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Explore antimicrobial resistance genes from the literature
RND efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S437T | - | - | Acinetobacter baumannii | Tetracycline | Reslit | Candidate |
Single-step selection of drug resistant Acinetobacter baylyi ADP1 mutants reveals a functional redundancy in the recruitment of multidrug efflux systems.
The study identifies the RND efflux pump adeJ and the MFS efflux pump craA as key contributors to multidrug resistance in Acinetobacter baylyi ADP1. A T to G substitution upstream of the craA translation initiation codon was found to enhance mRNA stability and contribute to resistance.
Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii.
The study identifies multiple efflux pumps, porins, and β-lactamases contributing to multidrug resistance in Acinetobacter baumannii, including adeB, adeJ, tetB, tetA(39), and aacC1, aphA1, aadB genes, along with mutations in gyrA and parC.
Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance.
The study identified that the upregulation of adeB, adeJ, and macB genes is responsible for tigecycline resistance, while increased abeS expression is strongly related to amikacin resistance in multidrug-resistant Acinetobacter baumannii isolates.
The Role of the Two-Component System BaeSR in Disposing Chemicals through Regulating Transporter Systems in Acinetobacter baumannii.
The study identifies that the BaeSR two-component system regulates the expression of efflux pump genes adeA, adeB, adeI, adeJ, adeK, macA, macB, and tolC in Acinetobacter baumannii, contributing to tigecycline resistance. Deletion of baeR reduces the expression of these genes, leading to increased susceptibility to tannic acid and tigecycline.
Genomic insights of Pannonibacter phragmitetus strain 31801 isolated from a patient with a liver abscess.
The study identified a β-lactam resistance gene, NPS β-lactamase, and several multidrug resistance efflux pump genes, including acrB, cmeB, macA, and macB, in Pannonibacter phragmitetus strain 31801, which contributes to its resistance to various antibiotics.
Metagenomics Reveals the Impact of Wastewater Treatment Plants on the Dispersal of Microorganisms and Genes in Aquatic Sediments.
The study identifies several antibiotic resistance genes (ARGs) in wastewater treatment plant (WWTP) effluents and lake sediments, highlighting the influence of WWTPs on the dispersal of these genes in aquatic environments. Key ARGs include strA, acrB, adeJ, mexB, and smeE, which are associated with aminoglycoside and multidrug resistance.
Overproduction of efflux pumps caused reduced susceptibility to carbapenem under consecutive imipenem-selected stress in Acinetobacter baumannii.
The study shows that overproduction of efflux pumps, particularly the RND family members adeB, adeG, and adeJ, leads to reduced susceptibility to carbapenems in Acinetobacter baumannii under consecutive imipenem-selected stress. A single nucleotide mutation in the adeR gene of the adeRS regulatory system was identified as a potential cause of this overproduction.
Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China.
The study identified 19 drug resistance genes in 10 multidrug-resistant Acinetobacter baumannii strains, with efflux pump genes being the most prevalent. Key genes included aacA4, which had a 19-bp deletion associated with aminoglycoside resistance, and other genes like TEM-1, OXA-23, and ANT(3'')-IIa.
Characterization of an Environmental Multidrug-Resistant Acinetobacter seifertii and Comparative Genomic Analysis Reveals Co-occurrence of Antimicrobial Resistance and Metal Tolerance Determinants.
The study characterizes an environmental multidrug-resistant Acinetobacter seifertii isolate (SAb133) and identifies multiple antimicrobial resistance genes, metal tolerance genes, and virulence factors. Key findings include the presence of bla ADC–25, bla TEM, and various efflux pump genes, along with metal tolerance genes and virulence factors.
An NDM-1-Producing Acinetobacter towneri Isolate from Hospital Sewage in China.
Synergistic Antibacterial Activity of Combined Antimicrobials and the Clinical Outcome of Patients With Carbapenemase-Producing Acinetobacter baumannii Infection.
The study identified bla OXA--23 as the primary carbapenemase gene in CRAB strains, and overexpression of efflux pump genes adeB, adeJ, and abeM contributed to resistance. Polymyxin plus sulbactam showed the highest synergistic effect against CRAB.
Overexpression of Efflux Pumps, Mutations in the Pumps' Regulators, Chromosomal Mutations, and AAC(6′)-Ib-cr Are Associated With Fluoroquinolone Resistance in Diverse Sequence Types of Neonatal Septicaemic Acinetobacter baumannii: A 7-Year Single Center Study.
The study identifies aac(6')-Ib-cr as a significant contributor to fluoroquinolone resistance in Acinetobacter baumannii, alongside chromosomal mutations in gyrA and parC, and overexpression of efflux pumps regulated by adeR and adeS.
Efflux Pump Overexpression Profiling in Acinetobacter baumannii and Study of New 1-(1-Naphthylmethyl)-Piperazine Analogs as Potential Efflux Inhibitors.
The study identifies the overexpression of efflux pump genes such as adeJ, adeG, adeB, abeM, abaQ, and craA in Acinetobacter baumannii strains, contributing to fluoroquinolone resistance. It also evaluates new 1-(1-naphthylmethyl)-piperazine analogs as potential efflux pump inhibitors.
The roles of history, chance, and natural selection in the evolution of antibiotic resistance.
The study identifies mutations in adeJ and ftsI as key drivers of resistance to ceftazidime and imipenem, respectively, in Acinetobacter baumannii, highlighting the role of genetic reversion in modulating resistance trade-offs.
Whole-genome sequencing for the characterization of resistance mechanisms and epidemiology of colistin-resistant Acinetobacter baumannii.
The study identified several beta-lactam resistance genes, including ADC-18, OXA-133, OXA-23, OXA-66, TEM-1, VIM-2, and RND efflux pumps (adeI, adeJ, adeK, adeN) in colistin-resistant Acinetobacter baumannii strains.
Resistance mechanisms of tigecycline in Acinetobacter baumannii.
The study identifies several efflux pumps, outer membrane permeability alterations, and antibiotic target modifications as key mechanisms of tigecycline resistance in Acinetobacter baumannii.
Characterization of pyridylpiperazine-based efflux pump inhibitors for Acinetobacter baumannii.
The study identifies AdeJ as a target of pyridylpiperazine (PyrPip) efflux pump inhibitors (EPIs) in Acinetobacter baumannii, demonstrating that these EPIs can inhibit the activity of AdeJ and enhance antibiotic susceptibility.
Regulation of overexpressed efflux pump encoding genes by cinnamon oil and trimethoprim to abolish carbapenem-resistant Acinetobacter baumannii clinical strains.
The study identifies the efflux pump genes adeB, adeC, adeJ, and adeK as contributing to carbapenem resistance in Acinetobacter baumannii. The use of cinnamon oil and trimethoprim was shown to downregulate these genes, thereby reducing resistance.
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