Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump component
Overview
Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii.
The study identifies multiple efflux pumps, porins, and β-lactamases contributing to multidrug resistance in Acinetobacter baumannii, including adeB, adeJ, tetB, tetA(39), and aacC1, aphA1, aadB genes, along with mutations in gyrA and parC.
Genomic insights of Pannonibacter phragmitetus strain 31801 isolated from a patient with a liver abscess.
The study identified a β-lactam resistance gene, NPS β-lactamase, and several multidrug resistance efflux pump genes, including acrB, cmeB, macA, and macB, in Pannonibacter phragmitetus strain 31801, which contributes to its resistance to various antibiotics.
Overproduction of efflux pumps caused reduced susceptibility to carbapenem under consecutive imipenem-selected stress in Acinetobacter baumannii.
The study shows that overproduction of efflux pumps, particularly the RND family members adeB, adeG, and adeJ, leads to reduced susceptibility to carbapenems in Acinetobacter baumannii under consecutive imipenem-selected stress. A single nucleotide mutation in the adeR gene of the adeRS regulatory system was identified as a potential cause of this overproduction.
Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm.
The study identified 50 unique antibiotic resistance genes (ARGs) in food waste, compost, and farm products, with a focus on aminoglycoside, tetracycline, and macrolide resistance. Key ARGs included aph(6)-1d, lmrD, mefA, mel, abeM, abeS, adeF, adeG, adeI, adeJ, adeK, emrD, sul2, tetH, tetM, tetO, tetW, and tetX, which were found in various samples and showed resistance to multiple drug classes.
Overexpression of Efflux Pumps, Mutations in the Pumps' Regulators, Chromosomal Mutations, and AAC(6′)-Ib-cr Are Associated With Fluoroquinolone Resistance in Diverse Sequence Types of Neonatal Septicaemic Acinetobacter baumannii: A 7-Year Single Center Study.
The study identifies aac(6')-Ib-cr as a significant contributor to fluoroquinolone resistance in Acinetobacter baumannii, alongside chromosomal mutations in gyrA and parC, and overexpression of efflux pumps regulated by adeR and adeS.
Efflux Pump Overexpression Profiling in Acinetobacter baumannii and Study of New 1-(1-Naphthylmethyl)-Piperazine Analogs as Potential Efflux Inhibitors.
The study identifies the overexpression of efflux pump genes such as adeJ, adeG, adeB, abeM, abaQ, and craA in Acinetobacter baumannii strains, contributing to fluoroquinolone resistance. It also evaluates new 1-(1-naphthylmethyl)-piperazine analogs as potential efflux pump inhibitors.
Hospital sink traps as a potential source of the emerging multidrug-resistant pathogen Cupriavidus pauculus: characterization and draft genome sequence of strain MF1.
The study identifies 12 antibiotic resistance genes in the draft genome of Cupriavidus pauculus strain MF1, including genes encoding β-lactamases, efflux pumps, and a colistin resistance determinant. The isolate shows resistance to meropenem, amoxicillin, amikacin, gentamicin, and colistin, but susceptibility to cefotaxime, cefepime, imipenem, and ciprofloxacin.
Resistance mechanisms of tigecycline in Acinetobacter baumannii.
The study identifies several efflux pumps, outer membrane permeability alterations, and antibiotic target modifications as key mechanisms of tigecycline resistance in Acinetobacter baumannii.
C7-Substituted Quinolines as Potent Inhibitors of AdeG Efflux Pumps in Acinetobacter baumannii.
The study identifies C7-substituted quinolines as potent inhibitors of the AdeG efflux pump in Acinetobacter baumannii, enhancing the efficacy of chloramphenicol.
Comprehensive molecular epidemiology of Acinetobacter baumannii from diverse sources in Nigeria.
The study identified 168 AMR genes in 189 Nigerian A. baumannii isolates, including blaADC-79, blaOXA-23, aph(3")-Ib, and others, highlighting the widespread presence of multidrug resistance.
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