acref
multidrug efflux pump
Overview
- Mechanism
- enhanced expression due to insertion of IS2 into the upstream region of acrEF
- Validation Method
- reverse transcriptase PCR and MIC testing
- Drug Classes
- fluoroquinolones, tetracycline, chloramphenicol, ampicillin, cefuroxime, trimethoprim, erythromycin, clarithromycin, azithromycin, clindamycin, linezolid, oxacillin, tigecycline
- Organisms
- Escherichia coli
- Papers
- 2
- Databases
- Reslit
Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone.
The study identifies the enhanced expression of multidrug efflux pumps AcrAB and AcrEF in Escherichia coli mutants selected with a fluoroquinolone, associated with insertion element transposition. The mutations in acrR and acrS lead to increased resistance to various antibiotics.
Gene Information
- Gene Name
- acref
- Allele
- acrEF
- Encodes
- multidrug efflux pump
- Source Database
- Reslit
- Mechanism
- enhanced expression due to insertion of IS2 into the upstream region of acrEF
- Confers Resistance To
- fluoroquinolonestetracyclinechloramphenicolampicillincefuroximetrimethoprimerythromycinclarithromycinazithromycinclindamycinlinezolidoxacillin
- Organisms Tested In
- • Escherichia coli
- Validation Method
- reverse transcriptase PCR and MIC testing
Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).
The study identified several efflux transporter genes, including tet(B), tet(C), tet(K), acrAB, acrEF, and bcr, that influence the susceptibility of Escherichia coli to tigecycline. While tigecycline was effective against strains expressing these efflux pumps, it was found to be a substrate for AcrAB and AcrEF, suggesting potential resistance mechanisms.
Gene Information
- Gene Name
- acref
- Allele
- acrEF
- Encodes
- multidrug efflux transporter
- Source Database
- Reslit
- Mechanism
- efflux pump
- Confers Resistance To
- tigecycline
- Organisms Tested In
- • Escherichia coli
- Validation Method
- ethidium bromide efflux assay
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