Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S437T | - | - | Acinetobacter baumannii | Tetracycline | Reslit | Candidate |
The Role of the Two-Component System BaeSR in Disposing Chemicals through Regulating Transporter Systems in Acinetobacter baumannii.
The study identifies that the BaeSR two-component system regulates the expression of efflux pump genes adeA, adeB, adeI, adeJ, adeK, macA, macB, and tolC in Acinetobacter baumannii, contributing to tigecycline resistance. Deletion of baeR reduces the expression of these genes, leading to increased susceptibility to tannic acid and tigecycline.
Extended Spectrum Beta-Lactamase-Producing Gram-Negative Bacteria Recovered From an Amazonian Lake Near the City of Belém, Brazil.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-2, bla TEM, and bla SHV, in multidrug-resistant gram-negative bacteria from an Amazonian lake. These genes were associated with resistance to cephalosporins and other beta-lactam antibiotics.
Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China.
The study identified 19 drug resistance genes in 10 multidrug-resistant Acinetobacter baumannii strains, with efflux pump genes being the most prevalent. Key genes included aacA4, which had a 19-bp deletion associated with aminoglycoside resistance, and other genes like TEM-1, OXA-23, and ANT(3'')-IIa.
Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm.
The study identified 50 unique antibiotic resistance genes (ARGs) in food waste, compost, and farm products, with a focus on aminoglycoside, tetracycline, and macrolide resistance. Key ARGs included aph(6)-1d, lmrD, mefA, mel, abeM, abeS, adeF, adeG, adeI, adeJ, adeK, emrD, sul2, tetH, tetM, tetO, tetW, and tetX, which were found in various samples and showed resistance to multiple drug classes.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Whole-genome sequencing for the characterization of resistance mechanisms and epidemiology of colistin-resistant Acinetobacter baumannii.
The study identified several beta-lactam resistance genes, including ADC-18, OXA-133, OXA-23, OXA-66, TEM-1, VIM-2, and RND efflux pumps (adeI, adeJ, adeK, adeN) in colistin-resistant Acinetobacter baumannii strains.
Resistance mechanisms of tigecycline in Acinetobacter baumannii.
The study identifies several efflux pumps, outer membrane permeability alterations, and antibiotic target modifications as key mechanisms of tigecycline resistance in Acinetobacter baumannii.
Regulation of overexpressed efflux pump encoding genes by cinnamon oil and trimethoprim to abolish carbapenem-resistant Acinetobacter baumannii clinical strains.
The study identifies the efflux pump genes adeB, adeC, adeJ, and adeK as contributing to carbapenem resistance in Acinetobacter baumannii. The use of cinnamon oil and trimethoprim was shown to downregulate these genes, thereby reducing resistance.
Antimicrobial resistance and virulence factors analysis of a multidrug-resistant Acinetobacter baumannii isolated from chickens using whole-genome sequencing.
The study identified 41 antimicrobial resistance genes in the multidrug-resistant Acinetobacter baumannii Y03 isolate, including genes conferring resistance to beta-lactams, phenicols, macrolides, lincosamides, aminoglycosides, and nitrofurans.
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