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Explore antimicrobial resistance genes from the literature
Efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| Q335H | - | Neutral | Acinetobacter baumannii | Carbapenem | Reslit | Candidate |
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility.
The BaeSR two-component system regulates the expression of the AdeAB efflux pump genes in Acinetobacter baumannii, thereby influencing tigecycline susceptibility.
The Role of the Two-Component System BaeSR in Disposing Chemicals through Regulating Transporter Systems in Acinetobacter baumannii.
The study identifies that the BaeSR two-component system regulates the expression of efflux pump genes adeA, adeB, adeI, adeJ, adeK, macA, macB, and tolC in Acinetobacter baumannii, contributing to tigecycline resistance. Deletion of baeR reduces the expression of these genes, leading to increased susceptibility to tannic acid and tigecycline.
Acinetobacter baumannii quorum-sensing signalling molecule induces the expression of drug-resistance genes.
The study identifies that the quorum-sensing signaling molecule N-3-OH-C12-HSL induces the expression of drug-resistance genes OXA-51, AmpC, AdeA, and AdeB in Acinetobacter baumannii, enhancing resistance to meropenem.
Genomic insights of Pannonibacter phragmitetus strain 31801 isolated from a patient with a liver abscess.
The study identified a β-lactam resistance gene, NPS β-lactamase, and several multidrug resistance efflux pump genes, including acrB, cmeB, macA, and macB, in Pannonibacter phragmitetus strain 31801, which contributes to its resistance to various antibiotics.
Resistance to pentamidine is mediated by AdeAB, regulated by AdeRS, and influenced by growth conditions in Acinetobacter baumannii ATCC 17978.
The study identifies that the AdeAB efflux pump, regulated by the AdeRS two-component system, mediates resistance to pentamidine, chlorhexidine, and DAPI in Acinetobacter baumannii ATCC 17978. Deletion of adeRS or adeAB reduces resistance to these dicationic compounds, while complementation restores resistance.
Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China.
The study identified 19 drug resistance genes in 10 multidrug-resistant Acinetobacter baumannii strains, with efflux pump genes being the most prevalent. Key genes included aacA4, which had a 19-bp deletion associated with aminoglycoside resistance, and other genes like TEM-1, OXA-23, and ANT(3'')-IIa.
Antibacterial Efficacy of Liposomal Formulations Containing Tobramycin and N-Acetylcysteine against Tobramycin-Resistant Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii.
The study identified various aminoglycoside-modifying enzymes (AMEs) and efflux pump genes contributing to tobramycin resistance in E. coli, K. pneumoniae, and A. baumannii. These genes include acc(3)-IIa, aac(6')-Ib-cr, ant(2")-Ia, aph(6)-Id, aph(3")-Ib, armA, rmtF, acrD, adeA, adeB, adeC, ompA, omp37, csgB, csgD, csgF, csgG, pgaA, pgaB, pgaC, pgaD, csuA, csuB, csuC, csuD, csuE, and bap.
Synergistic Inhibitory Effect of Polymyxin B in Combination with Ceftazidime against Robust Biofilm Formed by Acinetobacter baumannii with Genetic Deficiency in AbaI/AbaR Quorum Sensing.
The study identifies bla OXA-23, IS Aba1, and several efflux pump genes (adeA, adeB, adeC, adeS, adeR) as contributing to carbapenem and multidrug resistance in Acinetobacter baumannii. Additionally, the AbaI/AbaR quorum sensing system is implicated in regulating biofilm formation and motility.
Resistance mechanisms of tigecycline in Acinetobacter baumannii.
The study identifies several efflux pumps, outer membrane permeability alterations, and antibiotic target modifications as key mechanisms of tigecycline resistance in Acinetobacter baumannii.
The Mechanism of Tigecycline Resistance in Acinetobacter baumannii under Sub-Minimal Inhibitory Concentrations of Tigecycline.
The study identified the RND efflux pump AdeABC as a key factor in tigecycline resistance in Acinetobacter baumannii under sub-MIC conditions. High expression of adeA and adeB was associated with rapid tigecycline resistance acquisition.
The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates.
The study identified multiple biocide resistance genes in Brazilian ESKAPE isolates, highlighting the presence of resistance mechanisms against benzalkonium chloride, chlorhexidine, and triclosan. Key genes included efflux pumps (acrE/envC, acrF/envD, adeA, adeB, adeC, mexD, oqxA, oqxB, qacA, qacR, sdeB), enzyme modifiers (fabV, sh-fabI), and porins (kpnO).
Contribution of RND superfamily multidrug efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence factors in multidrug-resistant Acinetobacter baumannii AYE.
The study identifies the contributions of RND efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence in multidrug-resistant Acinetobacter baumannii AYE. Disruption of these pumps reduces resistance to multiple antimicrobial classes and affects biofilm formation and virulence.
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