information
- Gene Name
- acrab
- Allele
- acrAB
- Encodes
- RND family efflux pump
- Source Database
- Reslit
- Organisms Tested In
- • Vibrio cholerae
- Validation Method
- RT-PCR analysis of RNA
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