Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
negative regulator of efflux pumps
Overview
Reslit |
| Candidate |
Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle.
The study shows that bacterial lifestyle (planktonic vs. biofilm) influences the genetic mechanisms of antibiotic resistance. Planktonic populations developed resistance through mutations in DNA gyrase (gyrA) and topoisomerase IV (parC), while biofilm populations relied on mutations in efflux pump regulators (adeL and adeN).
Comparative genomic analysis and multi-drug resistance differences of Acinetobacter baumannii in Chongqing, China.
The study identified 19 drug resistance genes in 10 multidrug-resistant Acinetobacter baumannii strains, with efflux pump genes being the most prevalent. Key genes included aacA4, which had a 19-bp deletion associated with aminoglycoside resistance, and other genes like TEM-1, OXA-23, and ANT(3'')-IIa.
Molecular characterisation of Acinetobacter baumannii isolates from bloodstream infections in a tertiary-level hospital in South Africa.
The study identified colistin-resistant Acinetobacter baumannii isolates with resistance genes including bla OXA-23, bla NDM-1, lps B, and various efflux pumps. These isolates exhibited extensive drug resistance (XDR) and were associated with sequence types ST1 and ST2.
Fitness Costs of Tigecycline Resistance in Acinetobacter baumannii and the Resistance Mechanism Revealed by a Transposon Mutation Library.
The study identifies adeL as a gene whose disruption leads to tigecycline resistance in Acinetobacter baumannii. The resistance mechanism involves the regulation of the RND-type efflux system by AdeL.
Identification of determinants that allow maintenance of high-level fluoroquinolone resistance in Acinetobacter baumannii.
The study identifies genes and mutations that contribute to the fitness of fluoroquinolone-resistant (FQR) strains overexpressing RND efflux pumps in Acinetobacter baumannii. Key findings include the role of adeAB, adeFGH, and adeIJK efflux pumps in maintaining high-level fluoroquinolone resistance, along with mutations in regulatory genes adeS, adeL, and adeN that affect pump expression.
Comprehensive molecular epidemiology of Acinetobacter baumannii from diverse sources in Nigeria.
The study identified 168 AMR genes in 189 Nigerian A. baumannii isolates, including blaADC-79, blaOXA-23, aph(3")-Ib, and others, highlighting the widespread presence of multidrug resistance.
No comments yet. Be the first to comment!
© 2026 ResLit. Data sourced from PubMed literature analysis.
Built for antimicrobial resistance research